Results 81 to 90 of about 102,595 (300)

The integrated model of cAMP-dependent DNA expression reveals an inverse relationship between cancer and neurodegeneration [PDF]

arXiv, 2016
The model for cAMP-dependent synaptic plasticity relates the characterization of a noradrenaline-stimulated adenylyl cyclase with DNA unzipping. Specific proteins condition cAMP insertion in specific sites of the DNA structure to direct cellular and synaptic differentiation in brain tissues, also providing coding. Metabolic-dependent ATP binding of Mg2+
arxiv  

Recent Developments in the Optical Control of Adrenergic Signaling

Medicinal Research Reviews, EarlyView.
ABSTRACT Adrenoceptors (ARs) play a vital role in various physiological processes and are key therapeutic targets. The advent of optical control techniques, including optogenetics and photopharmacology, offers the potential to modulate AR signaling with precise temporal and spatial resolution. In this review, we summarize the latest advancements in the
Shuang Shi, Yangzhi Cao, Maikel Wijtmans, Henry F. Vischer, Rob Leurs   +4 more
wiley   +1 more source

Stimulatory effects of adenosine on prolactin secretion in the pituitary gland of the rat

Brazilian Journal of Medical and Biological Research, 2002
We investigated the effects of adenosine on prolactin (PRL) secretion from rat anterior pituitaries incubated in vitro. The administration of 5-N-methylcarboxamidoadenosine (MECA), an analog agonist that preferentially activates A2 receptors, induced a ...
D.L.W. Picanço-Diniz, M.M. Valença, A.L.V. Favaretto, J. Antunes-Rodrigues   +3 more
doaj   +1 more source

Characterization of the norepinephrine-activation of adenylate cyclase suggests a role in memory affirmation pathways. Overexposure to epinephrine inactivates adenylate-cyclase,a causal pathway for stress-pathologies [PDF]

BioSystems 100 (2010) p. 87-93, 2010
Incubation with noradrenaline (norepinephrine) of isolated membranes of rat's brain corpus striatum and cortex, showed that ionic-magnesium (Mg2+) is required for the neurotransmitter activatory response of Adenylate Cyclase [ATP pyrophosphate-lyase (cyclizing), (EC 4.6.1.1)], AC.An Mg2+-dependent response to the activatory effects of adrenaline, and ...
arxiv  

Obesity, White Adipose Tissue, and Adipokines Signaling in Male Reproduction

Molecular Nutrition &Food Research, EarlyView.
Role of adipokines in the hypothalamic‐pituitary‐gonadal axis (HPG) during obesity. Obesity induces structural and functional changes in WAT, with a consequent imbalance in the production and secretion of adipokines. While the adipokines adiponectin and omentin‐1 are downregulated, the adipokines leptin, resistin, vifastin, apelin, and chemerin are ...
Fabiane Ferreira Martins, Maria do Socorro Medeiros Amarante, Daiana Santana Oliveira, Isabela Macedo Lopes Vasques‐Monteiro, Vanessa Souza‐Mello, Julio Beltrame Daleprane, Christina da Silva Camillo   +6 more
wiley   +1 more source

Induction of RAGE shedding by activation of G protein-coupled receptors. [PDF]

PLoS ONE, 2012
The multiligand Receptor for Advanced Glycation End products (RAGE) is involved in various pathophysiological processes, including diabetic inflammatory conditions and Alzheimers disease.
Verena V Metz, Elzbieta Kojro, Dorothea Rat, Rolf Postina   +3 more
doaj   +1 more source

Light Modulation of Cellular cAMP by a Small Bacterial Photoactivated Adenylyl Cyclase, bPAC, of the Soil Bacterium Beggiatoa*♦

Journal of Biological Chemistry, 2010
The recent success of channelrhodopsin in optogenetics has also caused increasing interest in enzymes that are directly activated by light. We have identified in the genome of the bacterium Beggiatoa a DNA sequence encoding an adenylyl cyclase directly ...
Manuela Stierl, Patrick S. Stumpf, Daniel Udwari, R. Gueta, R. Hagedorn, A. Losi, W. Gärtner, L. Petereit, Marina Efetova, Martin Schwarzel, T. Oertner, G. Nagel, P. Hegemann   +12 more
semanticscholar   +1 more source

Investigating the Mechanism of Conditioning Versus Postoperative Electrical Stimulation to Enhance Nerve Regeneration: One Therapy, Two Distinct Effects

Muscle &Nerve, EarlyView.
ABSTRACT Regeneration after peripheral nerve injury is often insufficient for functional recovery. Postoperative electrical stimulation (PES) following injury and repair significantly improves clinical outcomes; recently, conditioning electrical stimulation (CES), delivered before nerve injury, has been introduced as a candidate for clinical ...
Paige B. Hardy, Bonnie Y. Wang, K. Ming Chan, Christine A. Webber, Jenna‐Lynn B. Senger   +4 more
wiley   +1 more source

Pathways-driven Sparse Regression Identifies Pathways and Genes Associated with High-density Lipoprotein Cholesterol in Two Asian Cohorts [PDF]

arXiv, 2013
Standard approaches to analysing data in genome-wide association studies (GWAS) ignore any potential functional relationships between genetic markers. In contrast gene pathways analysis uses prior information on functional structure within the genome to identify pathways associated with a trait of interest. In a second step, important single nucleotide
arxiv  

Expression of adenylyl cyclase isoforms in neutrophils

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2003
In the present study, we have identified the expression of adenylyl cyclase (AC) isoforms in rat neutrophils according to the mRNA analysis and the distinct mode of regulation of isoform activity. Agarose gel electrophoresis of reverse transcription-polymerase chain reaction (RT-PCR)-amplified products resulted in a single band of the expected size for
Ling-Chu Chang, Yi-Lee Lin, Jih-Pyang Wang, Chung-Jieh Wang   +3 more
openaire   +3 more sources