Results 81 to 90 of about 39,778 (252)

The adenylyl cyclase signaling system in normal and failing myocardium [PDF]

, 2014
This bachelor thesis describes a signal pathway of adenylyl cyclase, which plays a key role in the modulation of heart rate and force of contraction.
Karlovská, Ivana
core  

Molecular cloning of the human type VIII adenylyl cyclase

, 1994
A cDNA coding for a human type VIII adenylyl cyclase has been isolated from human newborn brain-stem tissue. This cDNA is 6,005 bp long and encodes for a protein of 1251 amino acids, exhibiting the two sets of six transmembrane spanning regions and the ...
Alena Danisova, Hanoune, Jacques, Defer, Nicole, Matsuoka, Isao, Isao Matsuoka, Jacques Hanoune, Marinx, Olivier, Dominique Stengel, Caput, Daniel, Nicole Defer, Olivier Marinx, Vadim Iourgenko, Daniel Caput, Danisova, Alena, Stengel, Dominique, Iourgenko, Vadim   +15 more
core   +1 more source

The Dictyostelium homologue of mammalian soluble adenylyl cyclase encodes a guanylyl cyclase [PDF]

, 2001
A new Dictyostelium discoideum cyclase gene was identified that encodes a protein (sGC) with 35% similarity to mammalian soluble adenylyl cyclase (sAC). Gene disruption of sGC has no effect on adenylyl cyclase activity and results in a >10-fold reduction
Haastert, Peter J.M. van,, Schaap, Pauline,, Van Haastert, PJM, Roelofs, J, Schaap, P, Meima, Marcel,, Meima, M, Roelofs, Jeroen,   +7 more
core   +1 more source

Bicarbonate Stimulated Adenylyl Cyclases [PDF]

IUBMB Life, 2004
AbstractBicarbonate ion is fundamental to the biology of all living organisms. HCO3‐ is vital to such diverse physiological processes as carbon fixation, cellular homeostasis, sperm maturation, and nucleotide synthesis. A defined subset of adenylyl cyclases identified in eukaryotes and prokaryotes are directly activated by HCO3‐.
openaire   +2 more sources

Atrial natriuretic peptide counteracts aldosterone secretion by preventing acute angiotensin II‐induced cAMP signalling

British Journal of Pharmacology, EarlyView.
Background and Purpose Aldosterone plays a key role in blood pressure and volume regulation. Enhanced aldosterone secretion contributes to cardiovascular and renal diseases. Therefore, inhibitors of aldosterone receptors and synthase are essential drugs for the treatment of hypertension and heart failure.
Sanika Mohagaonkar, Egor B. Skryabin, Bettina M. Buchholz, Michaela Kuhn, Celso E. Gomez‐Sanchez, Stepan Gambaryan, Viacheslav O. Nikolaev   +6 more
wiley   +1 more source

Isoform-dependent activation of adenylyl cyclase by proteolysis

, 1997
Recent findings have suggested that the cellular proteolytic system plays a major role in the regulation of various intra- and extra-cellular signaling.
Jun-ichi Kawabe, Naoki Oka, Toya, Yoshiyuki, Yoshihiro Ishikawa, Ebina, Toshiaki, Carsten Schwencke, Kawabe, Jun-ichi, Oka, Naoki, Schwencke, Carsten, Ishikawa, Yoshihiro, Toshiaki Ebina, Yoshiyuki Toya   +11 more
core   +1 more source

Endothelium‐ and epithelium‐derived novel endogenous catecholamines as modulators of the autonomic nervous system

British Journal of Pharmacology, EarlyView.
Abstract Catecholamines are classically viewed as neuronal transmitters and adrenal hormones; however, accumulating evidence demonstrates that sources other than nerve fibres and adrenal medulla play a fundamental role in local organ regulation. Physiological paradoxes, such as preserved organ function after denervation or transplantation, challenge a ...
Mariana G. de Oliveira, Edson Antunes, Fabiola Zakia Monica, Gilberto De Nucci   +3 more
wiley   +1 more source

Agonist‐specific conformational dynamics at the β2‐adrenoceptor dictate allosteric modulation of Gαs signalling and bronchodilation

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose β2‐adrenoceptor (β2AR) agonists are the cornerstone of asthma therapy and promote bronchodilation through Gαs signalling in airway smooth muscle (ASM), but their efficacy is limited by β‐arrestin‐mediated β2AR desensitization.
Sushrut D. Shah, Joshua Richard, Suvankar Ghosh, Jillian Jerwick, Joice T. Gavali, Raymond B. Penn, Alexander D. MacKerell Jr, Deepak A. Deshpande   +7 more
wiley   +1 more source

Dop1 enhances conspecific olfactory attraction by inhibiting miR-9a maturation in locusts

Nature Communications, 2018
Migratory locusts shift between aggregating together during gregarious phases and living individually during solitary phases. Here, the authors find that the D1-like dopamine receptor regulates the olfactory attraction underlying this behavioral switch ...
Xiaojiao Guo, Zongyuan Ma, Baozhen Du, Ting Li, Wudi Li, Lingling Xu, Jing He, Le Kang   +7 more
doaj   +1 more source

Dose–Response Effect of Glucagon on Glucose, Beta‐Cell Secretion and Metabolism in Healthy Individuals

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim Glucagon is a key regulator of glucose and energy metabolism, yet the dose–response effects of glucagon on markers of metabolism in humans are not fully characterised. We investigated the dose‐dependent effects of glucagon on glucose metabolism, β‐cell secretion and markers of hepatic metabolism in healthy adults.
Sophie Betty Brock, Nina Lerberg Hansen, Elvar Már Sturlaugsson Jóhönnuson, Sasha Alexandra Sampson Kjeldsen, Nicolai J. Wewer Albrechtsen   +4 more
wiley   +1 more source