Results 151 to 160 of about 68,807 (284)

Integrated ERK‐PKA‐YAP/TAZ‐SHH Signaling Orchestrates Cortical Radial Glia Identity and Lineage Diversification

Advanced Science, Volume 13, Issue 5, 27 January 2026.
This study shows that ERK/PKA upregulation in mammalian cortical radial glia (RGs) sustains neurogenesis and suppresses gliogenesis. YAP/TAZ activation promotes ependymal cell formation, while enhanced SHH‐SMO signaling induces astrocyte, oligodendrocytes, and olfactory bulb interneuron generation.
Zhuangzhi Zhang, Zhejun Xu, Tongye Fu, Jialin Li, Feihong Yang, Chuannan Yang, Wenhui Zheng, Zizhuo Sha, Yanjing Gao, Mengge Sun, Zhenmeiyu Li, Jing Ding, Xiaosu Li, Zhengang Yang   +13 more
wiley   +1 more source

Lack of ANKMY2 suppresses kidney cystogenesis in embryonic- and adult-onset polycystic kidney disease.

PLoS Genetics
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive bilateral cyst formation. Multiple cellular pathways including second messenger cAMP signaling are dysregulated in ADPKD, but mechanisms initiating cysts are unknown ...
Sun-Hee Hwang, Kyungsuk Choi, Hemant Badgandi, Kevin A White, Yu Xun, Owen M Woodward, Feng Qian, Saikat Mukhopadhyay   +7 more
doaj   +1 more source

Pituitary adenylyl cyclase-activating polypeptide is an intrinsic regulator of Treg abundance and protects against experimental autoimmune encephalomyelitis

, 2009
Yossan‐Var Tan, Catalina Abad, Robert Lopez, Hongmei Dong, Shen Liu, Alice W. Lee, Rosa P. Gomariz, Javier Leceta, James A. Waschek   +8 more
openalex   +1 more source

Ca ²⁺ -Stimulated Adenylyl Cyclase AC1 Generates Efficient Biological Pacing as Single Gene Therapy and in Combination With HCN2 [PDF]

, 2012
Gerard J.J. Boink, Bruce D. Nearing, Iryna N. Shlapakova, Lian Duan, Yelena Kryukova, Yevgeniy Bobkov, Hanno L. Tan, Ira S. Cohen, Peter Danilo, Richard B. Robinson, Richard L. Verrier, Michael R. Rosen   +11 more
openalex   +1 more source

Glutamate Receptors and Synaptic Plasticity in Health and Disease: A Personal Journey

Hippocampus, Volume 36, Issue 1, January 2026.
ABSTRACT I describe my progress in understanding synaptic plasticity in the hippocampus. Over the decades my lab has focused on the roles of glutamate receptors (AMPARs, NMDARs, mGluRs and KARs) and associated signaling molecules in LTP and LTD. Most of our studies have been conducted in area CA1 (Schaffer collateral—commissural pathway) with some ...
Graham L. Collingridge
wiley   +1 more source

Adenylyl cyclase 4 does not regulate collecting duct water and sodium handling [PDF]

, 2014
Wararat Kittikulsuth, Deborah Stuart, Donald E. Kohan   +2 more
openalex   +1 more source

There are more things in heaven and Earth than we dream of in our physiology

The Journal of Physiology, EarlyView.
Victor A. Maltsev, Michael D. Stern, Edward G. Lakatta   +2 more
wiley   +1 more source

From Synaptic Plasticity and Critical Periods to Social Behavior and Stress: Getting to, and Staying in, CA2

Hippocampus, Volume 36, Issue 1, January 2026.
ABSTRACT Hippocampal Area CA2, with some exceptions, had long been neglected in in vivo studies, due largely to its small size, and in in vitro studies because of its general similarity to CA3 and CA1. Increasing evidence showing that CA2 was molecularly distinct led to the increased appreciation of CA2 as a separate region, and as such, that it likely
Serena M. Dudek
wiley   +1 more source

Adenylyl cyclase 1 mitigates doxorubicin-induced cardiotoxicity by reducing oxidative stress and myocardial damage [PDF]

Le Zhang, Xin Li, Qingwen Zhang, Yanfei Li   +3 more
openalex   +1 more source

A CE assay for the detection of agonist‐stimulated adenylyl cyclase activity [PDF]

, 2007
Jennifer M. Cunliffe, Matthew R. Whorton, Roger K. Sunahara, Robert T. Kennedy   +3 more
openalex   +1 more source