Results 161 to 170 of about 52,251 (235)

Adherens junction engagement regulates functional patterning of the cardiac pacemaker cell lineage. [PDF]

Dev Cell, 2021
Thomas K, Henley T, Rossi S, Costello MJ, Polacheck W, Griffith BE, Bressan M.   +6 more
europepmc   +1 more source

Arginase 2 Promotes Colorectal Cancer Metastasis via PI3K/AKT Pathway Activation and Regulates Tumor Immune Infiltration

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Background Colorectal cancer (CRC) is a leading cause of cancer‐related deaths, with metabolic reprogramming involved in its pathogenesis. Aberrant Arginase 2 (ARG2) expression is linked to malignant progression, but its role in CRC remains unclear. Methods ARG2 expression in CRC and adjacent tissues was analyzed.
Yueyan Zhang, Ning Qu, Jiale Mei, Caixia Mo, Luojuan Wei, Haixian Shen, Shanfei Zhou, Jinmin Hu, Wenqi Luo, Xianwei Mo   +9 more
wiley   +1 more source

Lasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis. [PDF]

Nat Commun, 2021
Beckmann D, Römer-Hillmann A, Krause A, Hansen U, Wehmeyer C, Intemann J, de Gorter DJJ, Dankbar B, Hillen J, Heitzmann M, Begemann I, Galic M, Weinhage T, Foell D, Ai R, Kremerskothen J, Kiener HP, Müller S, Kamradt T, Schröder C, Leitão E, Horsthemke B, Rosenstiel P, Nordström K, Gasparoni G, Gasparoni N, Walter J, Li N, Yang X, Chung HR, Pavenstädt H, Lindemann N, Schnittler HJ, Wang W, Firestein GS, Pap T, Korb-Pap A.   +36 more
europepmc   +1 more source

Paxillin promotes breast tumor collective cell invasion through maintenance of adherens junction integrity. [PDF]

Mol Biol Cell, 2022
Xu W, Alpha KM, Zehrbach NM, Turner CE.
europepmc   +1 more source

Ventilator‐Induced Lung Injury: Mechanotransduction and Potential Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Mechanical ventilation (MV) is expected to undergo significant transformative advancements by 2050, with the emergence of personalized ventilation systems that promise to revolutionize respiratory care. However, the risk of ventilator‐induced lung injury (VILI) remains a significant concern at this stage and VILI still exists at that time.
He Ren, Ziqi Shang, Alastair G. Stewart, Ying‐xin Qi, Kai Huang   +4 more
wiley   +1 more source

The Novel ROCK Inhibitor Fasudil Derivative Fasudil-D-6h Prevents Tumour Progression by Regulating the Adherens Junction Signalling Pathway in Triple-Negative Breast Cancer

Breast Cancer: Targets and Therapy
Jinghui Liang,1 Mu Tang,2 Lieliang Wang2 1Department of Comprehensive Radiotherapy, Jiangxi Cancer Hospital & Institute, Nanchang City, Jiangxi Province, People’s Republic of China; 2Department of Breast Surgery, Jiangxi Cancer Hospital & ...
Liang J, Tang M, Wang L
doaj  

Tissue fluidity mediated by adherens junction dynamics promotes planar cell polarity-driven ommatidial rotation. [PDF]

Nat Commun, 2021
Founounou N, Farhadifar R, Collu GM, Weber U, Shelley MJ, Mlodzik M.   +5 more
europepmc   +1 more source

Distinct Roles of IL‐4, IL‐13, and IL‐22 in Human Skin Barrier Dysfunction and Atopic Dermatitis

Allergy, Volume 81, Issue 2, Page 480-497, February 2026.
This study reports the distinct effects of IL‐4, IL‐13, and IL‐22 on bio‐stabilized human skin with intact barriers and immune cells. IL‐4, IL‐13, and IL‐22 upregulate inflammatory mediators, disrupt skin barrier integrity, and reciprocally modulate IL‐4Rα and IL‐22Rα1 receptors.
Paolo D'Avino, Juno Kim, Manru Li, Philipp Gessner, Patrick Westermann, Yagız Pat, Carina Beha, Claudia Traidl‐Hoffmann, Jeremy Bost, Nicolas Gaudenzio, Christoph B. Messner, Cezmi A. Akdis, Yasutaka Mitamura   +12 more
wiley   +1 more source

Alterations in Gut Microbiota and Metabolism in Cirrhotic Portal Hypertension: Implications for Disease Progression

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 4, Page 538-556, February 2026.
In‐depth multiomics analyses revealed that the gut microbiota in patients with CPH is dysbiotic. Altered gut microbiota plays an important role in the progression of CPH and affects the host's arginine metabolism to promote arginine biosynthesis. The pro‐inflammatory effects of certain gut bacteria induce iNOS expression, which together act on the ...
Qun Zhang, Jinghua Cui, Yixin Hou, Lining Guo, Hai Li, Guiqin Zhou, Xiaojing Wang, Bingbing Zhu, Ke Shi, Yi Zhang, Yufei Bi, Yanqiu Li, Lina Sun, Ying Feng, Jing Yuan, Xianbo Wang   +15 more
wiley   +1 more source

Effect of Graphene and Graphene Oxide on Airway Barrier and Differential Phosphorylation of Proteins in Tight and Adherens Junction Pathways. [PDF]

Nanomaterials (Basel), 2021
Van Den Broucke S, Vanoirbeek JAJ, Derua R, Hoet PHM, Ghosh M.   +4 more
europepmc   +1 more source