Results 181 to 190 of about 35,848 (258)

Design and Engineering of Recombinant Oncolytic Adenoviruses Expressing an Anti-EpCAM/Anti-CD3 BiTE for Targeted Immunotherapy of A549 Lung Cancer Cells. [PDF]

Onco Targets Ther
Taheri E, Abdoli S, Shahbazi M.
europepmc   +1 more source

Epidemiology, Genomic Diversity, and Evolutionary Dynamics of Human Metapneumovirus Over 7 Years of Integrated Community‐ and Hospital‐Based Sentinel Surveillance in Senegal, 2018–2024

Influenza and Other Respiratory Viruses, Volume 20, Issue 7, July 2026.
ABSTRACT Background In late 2024, a major human metapneumovirus (HMPV) outbreak in China caused widespread pneumonia and thousands of hospitalizations, drawing global attention to this virus. In Senegal, a concomitant rise in HMPV detections was observed in both community and hospital settings.
Mamadou Malado Jallow, Mamadou Aliou Barry, Ndeye Awa Ndiaye, Marie Pedepa Mendy, Mareme Seye Thiam, Safiétou Sankhe, Samba Niang Sagne, Ndiende Koba Ndiaye, Seynabou Mbaye Ba Souna Diop, Ndaraw Diack, Deborah Goudiaby, Cheikh Loucoubar, Amadou Alpha Sall, Moussa Moïse Diagne, Ndongo Dia   +14 more
wiley   +1 more source

Global Epidemiology of Human Adenoviruses, 2016-2024: A Pre- and Post-COVID-19 Analysis of Circulation Patterns and Epidemic Timing. [PDF]

Influenza Other Respir Viruses
Papini E, Bonaccorsi G, Bechini A, Berti F, Boccalini S, Bonanni P, Chiavarini M, Cosma C, Lorini C, Salvati C, Saviozzi V, Zanobini P, Caini S, Del Riccio M.   +13 more
europepmc   +1 more source

Context‐Dependent Effects of Apolipoprotein A2 on Lipid Metabolism and Atherogenesis

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Proposed model of the pro‐atherogenic role of APOA2 in dyslipidemia. Under conditions of dyslipidemia (ldlr−/− and apoe−/− mice), APOA2 promotes a reduction in VLDL through its conversion to LDL via an LDLR‐independent pathway. LDL is then deposited to the aorta and aortic root. In the ldlr−/− mice, the presence of APOE may mitigate the rate of VLDL to
Evangelia Zvintzou, Ioana Madalina Fenyo, Radu Ionita, Georgia Kakafoni, Madalina Dumitrescu, Maria Alemi, Bianca Sanziana Daraban, Konstantinos Marinos, Anca Violeta Gafencu, Kyriakos E. Kypreos   +9 more
wiley   +1 more source

Intrinsic immune properties of carrier MSC impact on the clinical outcome of children with solid tumors receiving oncolytic virotherapy. [PDF]

Exp Hematol Oncol
Morales-Molina A, Franco-Luzón L, Garcia-Rodriguez P, González-Murillo A, García-Castro J, Ramírez M.   +5 more
europepmc   +1 more source

Mechanism and Intervention of the NPY1R/CREB Signaling Axis in Regulating Inflammatory Response in Aged Ovarian Granulosa Cells and Ovarian Senescence

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Aging‐associated upregulation of NPY1R drives p‐CREB activation, triggering inflammation, mitochondrial dysfunction, and extracellular matrix imbalance to promote ovarian senescence. Pharmacological inhibition of NPY1R with BIBO 3304 restores ovarian homeostasis, highlighting a therapeutic strategy for reproductive aging. ABSTRACT Ovarian senescence is
Junnan Fang, Chaoying Wang, Shuaishuai Guo, Yiping Zhang, Yang Zhang, Huihui Wang, Yue Kong, Haixia Jin, Lin Qi, Yan Liu, Zhaoting Wu, Fuli Zhang, Shuang Wen, Xiaopeng Wang, Guang Yang, Guidong Yao   +15 more
wiley   +1 more source

Oncolytic adenoviruses in bladder and kidney cancers: emerging strategies and next frontiers. [PDF]

Front Microbiol
Yao J, Shayakhmetov DM.
europepmc   +1 more source

Encapsulin‐Protected Immunotherapeutic Complexes: Bacteria‐Derived Nanoparticles for mRNA Delivery to Eukaryotic Cells

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
Here, we introduce a biological, self‐assembling supramolecular nanoparticle designed to encapsulate eukaryotic‐expressible mRNA within an encapsulin shell via an encapsulin‐RNA adaptor peptide (ERAP). This process occurs in bacteria, and the resulting complex can deliver its mRNA into eukaryotic cells, where it is expressed.
Carlos Francisco Coffeen, Maribel Cayetano‐Cruz, Damaris Ilhuicatzi‐Alvarado, Carmen Méndez, Leticia Moreno‐Fierros, Ismael Bustos‐Jaimes   +5 more
wiley   +1 more source

Adenovirus phagocytosis by neutrophils triggers a pro-inflammatory response. [PDF]

PLoS Pathog
Laurans S, Huerre S, Dellis O, Férard C, Jalaber H, Vanbergue C, Brun E, Jelin R, Nüsse O, Benihoud K, Dupré-Crochet S.   +10 more
europepmc   +1 more source

Single versus repeated intravenous oncolytic reovirus infusions: Implications for immune modulation and rationalised scheduling of therapy in hepatocellular carcinoma

International Journal of Cancer, Volume 158, Issue 12, Page 3252-3267, 15 June 2026.
What's new? Oncolytic viruses are a promising immunotherapeutic approach against many malignancies. However, it is unclear whether repeated doses have improved therapeutic value or may trigger greater side effects, especially in patients with hepatocellular carcinoma whose liver is chronically damaged.
Karen J. Scott, Emma J. West, Rebecca J. Brownlie, Fay Ismail, Christy Ralph, Thomas Heineman, Matt Coffey, Alan A. Melcher, Alison Taylor, Salvatore Papa, Adel Samson   +10 more
wiley   +1 more source