Results 101 to 110 of about 2,532,336 (393)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

α-Mangostin hydrogel film with chitosan alginate base for recurrent aphthous stomatitis (RAS) treatment: study protocol for double-blind randomized controlled trial

Frontiers in Pharmacology
Background: Recurrent Aphthous Stomatitis (RAS) is a common ulcerative disease of the oral mucosa which is characterized by pain, and recurrent lesions in the oral cavity.
Cszahreyloren Vitamia, Cszahreyloren Vitamia, Cszahreyloren Vitamia, Ghina Nadhifah Iftinan, Irma Rahayu Latarissa, Gofarana Wilar, Arief Cahyanto, Ahmed Fouad Abdelwahab Mohammed, Ali El-Rayyes, Nasrul Wathoni, Nasrul Wathoni   +10 more
doaj   +1 more source

Adesão à profilaxia pós-exposição utilizada para HIV: uma revisão integrativa / Post-exposure prophylaxis used for HIV adherence: an integrative review [PDF]

, 2022
Gabriela da Silva Pelegrino, Jéssica Maria Vioto, Leandra Ernst Kerche   +2 more
openalex   +1 more source

Long-term prediction of adherence to continuous positive air pressure therapy for the treatment of moderate/severe obstructive sleep apnea syndrome [PDF]

, 2018
BACKGROUND: Continuous positive airway pressure (CPAP) therapy is a highly effective treatment for obstructive sleep apnea syndrome (OSAS). However, poor adherence is a limiting factor, and a significant proportion of patients are unable to tolerate CPAP.
Angelico F, Baratta F, Brunori M, Bucci T, Del Ben M, Fabiani M, Fabiani V, Lillo R, Loffredo L, Pannitteri G, Pastori D   +10 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Sociodemographic and clinical predictors of adherence to antidepressants in depressive disorders: a systematic review with a meta-analysis

Frontiers in Pharmacology
Introduction: Current evidence reveals concerning rates of non-adherence to antidepressant treatment, possibly influenced by various relevant determinants such as sociodemographic factors or those related to the health system and their professionals. The
Tasmania Del Pino-Sedeño, Tasmania Del Pino-Sedeño, Tasmania Del Pino-Sedeño, Tasmania Del Pino-Sedeño, Tasmania Del Pino-Sedeño, Diego Infante-Ventura, Diego Infante-Ventura, Diego Infante-Ventura, Diego Hernández-González, Yadira González-Hernández, Yadira González-Hernández, Beatriz González de León, Amado Rivero-Santana, Amado Rivero-Santana, Amado Rivero-Santana, Isabel Hurtado, Isabel Hurtado, Francisco Javier Acosta Artiles, Francisco Javier Acosta Artiles   +18 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Mediterranean diet adherence and synergy with acute myocardial infarction and its determinants. a multicenter case-control study in Italy. [PDF]

, 2018
Cardiovascular diseases are the leading causes of mortality and morbidity in Western countries. The possible synergistic effect of poor adherence to a Mediterranean diet (MD) and other risk factors for acute myocardial infarction (AMI) such as ...
Agati, L, Barillà, F, Colamesta, V, Di Murro, F, Ferrante, F, Firenze, A, La Torre, G, Mannocci, A, Maurici, M, Saulle, R, Siliquini, R   +10 more
core   +1 more source

Adherence interventions and outcomes of tuberculosis treatment: A systematic review and meta-analysis of trials and observational studies

PLoS Medicine, 2018
Background Incomplete adherence to tuberculosis (TB) treatment increases the risk of delayed culture conversion with continued transmission in the community, as well as treatment failure, relapse, and development or amplification of drug resistance.
N. Alipanah, L. Jarlsberg, Cecily R. Miller, N. Linh, D. Falzon, E. Jaramillo, P. Nahid   +6 more
semanticscholar   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source