Results 81 to 90 of about 51,811 (246)
Adherens Junctions and Stem Cells [PDF]
, 2012 The specification, maintenance, division and differentiation of stem cells are integral to the development and homeostasis of many tissues. These stem cells often live in specialized anatomical areas, called niches. While niches can be complex, most involve cell-cell interactions that are mediated by adherens junctions.
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eLife, 2017 Detachment of newborn neurons from the neuroepithelium is required for correct neuronal architecture and functional circuitry. This process, also known as delamination, involves adherens-junction disassembly and acto-myosin-mediated abscission, during ...
Ioannis Kasioulis +2 more
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Advanced Science, EarlyView.Gastric cancer‐derived exosomal TAGLN2 is identified as a key mediator of vascular reprogramming, with significantly elevated levels detected in patient serum. Independent of canonical SEMA4D signaling, it nucleates a cytoplasmic TAGLN2/NRP1/SEMA4D ternary complex that dually activates YAP, promoting angiogenesis, vascular dysfunction, and metastasis ...
Shuqi Yu +7 more
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PKCα and CPI-17 expression and spatial-temporal distribution with activation in pig stomach antrum and fundus [PDF]
, 2010 Smooth muscle contraction is a complicated process coordinated by contractile, regulatory and cytoskeletal proteins. The force generation depends on the phosphorylation of Myosin Regulatory Light Chain (MLC20). Myosin Light Chain Kinase (MLCK) and Myosin
Zhang, Yu
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Could an endoneurial endothelial crosstalk between Wnt/β-catenin and Sonic Hedgehog pathways underlie the early disruption of the infra-orbital blood-nerve barrier following chronic constriction injury? [PDF]
, 2017 BackgroundBlood–nerve barrier disruption is pivotal in the development of neuroinflammation, peripheral sensitization, and neuropathic pain after peripheral nerve injury.
Boucher, Yves +7 more
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The Journal of Cell Biology, 2005 The textbook model of adherens junctions has been exploded, or severed, by Bill Weis, Soichiro Yamada, Frauke Drees, Sabine Pokutta, and W. James Nelson (Stanford University School of Medicine, Stanford, CA). There is no direct link, they say, between cadherin, via β- and α-catenin, to actin.
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Advanced Science, EarlyView.Laterally spreading tumors (LSTs) are precancerous colorectal lesions characterized by a flat morphology. This study reveals a mechanochemical pathway through which a soft matrix microenvironment diminishes spatial constraints in intestinal adenomas. This process promotes deficiencies in tight junction proteins, mediated by the mechanoreceptor ADORA2B ...
Jiamin Zhong +21 more
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, 2016 We generated a computational approach to analyze the biomechanics of epithelial cell aggregates, either island or stripes or entire monolayers, that combines both vertex and contact-inhibition-of-locomotion models to include both cell-cell and cell ...
Caldwell, Benjamin J. +11 more
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Gap junction reduction in cardiomyocytes following transforming growth factor- beta treatment and Trypanosoma cruzi infection [PDF]
, 2009 Gap junction connexin-43 (Cx43) molecules are responsible for electrical impulse conduction in the heart and are affected by transforming growth factor-beta (TGF-beta).
Becker, D +6 more
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Plasmalogen mediates integration of adherens junction
The Journal of Biochemistry, 2019 AbstractEther glycerolipids, plasmalogens are found in various mammalian cells and tissues. However, physiological role of plasmalogens in epithelial cells remains unknown. We herein show that synthesis of ethanolamine-containing plasmalogens, plasmenylethanolamine (PlsEtn), is deficient in MCF7 cells, an epithelial cell line, with severely reduced ...
Takanori Takahashi +3 more
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