Results 121 to 130 of about 39,778 (252)
Pancreatic Islet Cell Crosstalk: Insight Into α‐/β‐Cell Compensatory Mechanisms
Comprehensive Physiology, Volume 16, Issue 3, June 2026.α‐cell remodeling compensates for impaired β‐cell function. Intra‐islet glucagon/GLP‐1 signaling is upregulated and becomes essential in prediabetic islets. Flexible receptor engagement reflects functional plasticity in hormonal control of insulin secretion. Created in BioRender. Plecita, L. (2026); https://BioRender.com/pgjjg3m.
Štěpánka Benáková +5 more
wiley +1 more source
, 1984 The effects of chronic uremia and glucagon administration on glucagon-stimulable adenylyl cyclase in rat liver were assessed by determinations of adenylyl cyclase activities, specific iodoglucagon binding, and the activity of the stimulatory regulatory ...
Birnbaumer, L. +7 more
core +1 more source
Comprehensive Physiology, Volume 16, Issue 3, June 2026.Estrogen modulates β‐AR signaling in a context‐dependent manner influenced by species, sex, age, tissue, and vascular health, highlighting challenges in translating findings from experimental models to human cardiovascular physiology. ABSTRACT Cardiovascular diseases remain the leading global cause of morbidity and mortality, with notable sex‐specific ...
Basant Elsaid +5 more
wiley +1 more source
Biochemical pharmacology of adenylyl cyclases in cancer
Biochemical PharmacologyGlobally, despite extensive research and pharmacological advancement, cancer remains one of the most common causes of mortality. Understanding the signaling pathways involved in cancer progression is essential for the discovery of new drug targets. The adenylyl cyclase (AC) superfamily comprises glycoproteins that regulate intracellular signaling and ...
Jena, Bikash Chandra +3 more
openaire +2 more sources
Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1565-1573, June 2026.There is a paucity of data regarding the effects of prenatal disease‐modifying therapies (DMTs) for multiple sclerosis (MS), on congenital anomalies in the offspring. Moreover, data on the association with neurodevelopmental disorders are lacking. This is an historical cohort study, within the Israeli Clalit Health Services database (2005–2024) that ...
Bar Rosh +4 more
wiley +1 more source
Differential expression of adenylyl cyclase subtypes in human cardiovascular system
, 2004 In human myocardium, β 1-adrenoceptor stimulation achieves maximal inotropic response but less than 50% of maximal adenylyl cyclase activation, whereas the reverse is true of the β 2-adrenoceptor.
Brown, M. J., Wang, T.
core +1 more source
eFood, Volume 7, Issue 3, June 2026.Cubebene‐related sesquiterpenes, found across diverse biological sources, exhibit promising pharmacological activities, including anti‐inflammatory, neuroprotective, and anticancer effects. This review highlights their molecular diversity, ADME profiles, and predicted multitarget interactions, underscoring their therapeutic relevance and potential in ...
Khadija Boualam +4 more
wiley +1 more source
Biochemical characterization of photoactivated adenylyl cyclase from Naegleria gruberi
, 2014 Blue light sensors using FAD (BLUF) domains are flavin based blue light photoreceptors. The BLUF domains are often fused with various effector domains.
Kateriya, Suneel +5 more
core
Specific activation of adenylyl cyclase V by a purinergic agonist
, 1998 The present study was designed to investigate whether and how the purinergic stimulation of rat ventricular myocytes modulates the cAMP-dependent pathway.
Jaconi, Marisa +7 more
core +1 more source
There are more things in heaven and Earth than we dream of in our physiology
The Journal of Physiology, EarlyView.
Victor A. Maltsev +2 more
wiley +1 more source