Results 41 to 50 of about 39,778 (252)

An investigation of the response of a model class IIIA Adenyly Cyclase to carbon dioxide [PDF]

, 2009
Adenylyl cyclase catalyses the conversion of adenosine triphosphate into 3’,5'-cyclic adenosine monophosphate and pyrophosphate. Adenylyl cyclases are grouped into six distinct Classes based on amino acid sequence similarity.
Holliday, Phillip
core  

Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity

Advanced Science, EarlyView.
Myoglobin, known as a muscle oxygen‐carrying protein, is shown to play a key role in fat cells that burn energy. Loss of myoglobin reduces the body's ability to generate heat and increases obesity risk, while restoring it improves metabolism. The study identifies myoglobin as a regulator of fat burning and a potential target to enhance energy ...
Christian Strehlau, Helen Broghammer, Claudia Gebhardt, Anne Hoffmann, Tobias Hagemann, Şeyma Midilli, Rachel S. Zimmer, Kristin Schubert, Vasiliki Karagiannakou, Anastasia Georgiadi, Mario Ost, Martin Krüger, Lisa Roth, Kerstin Krause, Nora Klöting, Maria Keller, Martin Wabitsch, Rima Nuwayhid, Roland H. Stimson, Michael Stumvoll, Matthias Blüher, Juliane Weiner, John T. Heiker   +22 more
wiley   +1 more source

Further evidence supporting a role for gs signal transduction in severe malaria pathogenesis. [PDF]

, 2010
With the functional demonstration of a role in erythrocyte invasion by Plasmodium falciparum parasites, implications in the aetiology of common conditions that prevail in individuals of African origin, and a wealth of pharmacological knowledge, the ...
Jallow, Muminatou, Andrew E Fry, Angela Green, Taylor Terrie E., Haldar, Kasturi, Diakite, M, Haldar Kasturi, Kirk A Rockett, Kwiatkowski, DP, Taylor, Terrie E, Richardson, Anna, Fry, AE, Green, A, Kwiatkowski, Dominic, Sisay-Joof, Fatou, Dominic P Kwiatkowski, Kwiatkowski Dominic P., Taane G Clark, Pinder Margaret, Rockett, KA, Sisay-Joof, F, Molyneux, ME, Kasturi Haldar, Mahamadou Diakite, Sisay-Joof Fatou, Green Angela, Haldar, K, Campino, S, Auburn Sarah, Clark, Taane G, Clark, TG, Fry Andrew E., Molyneux, Malcolm E, Green, Angela, Campino Susana, Molyneux Malcolm E., Auburn, Sarah, Fatou Sisay-Joof, Pinder, M, Auburn, S, Susana Campino, Sarah Auburn, Diakite, Mahamadou, Rockett, Kirk A, Richardson, A, Muminatou Jallow, Fry, Andrew E, Richardson Anna, Jallow Muminatou, Anna Richardson, Jallow, M, Malcolm E Molyneux, Campino, Susana, Diakite Mahamadou, Rockett Kirk A., Clark Taane G., Taylor, TE, Margaret Pinder, Terrie E Taylor, Pinder, Margaret, Kwiatkowski, Dominic P   +60 more
core   +1 more source

The bZIP transcription factor Rca1p is a central regulator of a novel CO₂ sensing pathway in yeast.

PLoS Pathogens, 2012
Like many organisms the fungal pathogen Candida albicans senses changes in the environmental CO(2) concentration. This response involves two major proteins: adenylyl cyclase and carbonic anhydrase (CA).
Fabien Cottier, Martine Raymond, Oliver Kurzai, Marianne Bolstad, Worraanong Leewattanapasuk, Claudia Jiménez-López, Michael C Lorenz, Dominique Sanglard, Libuše Váchová, Norman Pavelka, Zdena Palková, Fritz A Mühlschlegel   +11 more
doaj   +1 more source

Structural basis of adenylyl cyclase 9 activation

Nature Communications, 2022
Adenylyl cyclases (ACs) generate the second messenger cAMP and play an important role in cellular signaling. Here, the authors use cryo-EM to trace the conformational changes resulting from binding to partial and full activators to one of these enzymes ...
Chao Qi, Pia Lavriha, Ved Mehta, Basavraj Khanppnavar, Inayathulla Mohammed, Yong Li, Michalis Lazaratos, Jonas V. Schaefer, Birgit Dreier, Andreas Plückthun, Ana-Nicoleta Bondar, Carmen W. Dessauer, Volodymyr M. Korkhov   +12 more
doaj   +1 more source

THE IDENTIFICATION OF NOVEL INORGANIC CARBON SENSITIVE ENZYMES [PDF]

, 2010
Adenylyl cyclase catalyses the formation of the second messenger adenosine-3’, 5’-monophosphate from adenosine triphosphate, and is involved in a number of diverse signalling pathways in eukaryotes and prokaryotes.
TOWNSEND, PHILIP,DAVID, Townsend, Philip David   +1 more
core  

The adenylyl cyclase gene from Schizosaccharomyces pombe

, 1989
We cloned the adenylyl cyclase gene from the fission yeast Schizosaccharomyces pombe using low-stringency hybridization to the Saccharomyces cerevisiae adenylyl cyclase gene. The Sc. pombe gene encodes a 1692-amino acid-residue protein.
Wigler, M. H., Vojtek, A., Broek, D., Young, D., Riggs, M., Field, J.   +5 more
core   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Requirement of Drosophila NF1 for activation of adenylyl cyclase by PACAP38-like neuropeptides

, 1997
The human neurofibromatosis type 1 (NF1) tumor suppressor protein functions as a Ras-specific guanosine triphosphatase-activating protein, but the identity of Ras- mediated pathways modulated by NF1 remains unknown.
Hui-fu Guo, Inge The, Frances Hannan, Hannan, F., Bernards, A., Zhong, Y., Guo, H. F., Yi Zhong, The, I., Andre ́ Bernards   +9 more
core   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source