Results 21 to 30 of about 39,778 (252)
Neuromodulation: Technology at the Neural Interface, EarlyView., 2021 Abstract Objectives Acute cerebral ischemia is characterized by several pathological processes evolving during time, which contribute to the final tissue damage. Secondary processes, such as prolonged inflammatory response, impaired mitochondrial function and oxidative stress, are responsible for the progression of brain injury to the peri‐infarct area,
Fioravante Capone +8 more
wiley +1 more source
BMC Cell Biology, 2004 Background We investigated how the synthesis of cAMP, stimulated by isoproterenol acting through β-adrenoreceptors and Gs, is strongly amplified by simultaneous incubation with baclofen.
Robichon Alain +3 more
doaj +1 more source
Frontiers in Endocrinology, 2022 Despite great efforts, effective treatment against cancer has not yet been found. However, natural compounds such as the polyphenol resveratrol have emerged as promising preventive agent in cancer therapy.
Sonia Muñoz-López +3 more
doaj +1 more source
Circulation, 2002 In the early 1960s, Earl Sutherland and his colleagues performed a series of experiments that led to the understanding that the positive inotropic effects of β-adrenergic agonists were mediated by the activation of the enzyme adenylyl cyclase (AC) and the subsequent production of cyclic adenosine monophosphate (cAMP).1 By measuring tissue cAMP levels ...
openaire +1 more source
A molecular dynamics study of adenylyl cyclase: The impact of ATP and G-protein binding. [PDF]
PLoS ONE, 2018 Adenylyl cyclases (ACs) catalyze the biosynthesis of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP) and play an important role in many signal transduction pathways.
Elisa Frezza +2 more
doaj +1 more source
Editorial: Adenylyl cyclase isoforms as potential drug targets
Frontiers in Pharmacology, 2022 Editorial on the Research Topic Adenylyl cyclase isoforms as potential drug ...
Tarsis F. Brust +3 more
doaj +3 more sources
Controlling fertilization and cAMP signaling in sperm by optogenetics
eLife, 2015 Optogenetics is a powerful technique to control cellular activity by light. The light-gated Channelrhodopsin has been widely used to study and manipulate neuronal activity in vivo, whereas optogenetic control of second messengers in vivo has not been ...
Vera Jansen +6 more
doaj +1 more source
Sympathetic Neurotransmitters Modulate Osteoclastogenesis and Osteoclast Activity in the Context of Collagen-Induced Arthritis. [PDF]
PLoS ONE, 2015 Excessive synovial osteoclastogenesis is a hallmark of rheumatoid arthritis (RA). Concomitantly, local synovial changes comprise neuronal components of the peripheral sympathetic nervous system.
Dominique Muschter +4 more
doaj +1 more source
Cyclic nucleotide binding and structural changes in the isolated GAF domain of Anabaena adenylyl cyclase, CyaB2 [PDF]
PeerJ, 2015 GAF domains are a large family of regulatory domains, and a subset are found associated with enzymes involved in cyclic nucleotide (cNMP) metabolism such as adenylyl cyclases and phosphodiesterases.
Kabir Hassan Biswas +4 more
doaj +2 more sources
Structural elucidation of the multidomain response regulator PleD using X-ray crystallography [PDF]
, 2004 c-diGMP (bis-(3!5)-cyclic di-guanosine monophosphate) is used extensively in bacteria to control biofilm formation and is lately postulated as a novel secondary messenger.
Chan, Carmen
core +1 more source