Results 41 to 50 of about 197,372 (218)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

國民中學適足教育經費:臺灣偏遠與非偏遠地區學校的比較 Estimating Adequate Funding to Meet Performance Standards for Junior High School Students: Adequate Funding Comparisons Between Rural and Non-Rural Schools in Taiwan

open access: yesJournal of Research in Education Sciences, 2016
臺灣學生近年來在國際大型測驗表現亮眼,但如進一步檢視學校所處地區,即可明顯看出臺灣存在巨大的城鄉差距問題:偏遠地區與大城市相比,不僅數學表現較差,且出現各校數學差距相對較大的情況。不足的教育經費可能是導致此差距的原因之一,本研究因此以成本函數法來估算偏遠與非偏遠地區學校達成預期學生學業成就所需的適足經費,並以國中基測數學基礎級、平均數、精熟級來作為適足分數,以估算不同程度所需的適足經費,結果發現,無論何種適足分數,偏遠地區所需的每生適足經費皆比非偏遠地區為高,且超過半數以上的偏遠學校未達適足經費水準 ...
張良丞 Liang-Cheng Zhang   +2 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

open access: yesFEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata   +13 more
wiley   +1 more source

Estado nutricional e adequação da ingestão de energia e nutrientes em pacientes com insuficiência cardíaca Estado nutricional y adecuación de la ingesta de energía y nutrientes en pacientes con insuficiencia cardiaca Nutritional status and adequacy of energy and nutrient intakes among heart failure patients

open access: yesArquivos Brasileiros de Cardiologia, 2009
FUNDAMENTO: Maior conhecimento sobre o estado nutricional e a ingestão de energia e nutrientes é necessário para auxiliar no tratamento de pacientes com insuficiência cardíaca (IC).
Bárbara Hatzlhoffer Lourenço   +5 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

open access: yesFEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão   +3 more
wiley   +1 more source

The meaning of „adequate” under GDPR – lesson learnt from EU bodies

open access: yesEastern European Journal of Transnational Relations
The concept of “adequate” data protection model in third country or organisation plays vital role in General Data Protection Regulation, but more importantly – in business and relations between European Union and other international actors ...
Dominika Kuźnicka-Błaszkowska
doaj   +1 more source

NETWORK TRAFFIC FORCASTING IN INFORMATION-TELECOMMUNICATION SYSTEM OF PRYDNIPROVSK RAILWAYS BASED ON NEURO-FUZZY NETWORK

open access: yesNauka ta progres transportu, 2016
Purpose. Continuous increase in network traffic in the information-telecommunication system (ITS) of Prydniprovsk Railways leads to the need to determine the real-time network congestion and to control the data flows.
V. M. Pakhomovа
doaj   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

open access: yesFEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar   +11 more
wiley   +1 more source

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