Results 51 to 60 of about 33,547 (160)

Resistin and adenylyl cyclase-associated protein 1 (CAP1) regulate the expression of genes related to insulin resistance in BNL CL.2 mouse liver cells

Data in Brief, 2019
Resistin is an adipokine produced in white adipose tissue that is thought to modulate insulin sensitivity in peripheral tissues (such as liver, skeletal muscle or adipose tissue). Human and murine resistin molecules share only about 60% sequence homology.
Dimiter Avtanski, Karin Chen, Leonid Poretsky   +2 more
doaj   +1 more source

Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase

Nature Communications, 2018
It is unclear whether GPCRs, G proteins and adenylyl cyclase (AC) associate through random collisions or defined pre-coupling mechanisms. Using a peptide-based approach, the authors show that heteromers of adenosine A2A and dopamine D2 receptors form pre-
Gemma Navarro, Arnau Cordomí, Verónica Casadó-Anguera, Estefanía Moreno, Ning-Sheng Cai, Antoni Cortés, Enric I. Canela, Carmen W. Dessauer, Vicent Casadó, Leonardo Pardo, Carme Lluís, Sergi Ferré   +11 more
doaj   +1 more source

pH sensing via bicarbonate-regulated ‘soluble’ adenylyl cyclase (sAC)

Frontiers in Physiology, 2013
Soluble adenylyl cyclase (sAC) is a source of the second messenger cyclic adenosine 3',5' monophosphate (cAMP). sAC is directly regulated by bicarbonate (HCO3-) ions. In living cells, HCO3- ions are in nearly instantaneous equilibrium with carbon
Nawreen eRahman, Jochen eBuck, Lonny Ray Levin   +2 more
doaj   +1 more source

Sphingosylphosphorylcholine Antagonizes Proton-Sensing Ovarian Cancer G-Protein-Coupled Receptor 1 (OGR1)-Mediated Inositol Phosphate Production and cAMP Accumulation

Journal of Pharmacological Sciences, 2005
Ovarian cancer G-protein-coupled receptor 1 (OGR1), previously proposed as a receptor for sphingosylphosphorylcholine (SPC), has recently been identified as a proton-sensing or extracellular pH-responsive G-protein-coupled receptor stimulating inositol ...
Chihiro Mogi, Hideaki Tomura, Masayuki Tobo, Ju-Qiang Wang, Alatangaole Damirin, Junko Kon, Mayumi Komachi, Kinji Hashimoto, Koichi Sato, Fumikazu Okajima   +9 more
doaj   +1 more source

Biochemical pharmacology of adenylyl cyclases in cancer

Biochemical Pharmacology
Globally, despite extensive research and pharmacological advancement, cancer remains one of the most common causes of mortality. Understanding the signaling pathways involved in cancer progression is essential for the discovery of new drug targets. The adenylyl cyclase (AC) superfamily comprises glycoproteins that regulate intracellular signaling and ...
Jena, Bikash Chandra, Flaherty, Daniel P., O’Brien, Valerie P., Watts, Val J.   +3 more
openaire   +2 more sources

Macrophage adenylyl cyclase 7 protects against myocardial ischemia/reperfusion injury in male mice

Nature Communications
Myocardial ischemia/reperfusion (I/R) injury undermines the clinical benefit of percutaneous coronary intervention, with cardiac macrophages playing critical roles. Here, using spatial transcriptomics and flow cytometry, we identified adenylyl cyclase 7 (
Guofang Xia, Simeng Zhu, Yujia Liu, Yifan Shi, Jiaxin Chen, Jingwei Pan, Zhong Chen, Peng Wei, Chengxing Shen, Ailian Du, Congfeng Xu   +10 more
doaj   +1 more source

Lack of ANKMY2 suppresses kidney cystogenesis in embryonic- and adult-onset polycystic kidney disease.

PLoS Genetics
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive bilateral cyst formation. Multiple cellular pathways including second messenger cAMP signaling are dysregulated in ADPKD, but mechanisms initiating cysts are unknown ...
Sun-Hee Hwang, Kyungsuk Choi, Hemant Badgandi, Kevin A White, Yu Xun, Owen M Woodward, Feng Qian, Saikat Mukhopadhyay   +7 more
doaj   +1 more source

Enhanced Myocardial Adenylyl Cyclase Activity Alters Heart-Brain Communication. [PDF]

JACC Clin Electrophysiol, 2023
Agrimi J, Menicucci D, Qu JH, Laurino M, Mackey CD, Hasnain L, Tarasova YS, Tarasov KV, McDevitt RA, Hoover DB, Gemignani A, Paolocci N, Lakatta EG.   +12 more
europepmc   +1 more source

Targeting Soluble Adenylyl Cyclase for On-Demand Contraception. [PDF]

Physiology (Bethesda)
Gardner ER, Kopf GS, Buck J, Levin LR.
europepmc   +1 more source

Oligomerization of transmembrane adenylyl cyclase isoforms. [PDF]

Mol Pharmacol
Aryal S, Tesmer JJG, Dessauer CW, Watts VJ.   +3 more
europepmc   +1 more source