Results 151 to 160 of about 2,006 (160)

Studies on the Chemical Synthesis of Potential Antimetabolites. 35.¹Synthesis of 2-Chloro-1-deazaadenosine and 2-Chloro-1-deazainosine as Candidate Inhibitors forS-Adenosylhomocysteinases and Methyltransferases

Nucleosides and Nucleotides, 1983
Abstract The syntheses of 2-chloro-1-deazaadenosine (2) and 2-chloro-1-deazainosine (3) are described. Conversion of 7-ribosylated 6-chloro-1-deazapurine 3-oxide to the desired 2,6-disubstituted 9-ribosyl-1-deazapurines was effected by a series of reactions involving “deoxygenative chlorination” and transglycosylation in satisfactory yields.
Tokuo Itoh, Tomokazu Sugawara, Akihiko Nomura, Yoshihisa Mizuno   +3 more
openaire   +1 more source

Baicalein specifically suppresses microsatellite instability colorectal cancer by targeting adenosylhomocysteinase to inhibit histone H3 lysine 4 trimethylation-mediated cancer stemness

Phytomedicine
Patients with microsatellite instability (MSI) colorectal cancer (CRC) face significant challenges due to chemotherapy resistance and limited immunotherapy response, underscoring the urgent need for MSI-specific therapies. Baicalein, a trihydroxyflavone compound derived from Scutellaria baicalensis, has demonstrated tumor-suppressive potential. However,
Yaqiu, Zheng, Yu, Li, Minling, Lu, Zhen, Jia, Ting, Wan, Zizheng, Li, Yukai, Huang, Chishun, Zhou, Huiyan, Zeng, Xin, Jin, Zhongqiu, Liu, Linlin, Lu   +11 more
openaire   +2 more sources

Interaction of 9-beta-D-arabinofuranosyladenine, 9-beta-D-arabinofuranosyladenine 5'-monophosphate, and 9-beta-D-arabinofuranosyladenine 5'-triphosphate with S-adenosylhomocysteinase.

Cancer research, 1981
9-beta-D-Arabinofuranosyladenine (ara-A), 9-beta-D-arabinofuranosyladenine 5'-monophosphate, and 9-beta-D-arabinofuranosyladenine 5'-triphosphate competitively inhibit both the synthesis and hydrolysis of S-adenosylhomocysteine catalyzed by S-adenosylhomocysteinase [S-adenosylhomocysteine hydrolase (EC 3.3.1.1)] from mouse liver, and the inhibitor ...
S, Helland, P M, Ueland
openaire   +1 more source

Evidence for an essential histidine residue in S-adenosylhomocysteinase from rat liver

Biochemistry, 1983
Tomoharu Gomi, T Gomi, Motoji Fujioka
exaly  

Adenosylhomocysteinase–adenosine complex links m6A and cancer lipid metabolism

Trends in Biochemical Sciences
Hang Qin, Yajie Qi, Yanqiang Li
openaire   +1 more source

The mechanism of inactivation of S-adenosylhomocysteinase by 2′-deoxyadenosine

Biochemical and Biophysical Research Communications, 1980
R H Abeles, A H Tashjian, A H Tashjian
exaly  

S-adenosylhomocysteinase from mouse liver. Inactivation of the enzyme in the presence of metabolites

International Journal of Biochemistry & Cell Biology, 1982
Per Magne Ueland
exaly  

[Biological methylations and S-adenosylhomocysteinase].

Seikagaku. The Journal of Japanese Biochemical Society, 1985
openaire   +1 more source

Chemical modification of S-adenosylhomocysteinase by a water-soluble carbodiimide

Archives of Biochemistry and Biophysics, 1985
Yoshimi Takata, Tomoharu Gomi, Motoji Fujioka   +2 more
exaly  

Adenosylhomocysteinase from Yellow Lupin Seeds. Purification and Properties

FEBS Journal, 1977
A Guranowski
exaly