Results 131 to 140 of about 250,818 (300)

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Development of adenosine signalling in the cerebellum [PDF]

The release and clearance of adenosine are reasonably well-documented in the mature CNS but relatively little is known about how adenosine signalling changes during postnatal development.
Atterbury, Alison
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Cardioplegia with Adenosine and Adenosine Triphosphate in the Isolated Guinea Pig Heart.

, 1992
In order to determine the effect of adenosine triphosphate (ATP) and adenosine in cardioplegic solutions, a comparative study has been undertaken in isolated guinea pig hearts using the Langendorf perfusion technique as a model of cardiopulmonary ...
Halim SONCUL, ERSOZ, A, Levent GÖKGÖZ, SINCI, V, Melih ALTAN, Ali ERSÖZ, SONCUL, H, Kamil AYRANCIOGLU, ALTAN, M, AYRANCIOGLU, K, KARASU, ÇİMEN, Volkan SINCI, Cimen KARASU, GOKGOZ, L   +13 more
core   +1 more source

Engineering‐Modulated Molybdenum Enzymes Strategy for Tumor‐Specific Metabolic‐Immunotherapy

Advanced Science, EarlyView.
Biodegradable molybdenum sulfide nanoparticles were synthesized via a one‐pot strategy to increase molybdenum enzyme activity and thus effectively potentiate anti‐tumor immunity by integrating molybdenum‐based metalloimmunotherapy with hydrogen sulfide gas therapy.
Xiaoxiao Pan, Zifan Pei, Jie Wu, Nan Jiang, Qian Li, Yuqi Yang, Jie Cao, Yechen Huang, Shumin Sun, Qialu Du, Zhicheng Liu, Lin Zhang, Fei Gong, Jinhua Zhou, Liang Cheng   +14 more
wiley   +1 more source

Relationship between Oxidative Stress and Cellular Adenosine Triphosphate Levels

Recent Trends in Pharmacology
Oxidative stress (OS) refers to the deterioration of the balance between oxidants and antioxidants in favor of oxidants, and this may lead to disruptions in redox signaling and control and/or damage at the molecular level.
Seval Bulut, Halis Süleyman
doaj   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Structural and enzymatic characterisation of nucleoside triphosphate diphosphohydrolases from Trifolium repens and Dolichos biflorus [PDF]

, 2012
Extracellular nucleoside triphosphate diphosphohydrolases (NTPDases) are enzymes that reduce the extracellular nucleotide signal and inactivate the purinogenic signalling pathway.
Cumming, Mathew Hoani
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Adenosine triphosphate: established and potential clinical applications.

, 1999
Department of Internal Medicine II, Erasmus University Rotterdam, The Netherlands. Adenosine 5'-triphosphate (ATP) is a purine nucleotide found in every cell of the human body.
Agteresch, H.J., Wilson, J.H.P., van den Berg, J.W.O., Dagnelie, P.C.   +3 more
core   +1 more source

Interference of ATP‐Binding Cassette Transporter by Functional Nano‐Delivery System for High Efficiency Management of Insecticide‐Resistant Nilaparvata lugens

Advanced Science, EarlyView.
A ZIF‐90 nanocarrier delivers dinotefuran and suppresses NlABCG3 and NlABCH1 in resistant Nilaparvata lugens. This system combines pH/ATP‐triggered release with enhanced foliar retention, improving efficacy while sparing honeybees and promoting rice growth, offering a promising resistance‐breaking strategy.
Chengshuai He, Hejun Ren, Shuo Zhang, Jikang Cheng, Hui Zhang, Jiao Liu, Sijie Wang, Congfen Gao, Yanchao Zhang, Yunhao Gao   +9 more
wiley   +1 more source

The magnesium ion-dependent adenosine triphosphatase of myosin:two-step processes of adenosine triphosphate association and adenosine diphosphate dissociation

, 1974
The magnesium ion-dependent adenosine triphosphatase of myosin:two-step processes of adenosine triphosphate association and adenosine diphosphate ...
David R. Trentham (2992026), Herbert Gutfreund (7580309), Clive R. Bagshaw (1271121), Roger S. Goody (37534), John F. Eccleston (1268865), Fritz Eckstein (7580306)   +5 more
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