Results 11 to 20 of about 39,778 (252)

Activation of Adenylyl Cyclase Causes Stimulation of Adenosine Receptors [PDF]

Cellular Physiology and Biochemistry, 2018
Background/Aims: Signaling of Gs protein-coupled receptors (GsPCRs) is accomplished by stimulation of adenylyl cyclase, causing an increase of the intracellular cAMP concentration, activation of the intracellular cAMP effectors protein kinase A (PKA) and
Thomas Pleli, Antonia Mondorf, Nerea Ferreiros, Dominique Thomas, Karel Dvorak, Ricardo M. Biondi, Dagmar Meyer zu Heringdorf, Stefan Zeuzem, Gerd Geisslinger, Herbert Zimmermann, Oliver Waidmann, Albrecht Piiper   +11 more
doaj   +3 more sources

Regulation of Adenylyl Cyclase by Membrane Potential [PDF]

Journal of Biological Chemistry, 1998
Mammalian adenylyl cyclases possess 12 transmembrane-spanning domains and bear a superficial resemblance to certain classes of ion channels. Some evidence suggests that bacterial and sea urchin sperm adenylyl cyclases can be regulated by membrane depolarization. In the present study, we explored the effect of altering membrane potential on the adenylyl
Cooper, Dermot M. F., Schell, Michael J., Thorn, Peter, Irvine, Robin F.   +3 more
openaire   +6 more sources

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

PTH1R Actions on Bone Using the cAMP/Protein Kinase A Pathway

Frontiers in Endocrinology, 2022
After the initial signaling action of parathyroid hormone (PTH) on bone was shown to be activation of adenylyl cyclase, its target was found to be cells of the osteoblast lineage, to the exclusion of osteoclasts and their precursors. This led to the view
T. John Martin
doaj   +1 more source

G protein-regulated endocytic trafficking of adenylyl cyclase type 9

eLife, 2020
GPCRs are increasingly recognized to initiate signaling via heterotrimeric G proteins as they move through the endocytic network, but little is known about how relevant G protein effectors are localized.
André M Lazar, Roshanak Irannejad, Tanya A Baldwin, Aparna B Sundaram, J Silvio Gutkind, Asuka Inoue, Carmen W Dessauer, Mark Von Zastrow   +7 more
doaj   +1 more source

The Effects of Different Signaling Pathways in Adenylyl Cyclase Stimulation on Red Blood Cells Deformability

Frontiers in Physiology, 2019
Signaling pathways of red blood cells’ (RBCs) micromechanics regulation, which are responsible for maintaining microcirculation, constitute an important property of RBC physiology. Selective control over these processes may serve as an indispensable tool
Alexey N. Semenov, Evgeny A. Shirshin, Evgeny A. Shirshin, Alexei V. Muravyov, Alexander V. Priezzhev, Alexander V. Priezzhev   +5 more
doaj   +1 more source

Allosteric Inhibition of Adenylyl Cyclase Type 5 by G-Protein: A Molecular Dynamics Study

Biomolecules, 2020
Adenylyl cyclases (ACs) have a crucial role in many signal transduction pathways, in particular in the intricate control of cyclic AMP (cAMP) generation from adenosine triphosphate (ATP).
Elisa Frezza, Tina-Méryl Amans, Juliette Martin   +2 more
doaj   +1 more source

CO(2) acts as a signalling molecule in populations of the fungal pathogen Candida albicans. [PDF]

, 2010
When colonising host-niches or non-animated medical devices, individual cells of the fungal pathogen Candida albicans expand into significant biomasses. Here we show that within such biomasses, fungal metabolically generated CO(2) acts as a communication
Topal Hüsnü, Maccallum, Donna M., Hall, Rebecca, Fritz A. Mühlschlegel, Gow, Neil A R, Hall, Rebecca A., Rebecca A Hall, Bloor, JW, Bloor James W., Neil A. R. Gow, Steegborn Clemens, James W, Bloor, James W., Muehlschlegel, Fritz A, Rebecca A. Hall, Buck, Jochen, Hall, RA, Wang Yue, Gow, Neil A. R., Hüsnü Topal, Hall Rebecca A., Buck Jochen, Fritz A Mühlschlegel, Eaton Rebecca, Wang, Yue, Donna M. Maccallum, Mühlschlegel Fritz A., MacCallum, Donna M, De Sordi, Luisa, Levin Lonny R., Gary K Robinson, Jochen Buck, Maccallum, DM, James W. Bloor, Steegborn, Clemens, Neil A R Gow, Topal, Husnu, Mühlschlegel, Fritz A, MacCallum Donna M., Eaton, R, De Sordi, L, Levin, LR, Gary K. Robinson, Steegborn, C, Rebecca Eaton, Luisa De Sordi, Mühlschlegel, FA, Clemens Steegborn, Robinson, GK, Lonny R Levin, Mühlschlegel, Fritz A., De Sordi Luisa, Wang, Y, Levin, Lonny R., Gow Neil A. R., Donna M Maccallum, Levin, Lonny R, Topal, Huesnue, Topal, H, Robinson, Gary K, Gow, NA, Lonny R. Levin, Eaton, Rebecca, James W Bloor, Hall, Rebecca; id_orcid, Bloor, James W, Robinson Gary K., Buck, J, Yue Wang, Robinson, Gary K.   +69 more
core   +1 more source

Identification of Novel Adenylyl Cyclase 5 (AC5) Signaling Networks in D₁ and D₂ Medium Spiny Neurons using Bimolecular Fluorescence Complementation Screening

Cells, 2019
Adenylyl cyclase type 5 (AC5), as the principal isoform expressed in striatal medium spiny neurons (MSNs), is essential for the integration of both stimulatory and inhibitory midbrain signals that initiate from dopaminergic G protein-coupled receptor ...
Trevor B. Doyle, Brian S. Muntean, Karin F. Ejendal, Michael P. Hayes, Monica Soto-Velasquez, Kirill A. Martemyanov, Carmen W. Dessauer, Chang-Deng Hu, Val J. Watts   +8 more
doaj   +1 more source

The Capacity to Secrete Insulin Is Dose-Dependent to Extremely High Glucose Concentrations: A Key Role for Adenylyl Cyclase

Metabolites, 2021
Insulin secretion is widely thought to be maximally stimulated in glucose concentrations of 16.7-to-30 mM (300-to-540 mg/dL). However, insulin secretion is seldom tested in hyperglycemia exceeding these levels despite the Guinness World Record being 147 ...
Katherine M. Gerber, Nicholas B. Whitticar, Daniel R. Rochester, Kathryn L. Corbin, William J. Koch, Craig S. Nunemaker   +5 more
doaj   +1 more source