Results 41 to 50 of about 36,489 (201)

An investigation of the response of a model class IIIA Adenyly Cyclase to carbon dioxide [PDF]

, 2009
Adenylyl cyclase catalyses the conversion of adenosine triphosphate into 3’,5'-cyclic adenosine monophosphate and pyrophosphate. Adenylyl cyclases are grouped into six distinct Classes based on amino acid sequence similarity.
Holliday, Phillip
core  

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Identification of essential residues for binding and activation in the human 5-HT7(a) receptor by molecular modeling and site-directed mutagenesis

Frontiers in Behavioral Neuroscience, 2015
The human 5-HT7 receptor is expressed in both the central nervous system and peripheral tissues and is a potential drug target in behavioral and psychiatric disorders.We examined molecular determinants of ligand binding and G protein activation by the ...
Agata Antonina Rita eImpellizzeri, Agata Antonina Rita eImpellizzeri, Agata Antonina Rita eImpellizzeri, Agata Antonina Rita eImpellizzeri, Matteo ePappalardo, Matteo ePappalardo, Livia eBasile, Ornella eManfra, Ornella eManfra, Ornella eManfra, Kjetil Wessel Andressen, Kjetil Wessel Andressen, Kjetil Wessel Andressen, Kurt Allen Krobert, Kurt Allen Krobert, Kurt Allen Krobert, Angela eMessina, Angela eMessina, Finn Olav eLevy, Finn Olav eLevy, Finn Olav eLevy, Salvatore eGuccione   +21 more
doaj   +1 more source

GTPγS Regulation of a 12-Transmembrane Guanylyl Cyclase Is Retained after Mutation to an Adenylyl Cyclase [PDF]

, 2001
DdGCA is a Dictyostelium guanylyl cyclase with a topology typical for mammalian adenylyl cyclases containing 12 transmembrane-spanning regions and two cyclase domain.
Haastert, Peter J.M. van,, Van Haastert, PJM, Roelofs, J, Loovers, Harriet, Loovers, Harriët M.,, Roelofs, Jeroen,   +5 more
core   +2 more sources

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

The bZIP transcription factor Rca1p is a central regulator of a novel CO₂ sensing pathway in yeast.

PLoS Pathogens, 2012
Like many organisms the fungal pathogen Candida albicans senses changes in the environmental CO(2) concentration. This response involves two major proteins: adenylyl cyclase and carbonic anhydrase (CA).
Fabien Cottier, Martine Raymond, Oliver Kurzai, Marianne Bolstad, Worraanong Leewattanapasuk, Claudia Jiménez-López, Michael C Lorenz, Dominique Sanglard, Libuše Váchová, Norman Pavelka, Zdena Palková, Fritz A Mühlschlegel   +11 more
doaj   +1 more source

Structural basis of adenylyl cyclase 9 activation

Nature Communications, 2022
Adenylyl cyclases (ACs) generate the second messenger cAMP and play an important role in cellular signaling. Here, the authors use cryo-EM to trace the conformational changes resulting from binding to partial and full activators to one of these enzymes ...
Chao Qi, Pia Lavriha, Ved Mehta, Basavraj Khanppnavar, Inayathulla Mohammed, Yong Li, Michalis Lazaratos, Jonas V. Schaefer, Birgit Dreier, Andreas Plückthun, Ana-Nicoleta Bondar, Carmen W. Dessauer, Volodymyr M. Korkhov   +12 more
doaj   +1 more source

THE IDENTIFICATION OF NOVEL INORGANIC CARBON SENSITIVE ENZYMES [PDF]

, 2010
Adenylyl cyclase catalyses the formation of the second messenger adenosine-3’, 5’-monophosphate from adenosine triphosphate, and is involved in a number of diverse signalling pathways in eukaryotes and prokaryotes.
TOWNSEND, PHILIP,DAVID, Townsend, Philip David   +1 more
core  

Gαi1/3 Are Essential for BMP2‐Induced Osteogenesis by Bridging BMP Receptors to the Gab1 Signaling Complex

Advanced Science, EarlyView.
The Gαi1/3 protein is a crucial connecting protein closely related to the signal transduction process of bone formation‐related cytokines such as BMP2. Gαi1/3 mediates downstream signaling pathways such as Smads and MAPK by binding to adaptor proteins like Gab1, thereby promoting the osteogenic effect of BMSCs.
Huajian Shan, Chaowen Bai, Yifei Zhu, Chenyang Xu, Sonngtao Li, Qize Sun, Chang She, Jinyu Bai, Cong Cao, Yitian Yang, Xiaozhong Zhou   +10 more
wiley   +1 more source

No evidence for oncogenic mutations in guanine nucleotide-binding proteins of human adrenocortical neoplasms [PDF]

, 1933
G-Proteins are membrane-bound heterotrimeric polypeptides that couple receptor signals to second messenger systems such as cAMP. Recently, point mutations at 2 codons of the highly preserved alpha-chain of Gs, the adenyl cyclase-stimulating G-protein ...
Travis, W., Karl, M., Chrousos, G. P., Reincke, Martin   +3 more
core   +1 more source