Results 131 to 140 of about 35,791 (265)

Vaccinations During Pregnancy Protect the Mother–Infant Dyad and Are Generally Safe

Acta Paediatrica, EarlyView.
ABSTRACT Aim Vaccination in pregnancy has a critical impact on mothers, foetuses and infants. The aim of this paper was to summarise key points presented by experts attending the 12th Maria Delivoria‐Papadopoulos Perinatal Symposium in March 2025 and further expand and update them.
Ariadne Malamitsi‐Puchner, Despina D. Briana, Gian Carlo Di Renzo   +2 more
wiley   +1 more source

Desmoglein 2 (DSG2)-knockout human respiratory epithelial cell model to study species B adenovirus receptor usage. [PDF]

Virol Sin
Bahlmann N, Alshawabkeh M, Tsoukas R, Schröer K, Schellhorn S, Sieler M, Dittmar T, Ehrke-Schulz E, Ehrhardt A, Zhang W.   +9 more
europepmc   +1 more source

Spheroids reveal hypoxia‑driven spatial restriction of adenoviral infection. [PDF]

Sci Rep
Büttner T, Wang X, Krishnacoumar B, Papadamakis A, Cicek S, Schild Y, Winning S, Littwitz-Salomon E, Ehrhardt A, Dittmer U, Bayer W, Fandrey J, Malyshkina A.   +12 more
europepmc   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Identification of Novel Recombinant Human Adenovirus Genotype B117 from Pediatric Cases, China. [PDF]

Emerg Infect Dis
Wang J, Jing L, Duan Y, Guan X, Cui Y, Ai J, Wang R, Chen X, Bi Y, Liu X, Xu B, Zhu Y, Xie Z.   +12 more
europepmc   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

PLGA‐particle‐based vaccine induces SARS‐CoV‐2‐specific antibody and T‐cell responses

British Journal of Pharmacology, EarlyView.
A novel coronavirus disease 2019 (COVID‐19) vaccine encapsulating recombinant severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) spike receptor binding domain (RBD) with the double stranded RNA (dsRNA) analogue Riboxxim induces robust systemic and respiratory T‐ and B‐cell responses in mice.
Dennis Horvath, Katharina Inholz, Dennis Mink, Alicia Madel, Julia Koerner, Reinhold Horlacher, Michael Basler   +6 more
wiley   +1 more source

Identification of a novel fiber shaft structural motif and overexpression of key transcripts elucidated in human adenovirus D 10. [PDF]

PLoS Pathog
Mundy RM, Waraich K, Bates EA, Rizkallah PJ, Baker AT, Young MT, Morris E, da Fonseca PCA, Bliss CM, Matthews D, Bhella D, Parker AL.   +11 more
europepmc   +1 more source

Atrial natriuretic peptide counteracts aldosterone secretion by preventing acute angiotensin II‐induced cAMP signalling

British Journal of Pharmacology, EarlyView.
Background and Purpose Aldosterone plays a key role in blood pressure and volume regulation. Enhanced aldosterone secretion contributes to cardiovascular and renal diseases. Therefore, inhibitors of aldosterone receptors and synthase are essential drugs for the treatment of hypertension and heart failure.
Sanika Mohagaonkar, Egor B. Skryabin, Bettina M. Buchholz, Michaela Kuhn, Celso E. Gomez‐Sanchez, Stepan Gambaryan, Viacheslav O. Nikolaev   +6 more
wiley   +1 more source

Epidemiological analysis of six common respiratory pathogen infections in children in Chengdu from 2022 to 2024. [PDF]

Front Pediatr
Wang C, Luo M, Yang S.
europepmc   +1 more source