Results 71 to 80 of about 52,251 (235)

Appropriate tension sensitivity of α-catenin ensures rounding morphogenesis of epithelial spheroids

Cell Structure and Function, 2022
The adherens junction (AJ) is an actin filament-anchoring junction. It plays a central role in epithelial morphogenesis through cadherin-based recognition and adhesion among cells.
Ryosuke Nishimura, Kagayaki Kato, Misako Saida, Yasuhiro Kamei, Masahiro Takeda, Hiromi Miyoshi, Yutaka Yamagata, Yu Amano, Shigenobu Yonemura   +8 more
doaj   +1 more source

PKCα and CPI-17 expression and spatial-temporal distribution with activation in pig stomach antrum and fundus [PDF]

, 2010
Smooth muscle contraction is a complicated process coordinated by contractile, regulatory and cytoskeletal proteins. The force generation depends on the phosphorylation of Myosin Regulatory Light Chain (MLC20). Myosin Light Chain Kinase (MLCK) and Myosin
Zhang, Yu
core   +1 more source

E-cadherin and cell adhesion: a role in architecture and function in the pancreatic islet [PDF]

, 2007
Background/Aims: The efficient secretion of insulin from beta-cells requires extensive intra-islet communication. The cell surface adhesion protein epithelial (E)-cadherin (ECAD) establishes and maintains epithelial tissues such as the islets of ...
Bamji SX, Braga VMM, Brereton HC, Cabrera O, Collares-Buzato CB, Dahl U, Gareth J. Rogers, Gey GO, Gray E, Hellman B, Hills CE, Hodgkin MN, Kanno Y, Matsuda T, Matthew N. Hodgkin, Musil LS, Paul E. Squires, Piccoli G, Shih DQ, Squires PE, Squires PE, Woodfield RJ   +21 more
core   +1 more source

Tunable Bioresorbable Scaffolds With Marine Sulfated Polysaccharides for Small‐Caliber Vascular Grafts: A Multi‐Layered Strategy Combining Electrospinning and 4‐Axis Printing

Advanced Healthcare Materials, EarlyView.
A multilayered small‐caliber vascular scaffold combining electrospinning and 4‐axis printing is developed and biofunctionalized with marine sulfated polysaccharides from Holothuria tubulosa. The resulting construct exhibits enhanced hemocompatibility, tunable mechanical properties, and supports endothelial and smooth muscle cell adhesion and ...
Gabriele Obino, Alberto Sensini, Tim ten Brink, Gabriele Nieddu, Tristan Bodet, Giovanni Andrea Deiana, Martijn van Griensven, Marilena Formato, Antonio J. Lepedda, Lorenzo Moroni   +9 more
wiley   +1 more source

Ve-ptp modulates vascular integrity by promoting adherens junction maturation. [PDF]

PLoS ONE, 2012
BACKGROUND: Endothelial cell junctions control blood vessel permeability. Altered permeability can be associated with vascular fragility that leads to vessel weakness and haemorrhage formation.
Silvia Carra, Efrem Foglia, Solei Cermenati, Erica Bresciani, Costanza Giampietro, Carla Lora Lamia, Elisabetta Dejana, Monica Beltrame, Franco Cotelli   +8 more
doaj   +1 more source

Mechanisms of Intestinal Epithelial Barrier Dysfunction by Adherent-Invasive Escherichia coli. [PDF]

, 2016
Pathobiont expansion, such as that of adherent-invasive Escherichia coli (AIEC), is an emerging factor associated with inflammatory bowel disease. The intestinal epithelial barrier is the first line of defense against these pathogens.
McCole, Declan F, Shawki, Ali
core   +1 more source

Tight Junctions/Adherens Junctions: Basic Structure and Function [PDF]

Journal of Investigative Dermatology, 2007
Adherens and tight junctions are intercellular junctions crucial for epithelial adhesion and barrier function in a wide variety of tissues and organisms. In stratifying epithelia, such as the epidermis, the role of adherens and tight junctions was considered less important owing to the abundance of desmosomes, mediating firm mechanical stability ...
openaire   +2 more sources

A New 3D Colon on a Chip to Decipher the Influence of Mechanical Forces on the Physiological Cellular Ecosystem

Advanced Healthcare Materials, EarlyView.
To dissect how mechanical forces influence intestinal physiology, we developed a stretchable 3D colon‐on‐chip that integrates tunable topography, stiffness and peristalsis‐like motion within a physiologically relevant microenvironment. We showed that stretching is a dominant factor governing epithelial behavior, markedly enhancing proliferation and ...
Moencopi Bernheim‐Dennery, Lauriane Gérémie, Julie Brun, Lucas Chassatte, Giacomo Gropplero, Réda Bouras, Jieun Choo, Bertrand Cinquin, Alba Marcellan, Danijela Matic Vignjevic, Stéphanie Descroix   +10 more
wiley   +1 more source

Identification of PKN2 and MOB4 as Coordinators of Collective Cell Migration

Advanced Science, EarlyView.
Through a genetic screen, PKN2 and MOB4 are identified as two proteins regulating the healing of an epithelial model wound. PKN2 promotes collective cell migration by maintaining the cohesion of cell monolayers from their lateral junctions, whereas MOB4 restrains collective cell migration and provides a lamellipodial cue for front‐rear polarity in ...
Artem I. Fokin, Yueying Lin, Dmitry Y. Guschin, Hsiang‐Ying Chen, John James, Jie Yan, Pascal Silberzan, Alexis M. Gautreau   +7 more
wiley   +1 more source

Adherens junction distribution mechanisms during cell-cell contact elongation in Drosophila. [PDF]

PLoS ONE, 2013
During Drosophila gastrulation, amnioserosa (AS) cells flatten and spread as an epithelial sheet. We used AS morphogenesis as a model to investigate how adherens junctions (AJs) distribute along elongating cell-cell contacts in vivo.
Gabrielle Goldenberg, Tony J C Harris
doaj   +1 more source