Results 161 to 170 of about 3,470 (173)
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Biochemistry, 1986
Homogeneous S-adenosylhomocysteinase (AdoHcyase) from rat liver is a tetrameric enzyme that contains four molecules of tightly bound NAD per mole of enzyme. We report here that incubation of the rat liver enzyme with ATP, Mg2+, and KCl leads to conversion of the active enzyme to an inactive form with release of all enzyme-bound NAD which can be ...
G, de la Haba +5 more
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Homogeneous S-adenosylhomocysteinase (AdoHcyase) from rat liver is a tetrameric enzyme that contains four molecules of tightly bound NAD per mole of enzyme. We report here that incubation of the rat liver enzyme with ATP, Mg2+, and KCl leads to conversion of the active enzyme to an inactive form with release of all enzyme-bound NAD which can be ...
G, de la Haba +5 more
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Planta, 1978
The activities of adenosylhomocysteinase (EC 3.3.1.1) and adenosine nucleosidase (EC 3.2.2.7) were assayed in extracts from yellow lupin (Lupinus luteus L.) cotyledons at different stages of seed formation and seedling development. Adenosylhomocysteinase activity was demonstrated in all the cotyledon extracts examined. Its lowest level was found in the
A, Guranowski, J, Pawełkiewicz
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The activities of adenosylhomocysteinase (EC 3.3.1.1) and adenosine nucleosidase (EC 3.2.2.7) were assayed in extracts from yellow lupin (Lupinus luteus L.) cotyledons at different stages of seed formation and seedling development. Adenosylhomocysteinase activity was demonstrated in all the cotyledon extracts examined. Its lowest level was found in the
A, Guranowski, J, Pawełkiewicz
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Biochimica et Biophysica Acta (BBA) - General Subjects, 1979
Abstract A fraction of adenosine bound to the cyclic AMP-adenosine binding protein/ S-adenosylhomocysteinase from mouse liver is almost instantaneously converted to adenine. The conversion ratio, defined ad the concentration of adenine divided by the sum of the concentrations of adenine and adenosine, and the sequestration of adenosine, determined as
J, Saebø, P M, Ueland
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Abstract A fraction of adenosine bound to the cyclic AMP-adenosine binding protein/ S-adenosylhomocysteinase from mouse liver is almost instantaneously converted to adenine. The conversion ratio, defined ad the concentration of adenine divided by the sum of the concentrations of adenine and adenosine, and the sequestration of adenosine, determined as
J, Saebø, P M, Ueland
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Nucleosides and Nucleotides, 1982
Abstract 9-β-D-Arabinofuranosyldeazaadenines [1-deaza-araA (4a) and 3-deaza-araA (4b)] were prepared from 6-chloro-β-D-ribofuranosyl-1- (6a) and -3-deazapurine (6b), respectively. Synthesis of 2′-deoxy-1-deaza-adenosine (5a) from 1-deazaadenosine (6c) is also described.
Tomokazu Sugawara +3 more
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Abstract 9-β-D-Arabinofuranosyldeazaadenines [1-deaza-araA (4a) and 3-deaza-araA (4b)] were prepared from 6-chloro-β-D-ribofuranosyl-1- (6a) and -3-deazapurine (6b), respectively. Synthesis of 2′-deoxy-1-deaza-adenosine (5a) from 1-deazaadenosine (6c) is also described.
Tomokazu Sugawara +3 more
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Nucleosides and Nucleotides, 1983
Abstract The syntheses of 2-chloro-1-deazaadenosine (2) and 2-chloro-1-deazainosine (3) are described. Conversion of 7-ribosylated 6-chloro-1-deazapurine 3-oxide to the desired 2,6-disubstituted 9-ribosyl-1-deazapurines was effected by a series of reactions involving “deoxygenative chlorination” and transglycosylation in satisfactory yields.
Tokuo Itoh +3 more
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Abstract The syntheses of 2-chloro-1-deazaadenosine (2) and 2-chloro-1-deazainosine (3) are described. Conversion of 7-ribosylated 6-chloro-1-deazapurine 3-oxide to the desired 2,6-disubstituted 9-ribosyl-1-deazapurines was effected by a series of reactions involving “deoxygenative chlorination” and transglycosylation in satisfactory yields.
Tokuo Itoh +3 more
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1986
S-Adenosylhomocysteine (AdoHcy), first isolated as one of the products of transmethylation reactions from S-adenosylmethionine (AdoMet) (Cantoni & Scarano, 1954) has been shown to be a competitive inhibitor of all methyltransferases. This was first shown by Gibson et al.
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S-Adenosylhomocysteine (AdoHcy), first isolated as one of the products of transmethylation reactions from S-adenosylmethionine (AdoMet) (Cantoni & Scarano, 1954) has been shown to be a competitive inhibitor of all methyltransferases. This was first shown by Gibson et al.
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Kinetic Properties of Human Erythrocyte Adenosylhomocysteinase
1986SALERNO, Costantino +3 more
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Cancer research, 1981
9-beta-D-Arabinofuranosyladenine (ara-A), 9-beta-D-arabinofuranosyladenine 5'-monophosphate, and 9-beta-D-arabinofuranosyladenine 5'-triphosphate competitively inhibit both the synthesis and hydrolysis of S-adenosylhomocysteine catalyzed by S-adenosylhomocysteinase [S-adenosylhomocysteine hydrolase (EC 3.3.1.1)] from mouse liver, and the inhibitor ...
S, Helland, P M, Ueland
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9-beta-D-Arabinofuranosyladenine (ara-A), 9-beta-D-arabinofuranosyladenine 5'-monophosphate, and 9-beta-D-arabinofuranosyladenine 5'-triphosphate competitively inhibit both the synthesis and hydrolysis of S-adenosylhomocysteine catalyzed by S-adenosylhomocysteinase [S-adenosylhomocysteine hydrolase (EC 3.3.1.1)] from mouse liver, and the inhibitor ...
S, Helland, P M, Ueland
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