Results 111 to 120 of about 84,347 (233)

Intracellular α1A‐adrenergic receptor regulation of cAMP production by an inside‐out mitogen‐activated protein kinase signalling pathway in cardiac myocytes

The Journal of Physiology, EarlyView.
Abstract figure legend Norepinephrine (NE) activates β‐adrenergic receptors (βARs) at the myocyte surface, where stimulatory G protein (Gs) and adenylyl cyclase (AC) produce cAMP. NE also enters the cell via the organic cation transporter (OCT3) and activates intracellular α1A‐adrenergic receptors (α1AAR), possibly in the nucleus.
Chase M. Fiore, Michael W. Rudokas, Riko Masuda, Brandon Khamsopha, Rinzhin T. Sherpa, Nisha Chouhan, Karni S. Moshal, Shailesh R. Agarwal, Robert D. Harvey   +8 more
wiley   +1 more source

An M2 muscarinic receptor subtype coupled to both adenylyl cyclase and phosphoinositide turnover

, 1987
To investigate whether a particular receptor subtype can be coupled to multiple effector systems, recombinant M2 muscarinic receptors were expressed in cells lacking endogenous receptor.
Capon, D. J., Schimerlik, M. I., Ramachandran, J., Winslow, J. W., Peterson, G. L., Ashkenazi, A., Peralta, E. G., Gary L. Peterson, Avi Ashkenazi, Ernest G. Peralta, Michael I. Schimerlik, Daniel J. Capon, John W. Winslow, Janakiraman Ramachandran   +13 more
core   +1 more source

The catalytic domains of thiamine triphosphatase and CyaB-like adenylyl cyclase define a novel superfamily of domains that bind organic phosphates

BMC Genomics, 2002
Background The CyaB protein from Aeromonas hydrophila has been shown to possess adenylyl cyclase activity. While orthologs of this enzyme have been found in some bacteria and archaea, it shows no detectable relationship to the classical nucleotide ...
Aravind L, Iyer Lakshminarayan M
doaj   +1 more source

Mechanism of Pingchuanning in Attenuating Asthma Based on UHPLC‐Q‐Orbitrap HRMS and Network Pharmacology Analysis

Biomedical Chromatography, Volume 40, Issue 12, December 2026.
ABSTRACT An ultrahigh‐performance liquid chromatography coupled with quadrupole‐Orbitrap high‐resolution mass spectrometry (UHPLC‐Q‐Orbitrap HRMS) method was applied to characterize Pingchuanning (PCN) decoction and its absorbed serum constituents in asthmatic rats.
Yue Zhang, Yiwen Ding, Weidong Chen, Yuanbo Bi, Yanyan Wang, Weidong Ye, Xiangming Fang   +6 more
wiley   +1 more source

Identification of a G(iα) binding site on type V adenylyl cyclase [PDF]

, 1998
The stimulatory G protein α subunit G(sα) binds within a cleft in adenylyl cyclase formed by the α1-α2 and α3-β4 loops of the C2 domain. The pseudosymmetry of the C1 and C2 domains of adenylyl cyclase suggests that the homologous inhibitory α subunit G ...
Tesmer, John J.G., Sprang, Stephen R., Gilman, Alfred G., Dessauer, Carmen W.   +3 more
core  

Comparative proteomic analysis of bone marrow mononuclear cells and peripheral blood mononuclear cells for autologous therapeutic implantation in chronic wounds

Clinical and Translational Discovery, Volume 6, Issue 6, December 2026.
• Integrative evaluation with proteomic analysis of mononuclear cells (MNC) from bone marrow (BM) or peripheral blood (PB) sources for autologous cell implantation in patients with chronic wounds sheds light on molecular differences and clinical outcomes. • BM‐MNC and PB‐MNC exhibited distinct and source‐specific proteomic signatures.
Farina Mohamad Yusoff, Nor Azfa Johari, Masato Kajikawa, Sharifah Zakiah Syed Sulaiman, Harikrishna K R Nair, Sze‐Piaw Chin, Shinji Kishimoto, Tatsuya Maruhashi, S Fadilah S Abdul Wahid, Yukihito Higashi   +9 more
wiley   +1 more source

Incretin‐Based Therapies as Cardiometabolic Interventions: Outcome Hierarchy, Receptor‐Network Pharmacology and Phenotype‐Based Clinical Positioning

Diabetes, Obesity and Metabolism, Volume 28, Issue 12, Page 10977-10991, December 2026.
ABSTRACT Aims Incretin‐based pharmacotherapy was initially developed to improve glucose‐dependent insulin secretion and glycaemic control in type 2 diabetes, but its clinical interpretation has expanded substantially with cardiovascular outcome trials, kidney outcome data, obesity studies and next‐generation polyagonist development.
Ferenc Sztanek, Hajnalka Lőrincz, Mariann Harangi, Attila Csaba Nagy   +3 more
wiley   +1 more source

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, Volume 27, Issue 12, December 2026.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

Differential expression of adenylyl cyclase subtypes in human cardiovascular system

, 2004
In human myocardium, β 1-adrenoceptor stimulation achieves maximal inotropic response but less than 50% of maximal adenylyl cyclase activation, whereas the reverse is true of the β 2-adrenoceptor.
Brown, M. J., Wang, T., M.J Brown, T Wang   +3 more
core   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, Volume 13, Issue 63, 12 November 2026.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source