Results 121 to 130 of about 84,347 (233)

Isolation, Structural Elucidation, and Anti‐Melanogenic Activity of a Novel Pectic Polysaccharide From Alhagi camelorum Fisch

Chemistry &Biodiversity, Volume 23, Issue 11, November 2026.
Polysaccharide extraction from Alhagi camelorum Fisch. was optimized, yielding ACP‐II‐1, a novel GalA‐rich, HG‐dominant pectin (26.145 kDa) containing branched RG‐I domains. ACP‐II‐1 reduced melanogenesis in forskolin‐stimulated B16F10 cells and a zebrafish model.
Zhitao Liu, Shuyan Han, Nannan Xu, Nuermaimaiti Abudukelimu, Jiangyu Zhao   +4 more
wiley   +1 more source

Dietary Polyphenols as Regulators of Protein Deposition and Muscle Health: Mechanisms, Interactions, and Functional Applications

Food Science &Nutrition, Volume 14, Issue 11, November 2026.
Dietary polyphenols contribute to the regulation of protein deposition and muscle health through multiple interconnected mechanisms. They promote protein synthesis and myogenic differentiation mainly by modulating the PI3K/AKT/mTOR signaling pathway and myogenic regulatory factors, while suppressing excessive protein degradation through regulation of ...
Chen Liu, Mengyi Ren, Xin Lai, Ke Gu, Liqiang Tan, Aimin Wu, Daiwen Chen   +6 more
wiley   +1 more source

Biochemical pharmacology of adenylyl cyclases in cancer

Biochemical Pharmacology
Globally, despite extensive research and pharmacological advancement, cancer remains one of the most common causes of mortality. Understanding the signaling pathways involved in cancer progression is essential for the discovery of new drug targets. The adenylyl cyclase (AC) superfamily comprises glycoproteins that regulate intracellular signaling and ...
Jena, Bikash Chandra, Flaherty, Daniel P., O’Brien, Valerie P., Watts, Val J.   +3 more
openaire   +2 more sources

The Efferocytosis‐Driven Macrophage Polarization: A Concerto in the Tumor Immunosuppressive Microenvironment

MedComm, Volume 7, Issue 11, November 2026.
Efferocytosis is a key process for macrophages to clear apoptotic cells, which undergoes the “ Find Me” chemotaxis signal stage, the “eat me” phagocytosis recognition stage and the “digest me” digestion stage in turn. During the aforementioned three stages, various signaling molecules released by apoptotic cells can promote the phenotypic polarization ...
Qiuping Chen, Chunzhi Wu, Changquan Huang, Hang Zhou   +3 more
wiley   +1 more source

Identification of Novel Interacting Proteins of FUZ and GPR161

PROTEOMICS, Volume 26, Issue 11, Page 64-74, November 2026.
ABSTRACT Protein–protein interactions are central to the dynamic regulation of signaling pathways and provide critical insight into the cellular mechanisms underlying human disease. Our previous study demonstrated biochemical and genetic interactions between FUZ and GPR161 in sonic hedgehog signaling during spinal neural tube development. In this study,
Gabriella Salazar, Anna Battenhouse, Andrew J. Kim, Sung‐Eun Kim   +3 more
wiley   +1 more source

A Cilia–Centered Nicotinamide Adenine Dinucleotide (NAD+) Signaling Network Regulates Hypothalamic Lysosomal Homeostasis and Metabolic Aging

Aging Cell, Volume 25, Issue 11, November 2026.
Aging‐associated NAD+ depletion in hypothalamic neurons shortens primary cilia and disrupts CHMP4B trafficking to lysosomes during lysosomal stress, leading to impaired TRPML1–mediated Ca2+ signaling and lysosomal stress responses. Calorie restriction restores hypothalamic NAD+ levels, ciliary structure, and lysosomal homeostasis, thereby improving ...
Se Eun Park, Eun Roh, Jae Woo Park, Seong Jun Kim, So Yeon Jeong, Chae Beom Park, Hyo Sun Lim, Ji Soo Kim, Mun Gyeom Kim, Myeong Ju Kim, Young In Cho, Wontae Jeong, Gil Myoung Kang, Sang‐Yeob Kim, Se Hee Min, Min‐Seon Kim   +15 more
wiley   +1 more source

Tubulin-G protein interaction: The dynamic role of tubulin in the regulation of the neuronal adenylyl cyclase.

, 1990
Tubulin-G protein interaction: The dynamic role of tubulin in the regulation of the neuronal adenylyl ...
Nan. Wang (7984148)
core   +3 more sources

Inhibition of adenylyl cyclase type 5 prevents L-DOPA-induced dyskinesia in an animal model of Parkinson's disease

, 2017
Adenylyl cyclase; Dyskinesia; L-DOPA; Parkinson's ...
한평림
core   +1 more source

DEFECT IN POTENTIATION OF ADENYLYL-CYCLASE CORRELATES WITH BRONCHIAL HYPERREACTIVITY

, 1995
Background: Adenylyl cyclase is a transmembrane signaling system involved in the inhibition of cellular responses. Recently, we showed that the activity of adenylyl cyclase may be potentiated by stimuli that induce an increase of cellular responses but ...
WEERSINK, EJM, KAUFFMAN, KF, DOOPER, MWSM, DEMONCHY, JGR   +3 more
core   +1 more source

GABAergic Network Dysregulation in Alcohol Use Disorder: Receptor–Transporter Interactions Driving the Transition From Goal‐Directed to Compulsive Behaviour

Addiction Biology, Volume 31, Issue 11, November 2026.
Astrocytic GAT3 regulates ambient GABA levels in the globus pallidus externus (GPe). Reduced GAT3 function enhances extrasynaptic GABAergic signalling and disrupts subthalamic nucleus (STN) regulation and cortical signal fidelity.ABSTRACTAlcohol use disorder (AUD) is characterized by a shift from controlled, goal‐directed drinking to compulsive ...
Hannah Aranda, Nathan Jones, Humza Haroon, Doo‐Sup Choi   +3 more
wiley   +1 more source