Results 221 to 230 of about 52,251 (235)
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EphA2 Destabilizes Adherens Junctions
Science Signaling, 2008Ephs are receptor tyrosine kinases that are activated by membrane-bound ephrin ligands on adjacent cells. The Eph-ephrin system plays an important role in coordinating cell movement and organization in development. Some Ephs are associated with certain cancers, and their abundance in cancer cells seems to correlate with tumor malignancy ...
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Adherens junctions: from molecules to morphogenesis
Nature Reviews Molecular Cell Biology, 2010How adhesive interactions between cells generate and maintain animal tissue structure remains one of the most challenging and long-standing questions in cell and developmental biology. Adherens junctions (AJs) and the cadherin-catenin complexes at their core are therefore the subjects of intense research.
Tony J C, Harris, Ulrich, Tepass
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α-catenin mechanosensing for adherens junctions
Nature Cell Biology, 2010The balance of cohesion and remodelling is essential for the integrity and morphogenesis of epithelia. This requires adhesion and transmission of actomyosin tension, both of which are mediated by E-cadherin. The finding that actomyosin tension reinforces mechanical coupling of actin to E-cadherin through alpha-catenin reveals similarities with integrin
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Trypanosoma cruzi alters adherens junctions in cardiomyocytes
Microbes and Infection, 2008We analyzed the distribution and expression of cadherin and beta-catenin during Trypanosoma cruzi-cardiomyocyte interaction. Confocal microscopy revealed cadherin associated with beta-catenin at the cell-cell contacts. After 24h of infection, the spatial distribution and expression of both adherens junction (AJ) proteins remained unaltered. In contrast,
Tatiana G, de Melo +2 more
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Immunoglobulin Superfamily Receptors and Adherens Junctions
2012The immunogroblin (Ig) superfamily proteins characterized by the presence of Ig-like domains are involved in various cellular functions. The properties of the Ig-like domains to form rod-like structures and to bind specifically to other proteins make them ideal for cell surface receptors and cell adhesion molecules (CAMs).
Yohei, Shimono +4 more
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Cadherin–actin interactions at adherens junctions
Current Opinion in Cell Biology, 2011The adherens junction (AJ) is a major cell-cell junction that mediates cell recognition, adhesion, morphogenesis, and tissue integrity. Although AJs transmit forces generated by actomyosin from one cell to another, AJs have long been considered as an area where signal transduction from cadherin ligation takes place through cell adhesion.
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