Results 61 to 70 of about 39,778 (252)
Ca2+ inhibition of type III adenylyl cyclase in vivo
, 1995 Type III adenylyl cyclase is stimulated by beta-adrenergic agonists and glucagon in vitro and in vivo, but not by Ca2+ and calmodulin. However, the enzyme is stimulated by Ca2+ and calmodulin in vitro when it is concomitantly activated by the guanyl ...
Wayman, G A, Storm, D R, Impey, S
core +1 more source
The role of mislocalized phototransduction in photoreceptor cell death of retinitis pigmentosa.
PLoS ONE, 2012 Most of inherited retinal diseases such as retinitis pigmentosa (RP) cause photoreceptor cell death resulting in blindness. RP is a large family of diseases in which the photoreceptor cell death can be caused by a number of pathways.
Takeshi Nakao +4 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Opioid tolerance, opioid-induced hyperalgesia during repeated opioid administration, and chronic pain are associated with upregulation of adenylyl cyclase activity.
Kayla Johnson +8 more
doaj +1 more source
The potential for biased signalling in the P2Y receptor family of GPCRs
British Journal of Pharmacology, EarlyView.The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk +2 more
wiley +1 more source
Cell signalling in Paracoccidioides Brasiliensis [PDF]
, 2006 Paracocidioides brasiliensis (P. brasiliensis or Pb) is the etiological agent of paracocidioidomycosis which is the most prevalent systemic mycosis in South America.
Chen, Daliang
core
Effects of chlorogenic acid on carbachol-induced contraction of mouse urinary bladder
Journal of Pharmacological Sciences, 2018 Chlorogenic acid (CGA) is a polyphenol found in coffee and medicinal herbs such as Lonicera japonica. In this study, the effect of CGA-induced relaxation on carbachol (CCh)-induced contraction of mouse urinary bladder was investigated. CGA (30–300 μg/ml)
Takeharu Kaneda +3 more
doaj +1 more source
PDE4D and PDE3B orchestrate distinct cAMP microdomains in 3T3‐L1 adipocytes
British Journal of Pharmacology, EarlyView.Basal conditions: •Ins/PDE3B lowers cytoplasmic cAMP (cyt‐cAMP) without affecting plasma membrane cAMP (pm‐cAMP). •Insulin decreases lipid droplet cAMP (LD‐cAMP) independent of PDE3B. •FGF1/PDE4D modestly reduces both cyt‐ and pm‐cAMP, while PDE4D alone can modulate LD‐cAMP. ISO stimulation: •Ins/PDE3B has minimal impact on cyt‐cAMP.
Johannes Krier +9 more
wiley +1 more source
Effets d'un traitement chronique par la morphine sur le protéome des cellules de neuroblastome humain SH-SY5Y [PDF]
, 2007 Afin de mieux comprendre les adaptations cellulaires induites suite à une prise chronique de morphine, une stratégie de type protéomique différentielle combinant les techniques d'électrophorèse et de spectrométrie de masse a été entreprise dans des ...
Mouledous, Lionel
core
Adenylyl cyclase signalling complexes - pharmacological challenges and opportunities [PDF]
, 2017 Signalling pathways involving the vital second messanger, cAMP, impact on most significant physiological processes. Unsurprisingly therefore, the activation and regulation of cAMP signalling is tightly controlled within the cell by processes including ...
Halls, Michelle L, Cooper, Dermot M F
core +1 more source
Stimulatory effects of adenosine on prolactin secretion in the pituitary gland of the rat
Brazilian Journal of Medical and Biological Research, 2002 We investigated the effects of adenosine on prolactin (PRL) secretion from rat anterior pituitaries incubated in vitro. The administration of 5-N-methylcarboxamidoadenosine (MECA), an analog agonist that preferentially activates A2 receptors, induced a ...
D.L.W. Picanço-Diniz +3 more
doaj +1 more source