Results 151 to 160 of about 134,365 (335)
American Journal of Physiology - Lung cellular and Molecular Physiology, 2009 Soluble adenylyl cyclase toxins, such as Pseudomonas aeruginosa exoY, generate a cAMP pool that retracts cell borders. However, the cytoskeletal basis by which this cAMP signal retracts cell borders is not known. We sought to determine whether activation
Nutan Prasain +3 more
semanticscholar +1 more source
British Journal of Pharmacology, Volume 182, Issue 14, Page 3044-3067, July 2025.Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi +6 more
wiley +1 more source
Gαq signalling from endosomes: A new conundrum
British Journal of Pharmacology, Volume 182, Issue 14, Page 3068-3089, July 2025.Abstract G‐protein‐coupled receptors (GPCRs) constitute the largest family of membrane receptors, and are involved in the transmission of a variety of extracellular stimuli such as hormones, neurotransmitters, light and odorants into intracellular responses.
Carole Daly, Bianca Plouffe
wiley +1 more source
Intestinal brush border membranes contain regulatory subunits of adenylyl cyclase. [PDF]
, 1987 Pedro Domı́nguez +3 more
openalex +1 more source
G protein‐coupled receptor‐mediated autophagy in health and disease
British Journal of Pharmacology, Volume 182, Issue 14, Page 3151-3162, July 2025.G protein‐coupled receptors (GPCRs) constitute the largest and most diverse superfamily of mammalian transmembrane proteins. These receptors are involved in a wide range of physiological functions and are targets for more than a third of available drugs in the market. Autophagy is a cellular process involved in degrading damaged proteins and organelles
Devrim Öz‐Arslan +2 more
wiley +1 more source
No evidence for oncogenic mutations in guanine nucleotide-binding proteins of human adrenocortical neoplasms [PDF]
, 1933 G-Proteins are membrane-bound heterotrimeric polypeptides that couple receptor signals to second messenger systems such as cAMP. Recently, point mutations at 2 codons of the highly preserved alpha-chain of Gs, the adenyl cyclase-stimulating G-protein ...
Chrousos, G. P. +3 more
core
PGE1 and hCG Responsive Adenylyl Cyclases in Interstitial Cells from Rat Testis: Biphasic Effects of Calcium [PDF]
, 1980 Jan O. Gordeladze +3 more
openalex +1 more source
Differential G protein activation by the long and short isoforms of the dopamine D2 receptor
British Journal of Pharmacology, Volume 182, Issue 14, Page 3336-3352, July 2025.Background and Purpose The dopamine D2 receptor is expressed as a short (D2S) and a long (D2L) isoform with 29 additional amino acids in the third intracellular loop. The D2S isoform shows higher presynaptic expression than the D2L isoform, and decreased D2S expression has recently been linked to an increased risk for schizophrenia.
David Reiner‐Link +4 more
wiley +1 more source
Effect of Estradiol Withdrawal on Luteal Hormone-Responsive Adenylyl Cyclase and Luteal Function in the Pseudopregnant Rabbit1 [PDF]
, 1980 Sharon L. Day +3 more
openalex +1 more source
Allosterism in the adenosine A2A and cannabinoid CB2 heteromer
British Journal of Pharmacology, Volume 182, Issue 14, Page 3371-3384, July 2025.Abstract Background and Purpose Allosterism is a regulatory mechanism for GPCRs that can be attained by ligand‐binding or protein–protein interactions with another GPCR. We have studied the influence of the dimer interface on the allosteric properties of the A2A receptor and CB2 receptor heteromer.
Claudia Llinas del Torrent +7 more
wiley +1 more source