Results 161 to 170 of about 68,807 (284)

G Protein‐Coupled Receptor Kinase 5 (GRK5) Modulates Nociceptin/Orphanin FQ Opioid (NOP) Receptor Desensitization in Rat Sympathetic Neurons

Journal of Neuroscience Research, Volume 104, Issue 1, January 2026.
ABSTRACT Stimulation of nociceptin/orphanin FQ peptide (NOP) opioid receptors by the endogenous ligand nociceptin (Noc) leads to voltage‐gated Ca2+ channel inhibition or G protein inwardly rectifying K+ channel activation. One mechanism of G protein‐coupled receptor (GPCR) desensitization occurs when G protein‐coupled receptor kinases (GRK ...
Mohamed Farrag, Marwa Soliman, Saifeldin Mahmoud, Lauren Miller, Paul B. Herold, Kristen Brandt, Victor Ruiz‐Velasco   +6 more
wiley   +1 more source

Enhanced Myocardial Adenylyl Cyclase Activity Alters Heart-Brain Communication. [PDF]

JACC Clin Electrophysiol, 2023
Agrimi J, Menicucci D, Qu JH, Laurino M, Mackey CD, Hasnain L, Tarasova YS, Tarasov KV, McDevitt RA, Hoover DB, Gemignani A, Paolocci N, Lakatta EG.   +12 more
europepmc   +1 more source

Distribution of adenylyl cyclase/cAMP phosphodiesterase gene, CAPE, in streptophytes reproducing via motile sperm [PDF]

, 2021
Chiaki Yamamoto, Fumio Takahashi, Yosuke Ooe, Haruto Shirahata, Aika Shibata, Masahiro Kasahara   +5 more
openalex   +1 more source

CO2/HCO3−- and Calcium-regulated Soluble Adenylyl Cyclase as a Physiological ATP Sensor [PDF]

, 2013
Jonathan H. Zippin, Yanqiu Chen, Susanne G. Straub, Kenneth C. Hess, Ana Díaz, Dana Lee, Patrick Tso, George G. Holz, Geoffrey W.G. Sharp, Lonny R. Levin, Jochen Buck   +10 more
openalex   +1 more source

Targeting ecto‐5′‐nucleotidase (CD73) and cAMP alleviates carotid body hyperactivity and reduces blood pressure in chronically hypoxic rats

The Journal of Physiology, Volume 604, Issue 1, Page 626-652, 1 January 2026.
Abstract figure legend CD73 promotes carotid body hyperactivity in chronically hypoxic animals. Exposure to chronic hypoxia (CH) (FiO2 of 12% for 10 days) increases the proportion of CD73+TH+ cells in the carotid body and induces basal chemoafferent hyperactivity.
Demitris Nathanael, Andrew M. Coney, Dhaifallah Alotaibi, Prem Kumar, Andrew P. Holmes   +4 more
wiley   +1 more source

Phosphorylation of the δ-Opioid Receptor Regulates Its β-Arrestins Selectivity and Subsequent Receptor Internalization and Adenylyl Cyclase Desensitization [PDF]

, 2007
Yu Qiu, Horace H. Loh, Ping‐Yee Law
openalex   +1 more source

Inhibition of calcium-stimulated adenylyl cyclase subtype 1 (AC1) for the treatment of neuropathic and inflammatory pain in adult female mice [PDF]

, 2021
Zhaoxiang Zhou, Wantong Shi, Kexin Fan, Man Xue, Si-Bo Zhou, Qi‐Yu Chen, Jing-Shan Lu, Xu‐Hui Li, Min Zhuo   +8 more
openalex   +1 more source

Regulation of IKs Potassium Current by Isoproterenol in Adult Cardiomyocytes Requires Type 9 Adenylyl Cyclase [PDF]

, 2019
Yong Li, Thomas Hof, Tanya A. Baldwin, Lei Chen, Robert S. Kass, Carmen Dessauer   +5 more
openalex   +1 more source

Nicotiflorin Alleviates Obesity by Activating Brown Adipose Tissue Through the β3–Adrenergic Receptor Pathway

Advances in Pharmacological and Pharmaceutical Sciences, Volume 2026, Issue 1, 2026.
Objective This study investigated the antiobesity effects of nicotiflorin, a flavonol glycoside structurally related to rutin, by examining its ability to activate brown adipose tissue (BAT) through the β3–adrenergic receptor (β3‐AR) pathway in mice with high‐fat diet (HFD)–induced obesity.
Chun-Yen Chiu, Chung-Yuh Tzeng, Shin-Wu Liu, Chun-Jung Chen, Yu-Hsiang Kuan, Chung-Chi Hu, Wen-Ying Chen, Kim Wei Chan   +7 more
wiley   +1 more source

Soluble adenylyl cyclase

, 2018
\(\bf Aims\) In contrast to the membrane bound adenylyl cyclases, the soluble adenylyl cyclase (sAC) is activated by bicarbonate and divalent ions including calcium. sAC is located in the cytosol, nuclei and mitochondria of several tissues including cardiac muscle. However, its role in cardiac pathology is poorly understood. Here we investigate whether
Schirmer, Ilona, Bualeong, Tippaporn (Dr. rer. nat.), Budde, Heidi (M. Sc.), Cimiotti, Diana (Dr. rer. nat.), Appukuttan, Avinash (Dr. rer. nat.), Klein, Nicole (M. Sc.), Steinwascher, Philip (M.Sc.), Reusch, Hans-Peter (Dr. med.), Mügge, Andreas (Prof. Dr. med.), Meyer, Rainer (Apl. Prof. Dr. rer. nat.), Ladilov, Yuri, Jaquet, Kornelia (Prof. Dr. rer. nat.)   +11 more
openaire   +1 more source