Results 31 to 40 of about 33,547 (160)

Adenylyl cyclases in the digestive system [PDF]

Cellular Signalling, 2014
Adenylyl cyclases (ACs) are a group of widely distributed enzymes whose functions are very diverse. There are nine known transmembrane AC isoforms activated by Gαs. Each has its own pattern of expression in the digestive system and differential regulation of function by Ca(2+) and other intracellular signals.
Maria Eugenia, Sabbatini, Fred, Gorelick, Shannon, Glaser   +2 more
openaire   +2 more sources

Rhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 Å structure of the adenylyl cyclase domain

Nature Communications, 2018
Cyclic AMP and cGMP orchestrate a variety of cellular responses. Here, authors characterize the cGMP producing rhodopsin-guanylyl cyclase from C. anguillulae and derived adenylyl cyclase by a biochemical and structural approach which demonstrates the ...
Ulrike Scheib, Matthias Broser, Oana M. Constantin, Shang Yang, Shiqiang Gao, Shatanik Mukherjee, Katja Stehfest, Georg Nagel, Christine E. Gee, Peter Hegemann   +9 more
doaj   +1 more source

Identification of essential residues for binding and activation in the human 5-HT7(a) receptor by molecular modeling and site-directed mutagenesis

Frontiers in Behavioral Neuroscience, 2015
The human 5-HT7 receptor is expressed in both the central nervous system and peripheral tissues and is a potential drug target in behavioral and psychiatric disorders.We examined molecular determinants of ligand binding and G protein activation by the ...
Agata Antonina Rita eImpellizzeri, Agata Antonina Rita eImpellizzeri, Agata Antonina Rita eImpellizzeri, Agata Antonina Rita eImpellizzeri, Matteo ePappalardo, Matteo ePappalardo, Livia eBasile, Ornella eManfra, Ornella eManfra, Ornella eManfra, Kjetil Wessel Andressen, Kjetil Wessel Andressen, Kjetil Wessel Andressen, Kurt Allen Krobert, Kurt Allen Krobert, Kurt Allen Krobert, Angela eMessina, Angela eMessina, Finn Olav eLevy, Finn Olav eLevy, Finn Olav eLevy, Salvatore eGuccione   +21 more
doaj   +1 more source

The bZIP transcription factor Rca1p is a central regulator of a novel CO₂ sensing pathway in yeast.

PLoS Pathogens, 2012
Like many organisms the fungal pathogen Candida albicans senses changes in the environmental CO(2) concentration. This response involves two major proteins: adenylyl cyclase and carbonic anhydrase (CA).
Fabien Cottier, Martine Raymond, Oliver Kurzai, Marianne Bolstad, Worraanong Leewattanapasuk, Claudia Jiménez-López, Michael C Lorenz, Dominique Sanglard, Libuše Váchová, Norman Pavelka, Zdena Palková, Fritz A Mühlschlegel   +11 more
doaj   +1 more source

Structural basis of adenylyl cyclase 9 activation

Nature Communications, 2022
Adenylyl cyclases (ACs) generate the second messenger cAMP and play an important role in cellular signaling. Here, the authors use cryo-EM to trace the conformational changes resulting from binding to partial and full activators to one of these enzymes ...
Chao Qi, Pia Lavriha, Ved Mehta, Basavraj Khanppnavar, Inayathulla Mohammed, Yong Li, Michalis Lazaratos, Jonas V. Schaefer, Birgit Dreier, Andreas Plückthun, Ana-Nicoleta Bondar, Carmen W. Dessauer, Volodymyr M. Korkhov   +12 more
doaj   +1 more source

ADENYLYL CYCLASE ASSAYS TO MEASURE MACROPHAGE CHEMOTACTIC PROTEIN-1 RECEPTOR FUNCTION

Iranian Journal of Allergy, Asthma and Immunology, 2000
Adenylyl cyclase is a membrane-bound enzyme that catalyzes the conversion of ATP to cAMP. The inhibition of adenylyl cyclase was carried out by measuring the ability of the macrophage chemotactic protein-1 to inhibit the torskolin-induced enzyme activity.
Durdi Qujeq, Majid Ahmadi   +1 more
doaj  

Pharmacological and genetic activation of cAMP synthesis disrupts cholesterol utilization in Mycobacterium tuberculosis.

PLoS Pathogens, 2022
There is a growing appreciation for the idea that bacterial utilization of host-derived lipids, including cholesterol, supports Mycobacterium tuberculosis (Mtb) pathogenesis.
Kaley M Wilburn, Christine R Montague, Bo Qin, Ashley K Woods, Melissa S Love, Case W McNamara, Peter G Schultz, Teresa L Southard, Lu Huang, H Michael Petrassi, Brian C VanderVen   +10 more
doaj   +1 more source

Regulation of Adenylyl Cyclase by Membrane Potential [PDF]

Journal of Biological Chemistry, 1998
Mammalian adenylyl cyclases possess 12 transmembrane-spanning domains and bear a superficial resemblance to certain classes of ion channels. Some evidence suggests that bacterial and sea urchin sperm adenylyl cyclases can be regulated by membrane depolarization. In the present study, we explored the effect of altering membrane potential on the adenylyl
Cooper, Dermot M. F., Schell, Michael J., Thorn, Peter, Irvine, Robin F.   +3 more
openaire   +5 more sources

Pulmonary granulocyte influx and impaired alveolar macrophage adenylyl cyclase responsiveness in developing respiratory distress

Mediators of Inflammation, 1993
Alveolar macrophages have recently been postulated as being involved in the aetiology of adult respiratory distress syndrome (ARDS). To evaluate their role, basal cyclic AMP levels and responsiveness of adenylyl cyclase alveolar macrophages were ...
J. G. C. van Amsterdam, R. M. J. L. van der Heijde, H. P. Grotjohan, F. D. Beusenberg   +3 more
doaj   +1 more source

The role of mislocalized phototransduction in photoreceptor cell death of retinitis pigmentosa.

PLoS ONE, 2012
Most of inherited retinal diseases such as retinitis pigmentosa (RP) cause photoreceptor cell death resulting in blindness. RP is a large family of diseases in which the photoreceptor cell death can be caused by a number of pathways.
Takeshi Nakao, Motokazu Tsujikawa, Shoji Notomi, Yasuhiro Ikeda, Kohji Nishida   +4 more
doaj   +1 more source