Results 61 to 70 of about 185,911 (262)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Variability of terms in translation studies: problems of term use and analysis of translation decisions (an experimental and methodological study)

Вісник Харківського національного університету імені В. Н. Каразіна. Серія Іноземна філологія. Методика викладання іноземних мов
The article deals with the terminological variability in translation studies as a factor influencing the research methodology and practical translation analysis in students’ scientific and qualification works.
Marharyta Dorofeieva
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Investigation of the influence of structural inhomogeneities on the strength of welded joints of functionally gradient materials

Trudy Odesskogo Politehničeskogo Universiteta, 2020
The effect of defects on the mechanical properties of joints of functionally gradient materials, which depends on their shape, operating conditions, and the nature of the load, is considered.
Анатолiй Васильович Усов, Юрій Олександрович Морозов, Максим Володимирович Куніцин, Анатолій Мстиславович Тонконоженко, Ігор Олександрович Черниш   +4 more
doaj  

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

ASSESSMENT OF THE ADEQUACY OF THE LOTKA – VOLTERRA MODEL FOR DETERMINING HUMAN ECOLOGICAL WELL-BEING

Измерение, мониторинг, управление, контроль
Background. The use of mathematics in the field of environmental safety has long roots. The most famous mathematical model in ecology is the Lotka – Volterra model, which describes the relationship between predator and prey in a natural ecosystem.
O.E. Bezborodova, O.N. Bodin, K.D. Mishina, D.V. Novikov, D.V. Martynov   +4 more
doaj   +1 more source

REDEFINING OF SOLUTE TRANSPORT GROUPS IN CONTINUOUS PERITONEAL DIALYSIS PATIENTS AND COMPARISON WITH PREVIOUS REPORTS

Turkish Journal of Nephrology, 2019
Peritoneal equilibration test (PET) is the most practical way to monitor the peritoneal transport characterististics and it is recommended to be obtained twice a year.
Bülent TOKGÖZ, Oktay OYMAK, H. Murat SİPAHİOĞLU, Cengiz UTAŞ   +3 more
doaj  

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source