Results 71 to 80 of about 84,347 (233)

Hepatocyte‐Centered Regulation of MASH Fibrosis: From Animal Models to Molecular Mechanisms and Targeted Therapies

iNew Medicine, EarlyView.
This review highlights hepatocytes as active regulators of MASH fibrosis through secreted proteins, metabolites, and extracellular vesicles that modulate hepatic stellate cell activation. These hepatocyte–stellate cell communication pathways provide a mechanistic framework for developing targeted antifibrotic therapies, including hepatocyte‐directed ...
Eui Jung Jung, Xiaobo Wang
wiley   +1 more source

GTPγS Regulation of a 12-Transmembrane Guanylyl Cyclase Is Retained after Mutation to an Adenylyl Cyclase [PDF]

, 2001
DdGCA is a Dictyostelium guanylyl cyclase with a topology typical for mammalian adenylyl cyclases containing 12 transmembrane-spanning regions and two cyclase domain.
Van Haastert, PJM, Roelofs, J, Loovers, Harriet   +2 more
core   +1 more source

Resistin and adenylyl cyclase-associated protein 1 (CAP1) regulate the expression of genes related to insulin resistance in BNL CL.2 mouse liver cells

Data in Brief, 2019
Resistin is an adipokine produced in white adipose tissue that is thought to modulate insulin sensitivity in peripheral tissues (such as liver, skeletal muscle or adipose tissue). Human and murine resistin molecules share only about 60% sequence homology.
Dimiter Avtanski, Karin Chen, Leonid Poretsky   +2 more
doaj   +1 more source

6‐Nitrodopamine as a Novel Mediator of Prostatic Smooth Muscle Function in Mouse and Human

Andrology, EarlyView.
ABSTRACT Background Epithelium‐derived catecholamines contribute to local regulation of genitourinary smooth muscle function, but the role of the endogenous 6‐nitrodopamine (6‐ND) in the prostate remains unknown. Objectives To determine whether 6‐ND is produced by mouse and human prostate and its role in smooth muscle regulation.
Alline Araujo Curiel, Fabio Henrique da Silva, Jéssica Mariana Dias, Luise Gabriela Santos Pereira, Douglas Rafael Martins Dias, Amanda Bueno Olivotti, André Almeida Schenka, Valéria Barbosa de Souza, Masato Tsutsui, Fabiola Zakia Monica, Edson Antunes, Gilberto De Nucci, Mariana G. de Oliveira   +12 more
wiley   +1 more source

Label-free fluorescent real-time monitoring of adenylyl cyclase

, 2010
In cellular signaling, adenylyl cyclase plays a key role in the hydrolysis of ATP to cyclic AMP and pyrophosphate. Using a synthetic fluorescent chemosensor (PyDPA) which binds strongly to the pyrophosphate group, we have developed a label-free ...
Kim, Kyoung-Shim, Han, Pyung-Lim, Rhee, Hyun-Woo, Hong, Jong-In, 한평림, 김경심, Kyoung-Shim Kim, Hyun-Woo Rhee, Pyung-Lim Han, Jong-In Hong   +9 more
core   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Function of Adenylyl Cyclase in Heart: the AKAP Connection

Journal of Cardiovascular Development and Disease, 2018
Cyclic adenosine monophosphate (cAMP), synthesized by adenylyl cyclase (AC), is a universal second messenger that regulates various aspects of cardiac physiology from contraction rate to the initiation of cardioprotective stress response pathways.
Tanya A. Baldwin, Carmen W. Dessauer
doaj   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Identification of essential residues for binding and activation in the human 5-HT7(a) receptor by molecular modeling and site-directed mutagenesis

Frontiers in Behavioral Neuroscience, 2015
The human 5-HT7 receptor is expressed in both the central nervous system and peripheral tissues and is a potential drug target in behavioral and psychiatric disorders.We examined molecular determinants of ligand binding and G protein activation by the ...
Agata Antonina Rita eImpellizzeri, Agata Antonina Rita eImpellizzeri, Agata Antonina Rita eImpellizzeri, Agata Antonina Rita eImpellizzeri, Matteo ePappalardo, Matteo ePappalardo, Livia eBasile, Ornella eManfra, Ornella eManfra, Ornella eManfra, Kjetil Wessel Andressen, Kjetil Wessel Andressen, Kjetil Wessel Andressen, Kurt Allen Krobert, Kurt Allen Krobert, Kurt Allen Krobert, Angela eMessina, Angela eMessina, Finn Olav eLevy, Finn Olav eLevy, Finn Olav eLevy, Salvatore eGuccione   +21 more
doaj   +1 more source

PDE4D and PDE3B orchestrate distinct cAMP microdomains in 3T3‐L1 adipocytes

British Journal of Pharmacology, EarlyView.
Basal conditions: •Ins/PDE3B lowers cytoplasmic cAMP (cyt‐cAMP) without affecting plasma membrane cAMP (pm‐cAMP). •Insulin decreases lipid droplet cAMP (LD‐cAMP) independent of PDE3B. •FGF1/PDE4D modestly reduces both cyt‐ and pm‐cAMP, while PDE4D alone can modulate LD‐cAMP. ISO stimulation: •Ins/PDE3B has minimal impact on cyt‐cAMP.
Johannes Krier, David Spähn, David Arturo Juarez Lopez, Judith L. Nono, Judith Seigner, Lisa Jacob, Siegfried Ussar, Robert Lukowski, Andreas L. Birkenfeld, Gencer Sancar   +9 more
wiley   +1 more source