Results 141 to 150 of about 36,489 (201)

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

Xanomeline and Trospium Chloride: Mechanism of Action, Clinical, and Translational Science

Clinical and Translational Science, Volume 19, Issue 9, September 2026.
ABSTRACT Xanomeline‐trospium chloride (Cobenfy, formerly KarXT) is a first‐in‐class, oral central M1/M4 muscarinic receptor agonist approved for the treatment of schizophrenia in adults. Cobenfy represents a paradigm shift by avoiding direct dopamine D2 receptor blockade and thus significantly reduces the burden of metabolic, extrapyramidal, and ...
Samantha Avila, Ingrid L. Chen
wiley   +1 more source

Synthesis and Biological Activity of 2,6‐Disubstituted and 2,6,9‐Trisubstituted 7‐Deazapurine Nucleobases

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Four series of 20 (het)aryl substituted 7‐deazapurine nucleobases were synthesized. Several potent antagonists of all four subtypes of adenosine receptors were identified by functional assay. High‐throughput screening of the IMTM compound library for modulatory activity on adenosine receptors (ARs) identified two deazapurine hits based on 2,6‐diaryl‐7 ...
Ugnė Šinkevičiūtė, Kateřina Burgetová Ječmeňová, Soňa Gurská, Lenka Poštová Slavětínská, Vincent Baran, Pavel Polishchuk, Petr Džubák, Michal Hocek, Marián Hajdúch, Michal Tichý   +9 more
wiley   +1 more source

An adenylyl cyclase that functions during late development of Dictyostelium

, 1999
A variety of extracellular signals lead to the accumulation of cAMP which can act as a second message within cells by activating protein kinase A (PKA).
Fuller, D, Söderbom, Fredrik,, Anjard, C, Iranfar, N, Loomis, W F   +4 more
core  

Editorial: Adenylyl cyclase isoforms as potential drug targets

Frontiers in Pharmacology, 2022
Tarsis F. Brust, Tarsis F. Brust, Rennolds S. Ostrom, Val J. Watts   +3 more
doaj   +1 more source

Soluble adenylyl cyclase

, 2018
\(\bf Aims\) In contrast to the membrane bound adenylyl cyclases, the soluble adenylyl cyclase (sAC) is activated by bicarbonate and divalent ions including calcium. sAC is located in the cytosol, nuclei and mitochondria of several tissues including cardiac muscle. However, its role in cardiac pathology is poorly understood. Here we investigate whether
Schirmer, Ilona, Bualeong, Tippaporn (Dr. rer. nat.), Budde, Heidi (M. Sc.), Cimiotti, Diana (Dr. rer. nat.), Appukuttan, Avinash (Dr. rer. nat.), Klein, Nicole (M. Sc.), Steinwascher, Philip (M.Sc.), Reusch, Hans-Peter (Prof. Dr. med.), Mügge, Andreas (Prof. Dr. med.), Meyer, Rainer (Apl. Prof. Dr. rer. nat.), Ladilov, Yuri, Jaquet, Kornelia (Prof. Dr. rer. nat.)   +11 more
openaire   +1 more source

Mitochondrial soluble adenylyl cyclase (sAC) cooperates with membrane adenylyl cyclase in the regulation of complex I turnover and activity.

, 2012
Domenico De Rasmo, Sergio Papa Mitochondrial soluble adenylyl cyclase sAC cooperates with membrane adenylyl cyclase in the regulation of complex I turnover, Giuseppe Capitanio, activity, Arcangela Santeramo, Anna Signorile   +5 more
core  

Olfactory adenylyl cyclase

Journal of Biological Chemistry, 1989
E Pfeuffer, S Mollner, D Lancet, T Pfeuffer   +3 more
openaire   +1 more source

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The adenylyl and guanylyl cyclase superfamily

Current Opinion in Structural Biology, 1998
New structures solved in 1997 revealed that the adenylyl cyclase core consists of a pair of catalytic domains arranged in a wreath. Homologous catalytic domains are arranged in diverse adenylyl and guanylyl cyclases as symmetric homodimers or pseudosymmetric heterodimers.
James Hurley
exaly   +3 more sources

Inhibition of human thyroid adenylyl cyclase by 2-iodoaldehydes

Molecular and Cellular Endocrinology, 1994
2-Iodohexadecanal (IHDA), which can be formed upon addition of iodine to the vinyl ether group of plasmalogens, has been identified as a major thyroid iodolipid (Pereira et al. (1990) J. Biol. Chem. 265, 17018-17025).
Valerie Panneels, J M Boeynaems, J E Dumont   +2 more
exaly   +1 more source