Results 21 to 30 of about 36,489 (201)

The Capacity to Secrete Insulin Is Dose-Dependent to Extremely High Glucose Concentrations: A Key Role for Adenylyl Cyclase

Metabolites, 2021
Insulin secretion is widely thought to be maximally stimulated in glucose concentrations of 16.7-to-30 mM (300-to-540 mg/dL). However, insulin secretion is seldom tested in hyperglycemia exceeding these levels despite the Guinness World Record being 147 ...
Katherine M. Gerber, Nicholas B. Whitticar, Daniel R. Rochester, Kathryn L. Corbin, William J. Koch, Craig S. Nunemaker   +5 more
doaj   +1 more source

CO(2) acts as a signalling molecule in populations of the fungal pathogen Candida albicans. [PDF]

, 2010
When colonising host-niches or non-animated medical devices, individual cells of the fungal pathogen Candida albicans expand into significant biomasses. Here we show that within such biomasses, fungal metabolically generated CO(2) acts as a communication
Topal Hüsnü, Maccallum, Donna M., Hall, Rebecca, Fritz A. Mühlschlegel, Gow, Neil A R, Hall, Rebecca A., Rebecca A Hall, Bloor, JW, Bloor James W., Neil A. R. Gow, Steegborn Clemens, James W, Bloor, James W., Muehlschlegel, Fritz A, Rebecca A. Hall, Buck, Jochen, Hall, RA, Wang Yue, Gow, Neil A. R., Hüsnü Topal, Hall Rebecca A., Buck Jochen, Fritz A Mühlschlegel, Eaton Rebecca, Wang, Yue, Donna M. Maccallum, Mühlschlegel Fritz A., MacCallum, Donna M, De Sordi, Luisa, Levin Lonny R., Gary K Robinson, Jochen Buck, Maccallum, DM, James W. Bloor, Steegborn, Clemens, Neil A R Gow, Topal, Husnu, Mühlschlegel, Fritz A, MacCallum Donna M., Eaton, R, De Sordi, L, Levin, LR, Gary K. Robinson, Steegborn, C, Rebecca Eaton, Luisa De Sordi, Mühlschlegel, FA, Clemens Steegborn, Robinson, GK, Lonny R Levin, Mühlschlegel, Fritz A., De Sordi Luisa, Wang, Y, Levin, Lonny R., Gow Neil A. R., Donna M Maccallum, Levin, Lonny R, Topal, Huesnue, Topal, H, Robinson, Gary K, Gow, NA, Lonny R. Levin, Eaton, Rebecca, James W Bloor, Hall, Rebecca; id_orcid, Bloor, James W, Robinson Gary K., Buck, J, Yue Wang, Robinson, Gary K.   +69 more
core   +1 more source

Simultaneous stimulation of GABA and beta adrenergic receptors stabilizes isotypes of activated adenylyl cyclase heterocomplex

BMC Cell Biology, 2004
Background We investigated how the synthesis of cAMP, stimulated by isoproterenol acting through β-adrenoreceptors and Gs, is strongly amplified by simultaneous incubation with baclofen.
Robichon Alain, Tinette Sylvette, Courtial Cédric, Pelletier Franck   +3 more
doaj   +1 more source

A molecular dynamics study of adenylyl cyclase: The impact of ATP and G-protein binding. [PDF]

PLoS ONE, 2018
Adenylyl cyclases (ACs) catalyze the biosynthesis of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP) and play an important role in many signal transduction pathways.
Elisa Frezza, Juliette Martin, Richard Lavery   +2 more
doaj   +1 more source

Resveratrol enhances A1 and hinders A2A adenosine receptors signaling in both HeLa and SH-SY5Y cells: Potential mechanism of its antitumoral action

Frontiers in Endocrinology, 2022
Despite great efforts, effective treatment against cancer has not yet been found. However, natural compounds such as the polyphenol resveratrol have emerged as promising preventive agent in cancer therapy.
Sonia Muñoz-López, Alejandro Sánchez-Melgar, Mairena Martín, José Luis Albasanz   +3 more
doaj   +1 more source

The adenylyl cyclase gene from Schizosaccharomyces pombe [PDF]

, 1989
We cloned the adenylyl cyclase gene from the fission yeast Schizosaccharomyces pombe using low-stringency hybridization to the Saccharomyces cerevisiae adenylyl cyclase gene. The Sc. pombe gene encodes a 1692-amino acid-residue protein.
Wigler, M. H., Vojtek, A., Broek, D., Young, D., Riggs, M., Field, J.   +5 more
core   +1 more source

Controlling fertilization and cAMP signaling in sperm by optogenetics

eLife, 2015
Optogenetics is a powerful technique to control cellular activity by light. The light-gated Channelrhodopsin has been widely used to study and manipulate neuronal activity in vivo, whereas optogenetic control of second messengers in vivo has not been ...
Vera Jansen, Luis Alvarez, Melanie Balbach, Timo Strünker, Peter Hegemann, U Benjamin Kaupp, Dagmar Wachten   +6 more
doaj   +1 more source

Sympathetic Neurotransmitters Modulate Osteoclastogenesis and Osteoclast Activity in the Context of Collagen-Induced Arthritis. [PDF]

PLoS ONE, 2015
Excessive synovial osteoclastogenesis is a hallmark of rheumatoid arthritis (RA). Concomitantly, local synovial changes comprise neuronal components of the peripheral sympathetic nervous system.
Dominique Muschter, Nicole Schäfer, Hubert Stangl, Rainer H Straub, Susanne Grässel   +4 more
doaj   +1 more source

Adenylyl Cyclase [PDF]

Circulation, 2002
In the early 1960s, Earl Sutherland and his colleagues performed a series of experiments that led to the understanding that the positive inotropic effects of β-adrenergic agonists were mediated by the activation of the enzyme adenylyl cyclase (AC) and the subsequent production of cyclic adenosine monophosphate (cAMP).1 By measuring tissue cAMP levels ...
openaire   +1 more source

Cyclic nucleotide binding and structural changes in the isolated GAF domain of Anabaena adenylyl cyclase, CyaB2 [PDF]

PeerJ, 2015
GAF domains are a large family of regulatory domains, and a subset are found associated with enzymes involved in cyclic nucleotide (cNMP) metabolism such as adenylyl cyclases and phosphodiesterases.
Kabir Hassan Biswas, Suguna Badireddy, Abinaya Rajendran, Ganesh Srinivasan Anand, Sandhya S. Visweswariah   +4 more
doaj   +2 more sources