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Adherens junctions: from molecules to morphogenesis
Nature Reviews Molecular Cell Biology, 2010How adhesive interactions between cells generate and maintain animal tissue structure remains one of the most challenging and long-standing questions in cell and developmental biology. Adherens junctions (AJs) and the cadherin-catenin complexes at their core are therefore the subjects of intense research.
Tony J C Harris
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Endothelial adherens junctions at a glance
Journal of Cell Science, 2013Adherens junctions have an important role in the control of vascular permeability. These structures are located at cell-to-cell contacts, mediate cell adhesion and transfer intracellular signals. Adhesion is mediated by cadherins, which interact homophilically in trans and form lateral interactions in cis.
E. Dejana, F. Orsenigo
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Trends in Cell Biology, 2002
E-cadherin-based adherens junctions are required for proper adhesion and orientation of epithelial cells within a sheet, as well as playing a role in asymmetric cell division. Although a lot is known – about how E-cadherin-based junctions link to the cytoskeleton, much less is known – about how their localization in the cell is controlled.
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E-cadherin-based adherens junctions are required for proper adhesion and orientation of epithelial cells within a sheet, as well as playing a role in asymmetric cell division. Although a lot is known – about how E-cadherin-based junctions link to the cytoskeleton, much less is known – about how their localization in the cell is controlled.
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Adherens Junctions and Pathogen Entry
2012Epithelia are highly organised structures protecting underlying tissues against microbial pathogens. Epithelial morphogenesis and maintenance is mediated by cell-cell adhesion molecules organised in junctional complexes, such as the adherens junctions.
Georgios, Nikitas, Pascale, Cossart
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Adherens junctions of the human detrusor
BJU International, 2005OBJECTIVE To immunohistochemically identify the protein composition of adherens junctions, which couple smooth muscle cells mechanically, and to confirm their decrease in different bladder dysfunctions, as studies in geriatric bladder dysfunction show fewer such junctions in patients with detrusor overactivity ...
Nina, Wagener +8 more
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Nature Cell Biology, 2004
Epithelial cells are joined by adherens junctions, which consist of homotypic interactions between extracellular domains of E-cadherins. Inside the cell, the tails of E-cadherins bind actin cables through β-catenin and α-catenin. Formin1 is critically important for the formation of actin cables; it binds directly to α-catenin and can even bypass the ...
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Epithelial cells are joined by adherens junctions, which consist of homotypic interactions between extracellular domains of E-cadherins. Inside the cell, the tails of E-cadherins bind actin cables through β-catenin and α-catenin. Formin1 is critically important for the formation of actin cables; it binds directly to α-catenin and can even bypass the ...
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2012
Cadherins and catenins are the central cell-cell adhesion molecules in adherens junctions (AJs). This chapter reviews the knowledge concerning the role of cadherins and catenins in epithelial cancer and examines the published literature demonstrating the changes in the expression and function of these proteins in human cancer and the association of ...
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Cadherins and catenins are the central cell-cell adhesion molecules in adherens junctions (AJs). This chapter reviews the knowledge concerning the role of cadherins and catenins in epithelial cancer and examines the published literature demonstrating the changes in the expression and function of these proteins in human cancer and the association of ...
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Associated proteins of lens adherens junction
Journal of Cellular Biochemistry, 2002AbstractCytoplasmic proteins associated with adherens junctions were identified in the chicken ocular lens. The catenins, α, β, and γ, were present in epithelial and fiber cells, although their pattern of distribution changed with fiber cell differentiation. The sharp decline in α‐catenin with fiber cell formation and the increasing Triton‐insolubility
M, Bagchi, M, Katar, J, Lewis, H, Maisel
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Molecular architecture of adherens junctions
Current Opinion in Cell Biology, 2001Adherens junctions are composed of a cadherin-catenin complex and its associated proteins. Recently, an increasing number of novel members of adherens junctions, including membrane and PDZ proteins, have been reported. Interactions among these components in adherens junctions seem to be dynamically regulated during the formation of adherens junction ...
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Adherens junctions in Drosophila retinal morphogenesis
Trends in Cell Biology, 2007Adherens junctions and their core molecular components, classic cadherins, make major contributions to animal morphogenesis. Although the significance of cadherins in development is generally accepted, the mechanisms regulating adherens junction function during morphogenesis remain a subject of intense research.
Ulrich, Tepass, Kathryn P, Harris
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