Results 31 to 40 of about 36,489 (201)

Fluorescent cAMP Analogs: Enzymatic Synthesis, Unexpected Photophysical Behavior and Protein Kinase A Recognition

Angewandte Chemie, EarlyView.
Cyclic adenosine monophosphate (cAMP) is a key cellular second messenger. Adenylyl cyclase converts emissive isomorphic nucleoside triphosphates into fluorescent cAMPs. cthAMP displays unusually high brightness compared to thATP, its precursor, enabling real‐time monitoring of enzymatic reactions.
Deyuan Cong, Victor Dubois, Jamie Y. Lam, Yitzhak Tor   +3 more
wiley   +2 more sources

Adenylyl cyclase Rv1625c of Mycobacterium tuberculosis: a progenitor of mammalian adenylyl cyclases [PDF]

The EMBO Journal, 2001
The gene Rv1625c from Mycobacterium tuberculosis encodes a membrane-anchored adenylyl cyclase corresponding to exactly one-half of a mammalian adenylyl cyclase. An engineered, soluble form of Rv1625c was expressed in Escherichia coli. It formed a homodimeric cyclase with two catalytic centers. Amino acid mutations predicted to affect catalysis resulted
Y L, Guo, T, Seebacher, U, Kurz, J U, Linder, J E, Schultz   +4 more
openaire   +2 more sources

Structural elucidation of the multidomain response regulator PleD using X-ray crystallography [PDF]

, 2004
c-diGMP (bis-(3!5)-cyclic di-guanosine monophosphate) is used extensively in bacteria to control biofilm formation and is lately postulated as a novel secondary messenger.
Chan, Carmen
core   +1 more source

Innate and learned odor-guided behaviors utilize distinct molecular signaling pathways in a shared dopaminergic circuit

Cell Reports, 2023
Summary: Odor-based learning and innate odor-driven behavior have been hypothesized to require separate neuronal circuitry. Contrary to this notion, innate behavior and olfactory learning were recently shown to share circuitry that includes the ...
Nathaniel C. Noyes, Ronald L. Davis
doaj   +1 more source

Further evidence supporting a role for gs signal transduction in severe malaria pathogenesis. [PDF]

, 2010
With the functional demonstration of a role in erythrocyte invasion by Plasmodium falciparum parasites, implications in the aetiology of common conditions that prevail in individuals of African origin, and a wealth of pharmacological knowledge, the ...
Jallow, Muminatou, Andrew E Fry, Angela Green, Taylor Terrie E., Haldar, Kasturi, Diakite, M, Haldar Kasturi, Kirk A Rockett, Kwiatkowski, DP, Taylor, Terrie E, Richardson, Anna, Fry, AE, Green, A, Kwiatkowski, Dominic, Sisay-Joof, Fatou, Dominic P Kwiatkowski, Kwiatkowski Dominic P., Taane G Clark, Pinder Margaret, Rockett, KA, Sisay-Joof, F, Molyneux, ME, Kasturi Haldar, Mahamadou Diakite, Sisay-Joof Fatou, Green Angela, Haldar, K, Campino, S, Auburn Sarah, Clark, Taane G, Clark, TG, Fry Andrew E., Molyneux, Malcolm E, Green, Angela, Campino Susana, Molyneux Malcolm E., Auburn, Sarah, Fatou Sisay-Joof, Pinder, M, Auburn, S, Susana Campino, Sarah Auburn, Diakite, Mahamadou, Rockett, Kirk A, Richardson, A, Muminatou Jallow, Fry, Andrew E, Richardson Anna, Jallow Muminatou, Anna Richardson, Jallow, M, Malcolm E Molyneux, Campino, Susana, Diakite Mahamadou, Rockett Kirk A., Clark Taane G., Taylor, TE, Margaret Pinder, Terrie E Taylor, Pinder, Margaret, Kwiatkowski, Dominic P   +60 more
core   +1 more source

l-DOPA-induced dyskinesia in hemiparkinsonian rats is associated with up-regulation of adenylyl cyclase type V/VI and increased GABA release in the substantia nigra reticulata

Neurobiology of Disease, 2011
l-DOPA treatment induces abnormal involuntary movements (AIMs) in Parkinson's patients and experimental animals. We examined the relationship between the development of AIMs (dyskinesia) and changes in [3H]-GABA release and cAMP signaling in ...
Claudia Rangel-Barajas, Isaac Silva, Luz María Lopéz-Santiago, Jorge Aceves, David Erlij, Benjamín Florán   +5 more
doaj   +1 more source

Inhibitors of membranous adenylyl cyclases [PDF]

Trends in Pharmacological Sciences, 2012
Membranous adenylyl cyclases (mACs) constitute a family of nine isoforms with different expression patterns. Studies with mAC gene knockout mice provide evidence for the notion that AC isoforms play distinct (patho)physiological roles. Consequently, there is substantial interest in the development of isoform-selective mAC inhibitors.
Roland, Seifert, Gerald H, Lushington, Tung-Chung, Mou, Andreas, Gille, Stephen R, Sprang   +4 more
openaire   +2 more sources

Adenylyl cyclases in the digestive system [PDF]

Cellular Signalling, 2014
Adenylyl cyclases (ACs) are a group of widely distributed enzymes whose functions are very diverse. There are nine known transmembrane AC isoforms activated by Gαs. Each has its own pattern of expression in the digestive system and differential regulation of function by Ca(2+) and other intracellular signals.
Maria Eugenia, Sabbatini, Fred, Gorelick, Shannon, Glaser   +2 more
openaire   +2 more sources

Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential

Frontiers in Physiology, 2022
In mammalian cells, 10 different adenylyl cyclases produce the ubiquitous second messenger, cyclic adenosine monophosphate (cAMP). Amongst these cAMP-generating enzymes, bicarbonate (HCO3−)-regulated soluble adenylyl cyclase (sAC; ADCY10) is uniquely ...
Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Hannes Buck, Clemens Steegborn, Robert W. Myers, Peter T. Meinke, Lonny R. Levin, Jochen Buck   +8 more
doaj   +1 more source

Rhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 Å structure of the adenylyl cyclase domain

Nature Communications, 2018
Cyclic AMP and cGMP orchestrate a variety of cellular responses. Here, authors characterize the cGMP producing rhodopsin-guanylyl cyclase from C. anguillulae and derived adenylyl cyclase by a biochemical and structural approach which demonstrates the ...
Ulrike Scheib, Matthias Broser, Oana M. Constantin, Shang Yang, Shiqiang Gao, Shatanik Mukherjee, Katja Stehfest, Georg Nagel, Christine E. Gee, Peter Hegemann   +9 more
doaj   +1 more source