Results 61 to 70 of about 51,811 (246)
PLoS ONE, 2011 During development of the central nervous system, the apical-basal polarity of neuroepithelial cells is critical for homeostasis of proliferation and differentiation of neural stem cells.
Dean Thumkeo +8 more
doaj +1 more source
The Retinoblastoma Tumor Suppressor Transcriptionally Represses Pak1 in Osteoblasts. [PDF]
PLoS ONE, 2015 We previously characterized the retinoblastoma tumor suppressor protein (Rb) as a regulator of adherens junction assembly and cell-to-cell adhesion in osteoblasts. This is a novel function since Rb is predominantly known as a cell cycle repressor. Herein,
Bernadette Sosa-García +5 more
doaj +1 more source
Advanced Science, EarlyView.ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang +8 more
wiley +1 more source
Heart of glass anchors Rasip1 at endothelial cell-cell junctions to support vascular integrity. [PDF]
, 2016 Heart of Glass (HEG1), a transmembrane receptor, and Rasip1, an endothelial-specific Rap1-binding protein, are both essential for cardiovascular development.
de Kreuk, Bart-Jan +5 more
core +2 more sources
Adherens Junctions: Guardians of Cortical Development
Frontiers in Cell and Developmental Biology, 2020 Apical radial glia comprise the pseudostratified neuroepithelium lining the embryonic lateral ventricles and give rise to the extensive repertoire of pyramidal neuronal subtypes of the neocortex. The establishment of a highly apicobasally polarized radial glial morphology is a mandatory prerequisite for cortical development as it governs neurogenesis ...
Veeraval, Lenin +2 more
openaire +4 more sources
Afadin controls cell polarization and mitotic spindle orientation in developing cortical radial glia
Neural Development, 2017 Background In developing tissues, cell polarity and tissue architecture play essential roles in the regulation of proliferation and differentiation. During cerebral cortical development, adherens junctions link highly polarized radial glial cells in a ...
Jennifer Rakotomamonjy +6 more
doaj +1 more source
Ve-ptp modulates vascular integrity by promoting adherens junction maturation. [PDF]
PLoS ONE, 2012 BACKGROUND: Endothelial cell junctions control blood vessel permeability. Altered permeability can be associated with vascular fragility that leads to vessel weakness and haemorrhage formation.
Silvia Carra +8 more
doaj +1 more source
Appropriate tension sensitivity of α-catenin ensures rounding morphogenesis of epithelial spheroids
Cell Structure and Function, 2022 The adherens junction (AJ) is an actin filament-anchoring junction. It plays a central role in epithelial morphogenesis through cadherin-based recognition and adhesion among cells.
Ryosuke Nishimura +8 more
doaj +1 more source
Advanced Science, EarlyView.Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang +3 more
wiley +1 more source
Robustness of force and stress inference in an epithelial tissue
, 2014 During morphogenesis, the shape of a tissue emerges from collective cellular behaviors, which are in part regulated by mechanical and biochemical interactions between cells.
Bellaïche, Y. +4 more
core +1 more source