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Adenovirus Biology, Recombinant Adenovirus, and Adenovirus Usage in Gene Therapy [PDF]
Viruses, 2021 Gene therapy is currently in the public spotlight. Several gene therapy products, including oncolytic virus (OV), which predominantly replicates in and kills cancer cells, and COVID-19 vaccines have recently been commercialized. Recombinant adenoviruses,
Maki Watanabe +3 more
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Adenovirus Core Proteins: Structure and Function
Viruses, 2021 Adenoviruses have served as a model for investigating viral-cell interactions and discovering different cellular processes, such as RNA splicing and DNA replication.
Shermila Kulanayake, Suresh K. Tikoo
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Cytokine Responses to Adenovirus and Adenovirus Vectors
Viruses, 2022 The expression of cytokines and chemokines in response to adenovirus infection is tightly regulated by the innate immune system. Cytokine-mediated toxicity and cytokine storm are known clinical phenomena observed following naturally disseminated ...
Svetlana Atasheva +1 more
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Validation of a Laboratory-Developed Triplex Molecular Assay for Simultaneous Detection of Gastrointestinal Adenovirus and Rotavirus in Stool Specimens [PDF]
Pathogens, 2020 Enteric viral pathogens causing gastroenteritis include adenovirus and rotavirus, among others. Rotavirus is the leading cause of severe diarrhea in infants and young children worldwide.
Rachel R. Higgins +3 more
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Cellular Physiology and Biochemistry, 2017 Background/Aims: While recombinant adenoviruses are among the most widely-used gene delivery vectors and usually propagated in HEK-293 cells, generating recombinant adenoviruses remains time-consuming and labor-intense.
Qiang Wei +25 more
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Frontiers in Pediatrics, 2021 Objectives: To identify the differences of clinical characteristics and outcomes of severe pneumonia in children under 5 years old with and without adenovirus infection.Methods: A retrospective cohort study was conducted in three pediatric hospitals in ...
Lingling Zheng +8 more
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A Case Series of Children with Acute Hepatitis and Human Adenovirus Infection.
New England Journal of Medicine, 2022 BACKGROUND Human adenoviruses typically cause self-limited respiratory, gastrointestinal, and conjunctival infections in healthy children. In late 2021 and early 2022, several previously healthy children were identified with acute hepatitis and human ...
L. H. Gutierrez Sanchez +29 more
semanticscholar +1 more source
Pandemic influenza virus 2009 H1N1 and adenovirus in a high risk population of young adults: epidemiology, comparison of clinical presentations, and coinfection. [PDF]
PLoS ONE, 2014 BACKGROUND: In 2009, pandemic H1N1 influenza virus (2009 H1N1) emerged worldwide, causing morbidity and mortality that disproportionately affected young adults.
Heather C Yun +5 more
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Adenovirus Vectors: Excellent Tools for Vaccine Development
Immune Network, 2021 Adenovirus was originally used as a vector for gene therapy. In recent years, with the development of the next-generation vectors with increased safety and high immunogenicity to transgene products, its utility as a vaccine vector has continued to ...
Jun Chang
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Adenovirus Structure: What Is New?
International Journal of Molecular Sciences, 2021 Adenoviruses are large (~950 Å) and complex non-enveloped, dsDNA icosahedral viruses. They have a pseudo-T = 25 triangulation number with at least 12 different proteins composing the virion.
José Gallardo +3 more
semanticscholar +1 more source