Results 51 to 60 of about 353,372 (343)

Adenosine Triphosphate in Mammalian Spermatozoa [PDF]

Nature, 1946
THE presence of adenosine triphosphoric acid (that is, of readily hydrolysable phosphorus) in mammalian spermatozoa has been established by Ivanov and Kanygina1 and by Lardy, Hansen and Phillips2.
I I, IVANOV, B S, KASSAVINA, L D, FOMENKO   +2 more
openaire   +2 more sources

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

Extracellular nucleotides mediate viral central nervous system infections: Key alarmins of neuroinflammation and neurodegeneration

Neural Regeneration Research
Recent increases in infectious diseases affecting the central nervous system have raised concerns about their role in neuroinflammation and neurodegeneration.
Raíssa Leite-Aguiar, Elaine Paiva-Pereira, Robson Coutinho-Silva, Cláudia Pinto Figueiredo, Luiz Eduardo Baggio Savio   +4 more
doaj   +1 more source

Microcystin-LR acute exposure does not alter in vitro and in vivo ATP, ADP and AMP hydrolysis in adult zebrafish (Danio rerio) brain membranes

Journal of Xenobiotics, 2012
Microcystins (MCs) are toxins produced by cyanobacteria during the blooms that could accumulate in aquatic animals and be relocated to higher trophic levels.
Luiza Wilges Kist, Rachel Seemann Fritsch, João Sarkis Yunes, Carla Denise Bonan, Maurício Reis Bogo   +4 more
doaj   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Baicalin inhibited PANX-1/P2Y6 signaling pathway activation in porcine aortic vascular endothelial cells infected by Glaesserella parasuis

Heliyon
Glaesserella parasuis can induce endothelial barrier damage in piglets, although the mechanism by which this pathogen triggers inflammatory damage remains unclear. Baicalin possesses anti-inflammatory and anti-oxidant activities.
Shulin Fu, Xinyue Tian, Chun Peng, Dan Zhang, Linglu Zhou, Yuzhen Yuan, Jing He, Ling Guo, Yinsheng Qiu, Chun Ye, Yu Liu, Bingbing Zong   +11 more
doaj   +1 more source

Vasodepressor Effects of Adenosine in the Cat are Independent of Cyclooxygenase, Potassium Channels, and Nitric Oxide Pathways

Drugs in R&D, 2019
Background Pulmonary arterial hypertension is a hemodynamic disorder. Signs and symptoms are generally difficult to recognize because they are non-specific. The current treatment for pulmonary arterial hypertension offers no cure or prevention; therefore,
Alan David Kaye, Syed R. Baber, Mohammed T. Sharief, Rachel J. Kaye, Elyse M. Cornett   +4 more
doaj   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Adenosine-Sensitive Focal Reentrant Atrial Tachycardia Originating From the Mitral Annulus-Aorta Junction

Journal of Arrhythmia, 2008
Adenosine-sensitive reentrant atrial tachycardia (AT) has been recognized to originate from the confined area of either the right or left atiroventricular nodal regions.
Itsuro Morishima, MD, Takahito Sone, MD, Hideyuki Tsuboi, MD, Hiroaki Mukawa, MD, Michitaka Uesugi, MD   +4 more
doaj   +1 more source

LDL-cholesterol reduction in patients with hypercholesterolemia by modulation of adenosine triphosphate-citrate lyase and adenosine monophosphate-activated protein kinase

Current Opinion in Lipidology, 2014
Purpose of review To review the profile of ETC-1002, as shown in preclinical and clinical studies, including LDL-cholesterol (LDL-C)-lowering activity and beneficial effects on other cardiometabolic risk markers as they relate to the inhibition of ...
S. Filippov, Stephen L. Pinkosky, R. Newton   +2 more
semanticscholar   +1 more source