Results 211 to 220 of about 51,811 (246)
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2012
Cadherins and catenins are the central cell-cell adhesion molecules in adherens junctions (AJs). This chapter reviews the knowledge concerning the role of cadherins and catenins in epithelial cancer and examines the published literature demonstrating the changes in the expression and function of these proteins in human cancer and the association of ...
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Cadherins and catenins are the central cell-cell adhesion molecules in adherens junctions (AJs). This chapter reviews the knowledge concerning the role of cadherins and catenins in epithelial cancer and examines the published literature demonstrating the changes in the expression and function of these proteins in human cancer and the association of ...
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Associated proteins of lens adherens junction
Journal of Cellular Biochemistry, 2002AbstractCytoplasmic proteins associated with adherens junctions were identified in the chicken ocular lens. The catenins, α, β, and γ, were present in epithelial and fiber cells, although their pattern of distribution changed with fiber cell differentiation. The sharp decline in α‐catenin with fiber cell formation and the increasing Triton‐insolubility
M, Bagchi, M, Katar, J, Lewis, H, Maisel
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Molecular architecture of adherens junctions
Current Opinion in Cell Biology, 2001Adherens junctions are composed of a cadherin-catenin complex and its associated proteins. Recently, an increasing number of novel members of adherens junctions, including membrane and PDZ proteins, have been reported. Interactions among these components in adherens junctions seem to be dynamically regulated during the formation of adherens junction ...
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Adherens junctions in Drosophila retinal morphogenesis
Trends in Cell Biology, 2007Adherens junctions and their core molecular components, classic cadherins, make major contributions to animal morphogenesis. Although the significance of cadherins in development is generally accepted, the mechanisms regulating adherens junction function during morphogenesis remain a subject of intense research.
Ulrich, Tepass, Kathryn P, Harris
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Adherens junction treadmilling during collective migration
Nature Cell Biology, 2014Collective cell migration is essential for both physiological and pathological processes. Adherens junctions (AJs) maintain the integrity of the migrating cell group and promote cell coordination while allowing cellular rearrangements. Here, we show that AJs undergo a continuous treadmilling along the lateral sides of adjacent leading cells.
Peglion, Florent +2 more
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Adherens Junctions During Cell Migration
2012Migration is a key cellular process, involved during morphogenetic movements as well as in the adult where it participates in immune cell trafficking, wound healing or tumour invasion. As they migrate, cells interact with a microenvironment composed of extracellular matrix and neighbouring cells.
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EphA2 Destabilizes Adherens Junctions
Science Signaling, 2008Ephs are receptor tyrosine kinases that are activated by membrane-bound ephrin ligands on adjacent cells. The Eph-ephrin system plays an important role in coordinating cell movement and organization in development. Some Ephs are associated with certain cancers, and their abundance in cancer cells seems to correlate with tumor malignancy ...
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α-catenin mechanosensing for adherens junctions
Nature Cell Biology, 2010The balance of cohesion and remodelling is essential for the integrity and morphogenesis of epithelia. This requires adhesion and transmission of actomyosin tension, both of which are mediated by E-cadherin. The finding that actomyosin tension reinforces mechanical coupling of actin to E-cadherin through alpha-catenin reveals similarities with integrin
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Trypanosoma cruzi alters adherens junctions in cardiomyocytes
Microbes and Infection, 2008We analyzed the distribution and expression of cadherin and beta-catenin during Trypanosoma cruzi-cardiomyocyte interaction. Confocal microscopy revealed cadherin associated with beta-catenin at the cell-cell contacts. After 24h of infection, the spatial distribution and expression of both adherens junction (AJ) proteins remained unaltered. In contrast,
Tatiana G, de Melo +2 more
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Immunoglobulin Superfamily Receptors and Adherens Junctions
2012The immunogroblin (Ig) superfamily proteins characterized by the presence of Ig-like domains are involved in various cellular functions. The properties of the Ig-like domains to form rod-like structures and to bind specifically to other proteins make them ideal for cell surface receptors and cell adhesion molecules (CAMs).
Yohei, Shimono +4 more
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