Results 131 to 140 of about 63,526 (247)

The organisation and functions of local Ca²⁺ signals [PDF]

, 2001
Calcium (Ca2+) is a ubiquitous intracellular messenger, controlling a diverse range of cellular processes, such as gene transcription, muscle contraction and cell proliferation.
Berridge, Michael J., Bootman, Martin D., Lipp, Peter   +2 more
core  

A role for epithelium‐derived 6‐nitrodopamine on human ureter contractility

British Journal of Pharmacology, Volume 183, Issue 10, Page 2360-2375, May 2026.
Abstract Background and Purpose To investigate the basal release of 6‐nitrodopamine (6‐ND) from human isolated ureter and the role of this novel catecholamine in the ureter contractility. Experimental Approach Ureters from 67 brain‐dead organ donors (40 males and 27 females) were used during kidney transplantation procedures.
Wilmar Azal Neto, Denis Lima Oliveira, José Britto‐Júnior, Alex Henrique Miller, Flaviano Lorenzon, Felipe Fernandes Jacintho, Valéria Barbosa de Souza, Fernanda Viviane Mariano, André Almeida Schenka, Fabiola Zakia Mónica, Adriano Fregonesi, Edson Antunes, Gilberto De Nucci   +12 more
wiley   +1 more source

Opioids in breast cancer: Between analgesia and modulation of tumour progression

British Journal of Pharmacology, Volume 183, Issue 9, Page 1727-1746, May 2026.
Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun, Anna Tankiewicz‐Kwedlo, Dariusz Pawlak   +2 more
wiley   +1 more source

The role of the neuromodulator adenosine in alcohols actions. [PDF]

, 1997
The interaction between the neuromodulator adenosine and adenosine receptors on the surface of neurons modifies the neurons responses to neurotransmitters.
Diamond, Ivan, Dohrman, D, Gordon, A
core  

Review: “The Disappointment Dilemma: Short‐ and Long‐Term Learning From Negative Outcomes”

European Journal of Neuroscience, Volume 63, Issue 9, May 2026.
The habenula routes negative‐outcome signals to VTA, RMTg, and IPN to shape aversive learning and motivation. The lateral habenula encodes acute negative prediction errors to rapidly adapt behavior to threat, fear, and avoidance. The medial habenula integrates repeated stress, drug, and aversive experiences into long‐term negative mood and expectations.
Ines Ibañez‐Tallon, Susanna Molas, Christophe D. Proulx, Joaquin Piriz, Edgar Soria‐Gómez   +4 more
wiley   +1 more source

Dissecting the mechanisms of learning-by-doing in Drosophila [PDF]

, 2007
At the heart of learning-by-doing lies a well-known psychological phenomenon: information will be remembered better if it is actively generated rather than passively read or heard. First described in humans, this generation effect can also be observed in
Bjö, Wolfgang Plendl
core   +1 more source

Lack of ANKMY2 suppresses kidney cystogenesis in embryonic- and adult-onset polycystic kidney disease.

PLoS Genetics
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive bilateral cyst formation. Multiple cellular pathways including second messenger cAMP signaling are dysregulated in ADPKD, but mechanisms initiating cysts are unknown ...
Sun-Hee Hwang, Kyungsuk Choi, Hemant Badgandi, Kevin A White, Yu Xun, Owen M Woodward, Feng Qian, Saikat Mukhopadhyay   +7 more
doaj   +1 more source

Using a Robust and Sensitive GFP-Based cGMP Sensor for Real-Time Imaging in Intact Caenorhabditis elegans. [PDF]

, 2019
cGMP plays a role in sensory signaling and plasticity by regulating ion channels, phosphodiesterases, and kinases. Studies that primarily used genetic and biochemical tools suggest that cGMP is spatiotemporally regulated in multiple sensory modalities ...
Ali, Nebat, Andersen, Kristine, Barsi-Rhyne, Benjamin, Brueggemann, Chantal, Costa, Wagner Steuer, Ferkey, Denise M, Futey, Mary, Gottschalk, Alexander, Hamilton, O Scott, Hill, Tyler, Krzyzanowski, Michelle C, L'Etoile, Noelle, Li, Joy, Mitchell, Jordan, Nagpal, Jatin, Schneider, Martin W, Sengupta, Piali, Shankar, Raakhee, Tran, Alan, VanHoven, Miri, Varshney, Aruna, Woldemariam, Sarah, Yu, Yanxun V   +22 more
core  

Soluble adenylyl cyclase

, 2018
\(\bf Aims\) In contrast to the membrane bound adenylyl cyclases, the soluble adenylyl cyclase (sAC) is activated by bicarbonate and divalent ions including calcium. sAC is located in the cytosol, nuclei and mitochondria of several tissues including cardiac muscle. However, its role in cardiac pathology is poorly understood. Here we investigate whether
Schirmer, Ilona, Bualeong, Tippaporn (Dr. rer. nat.), Budde, Heidi (M. Sc.), Cimiotti, Diana (Dr. rer. nat.), Appukuttan, Avinash (Dr. rer. nat.), Klein, Nicole (M. Sc.), Steinwascher, Philip (M.Sc.), Reusch, Hans-Peter (Dr. med.), Mügge, Andreas (Prof. Dr. med.), Meyer, Rainer (Apl. Prof. Dr. rer. nat.), Ladilov, Yuri, Jaquet, Kornelia (Prof. Dr. rer. nat.)   +11 more
openaire   +1 more source

Enhanced Myocardial Adenylyl Cyclase Activity Alters Heart-Brain Communication. [PDF]

JACC Clin Electrophysiol, 2023
Agrimi J, Menicucci D, Qu JH, Laurino M, Mackey CD, Hasnain L, Tarasova YS, Tarasov KV, McDevitt RA, Hoover DB, Gemignani A, Paolocci N, Lakatta EG.   +12 more
europepmc   +1 more source