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Trends in Cell Biology, 2002
E-cadherin-based adherens junctions are required for proper adhesion and orientation of epithelial cells within a sheet, as well as playing a role in asymmetric cell division. Although a lot is known – about how E-cadherin-based junctions link to the cytoskeleton, much less is known – about how their localization in the cell is controlled.
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E-cadherin-based adherens junctions are required for proper adhesion and orientation of epithelial cells within a sheet, as well as playing a role in asymmetric cell division. Although a lot is known – about how E-cadherin-based junctions link to the cytoskeleton, much less is known – about how their localization in the cell is controlled.
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Adherens Junctions and Cadherins in Drosophila Development
2012Drosophila represents a paradigm for the analysis of the cellular, molecular and genetic mechanisms of development and is an ideal model system to study the contribution of Adherens Junctions (AJs) and their major components, cadherins, to morphogenesis.
Annalisa, Letizia, Marta, Llimargas
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Structural Aspects of Adherens Junctions and Desmosomes
2004The cadherin-containing intercellular junctions, adherens junctions and desmosomes share an overall logical organization in which the extracellular regions of the cadherins on opposing cells interact, while their cytoplasmic domains are linked to the cytoskeleton through protein assemblies.
H-J, Choi, W I, Weis
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Adherens junctions: from molecules to morphogenesis
Nature Reviews Molecular Cell Biology, 2010How adhesive interactions between cells generate and maintain animal tissue structure remains one of the most challenging and long-standing questions in cell and developmental biology. Adherens junctions (AJs) and the cadherin-catenin complexes at their core are therefore the subjects of intense research.
Tony J C, Harris, Ulrich, Tepass
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α-catenin mechanosensing for adherens junctions
Nature Cell Biology, 2010The balance of cohesion and remodelling is essential for the integrity and morphogenesis of epithelia. This requires adhesion and transmission of actomyosin tension, both of which are mediated by E-cadherin. The finding that actomyosin tension reinforces mechanical coupling of actin to E-cadherin through alpha-catenin reveals similarities with integrin
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Adherens Junctions During Cell Migration
2012Migration is a key cellular process, involved during morphogenetic movements as well as in the adult where it participates in immune cell trafficking, wound healing or tumour invasion. As they migrate, cells interact with a microenvironment composed of extracellular matrix and neighbouring cells.
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Immunoglobulin Superfamily Receptors and Adherens Junctions
2012The immunogroblin (Ig) superfamily proteins characterized by the presence of Ig-like domains are involved in various cellular functions. The properties of the Ig-like domains to form rod-like structures and to bind specifically to other proteins make them ideal for cell surface receptors and cell adhesion molecules (CAMs).
Yohei, Shimono +4 more
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Cadherin–actin interactions at adherens junctions
Current Opinion in Cell Biology, 2011The adherens junction (AJ) is a major cell-cell junction that mediates cell recognition, adhesion, morphogenesis, and tissue integrity. Although AJs transmit forces generated by actomyosin from one cell to another, AJs have long been considered as an area where signal transduction from cadherin ligation takes place through cell adhesion.
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