Circulation, 2002 In the early 1960s, Earl Sutherland and his colleagues performed a series of experiments that led to the understanding that the positive inotropic effects of β-adrenergic agonists were mediated by the activation of the enzyme adenylyl cyclase (AC) and the subsequent production of cyclic adenosine monophosphate (cAMP).1 By measuring tissue cAMP levels ...
Arthur Feldman
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Adenylyl Cyclase Rv1625c of Mycobacterium tuberculosis: A Progenitor of Mammalian Adenylyl Cyclases [PDF]
EMBO Journal, 2001 The gene Rv1625c from Mycobacterium tuberculosis encodes a membrane-anchored adenylyl cyclase corresponding to exactly one-half of a mammalian adenylyl cyclase. An engineered, soluble form of Rv1625c was expressed in Escherichia coli. It formed a homodimeric cyclase with two catalytic centers. Amino acid mutations predicted to affect catalysis resulted
Joachim E Schultz, Jürgen U Linder
exaly +3 more sources
Structural insights into signal transduction in photoactivated adenylyl cyclase through molecular dynamics simulations [PDF]
Protein Science, Volume 35, Issue 12, December 2026.Abstract OaPAC, from Oscillatoria acuminata, is a homodimer protein consisting of the blue‐light using flavin domain and the adenylyl cyclase (AC) domain, linked by long coiled‐coil α3‐helices. Upon blue‐light absorption, a rearrangement of the hydrogen‐bonding network involving the flavin chromophore, Y6, and Q48 triggers signal propagation through ...
Akiya Fukuda +5 more
wiley +2 more sources
Macrophage adenylyl cyclase 7 protects against myocardial ischemia/reperfusion injury in male mice [PDF]
Nature CommunicationsMyocardial ischemia/reperfusion (I/R) injury undermines the clinical benefit of percutaneous coronary intervention, with cardiac macrophages playing critical roles. Here, using spatial transcriptomics and flow cytometry, we identified adenylyl cyclase 7 (
Guofang Xia +10 more
doaj +2 more sources
Adenylyl Cyclase 9: A Maverick Signalling Act in Search of Plots [PDF]
CellsCryo-electronmicroscopy has revolutionized the study of integral membrane proteins. In the case of adenylyl cyclase 9 (AC9)—one of nine transmembrane paralogues in mammals that produce the ubiquitous intracellular messenger cyclic AMP—the technique was ...
Ferenc A. Antoni
doaj +2 more sources
Editorial: Adenylyl cyclase isoforms as potential drug targets [PDF]
Frontiers in Pharmacology, 2022 Editorial on the Research Topic Adenylyl cyclase isoforms as potential drug ...
Tarsis F. Brust +3 more
doaj +2 more sources
Gαs, adenylyl cyclase, and their relationship to the diagnosis and treatment of depression
Frontiers in Pharmacology, 2022 The relationship between depression, its etiology and therapy, and the cAMP signaling system have been studies for decades. This review will focus on cAMP, G proteins and adenylyl cyclase and depression or antidepressant action.
Jeffrey M. Schappi +5 more
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Strategies to safely target widely expressed soluble adenylyl cyclase for contraception
Frontiers in Pharmacology, 2022 In humans, the prototypical second messenger cyclic AMP is produced by 10 adenylyl cyclase isoforms, which are divided into two classes. Nine isoforms are G protein coupled transmembrane adenylyl cyclases (tmACs; ADCY1-9) and the 10th is the bicarbonate ...
Jacob Ferreira +2 more
doaj +1 more source
The YHS-Domain of an Adenylyl Cyclase from Mycobacterium phlei Is a Probable Copper-Sensor Module. [PDF]
PLoS ONE, 2015 YHS-domains are small protein modules which have been proposed to bind transition-metal ions like the related TRASH-domains. They are found in a variety of enzymes including copper-transporting ATPases and adenylyl cyclases.
Jürgen Ulrich Linder
doaj +1 more source
Role of adenylyl cyclase in reduced β-adrenoceptor-mediated vasorelaxation during maturation [PDF]
Brazilian Journal of Medical and Biological Research, 2016 Beta-adrenergic receptor (βAR)-dependent blood vessel relaxation is impaired in older animals and G protein activation has been suggested as the causative mechanism.
O.A. López-Canales +5 more
doaj +4 more sources