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Nature Cell Biology, 2004
Epithelial cells are joined by adherens junctions, which consist of homotypic interactions between extracellular domains of E-cadherins. Inside the cell, the tails of E-cadherins bind actin cables through β-catenin and α-catenin. Formin1 is critically important for the formation of actin cables; it binds directly to α-catenin and can even bypass the ...
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Epithelial cells are joined by adherens junctions, which consist of homotypic interactions between extracellular domains of E-cadherins. Inside the cell, the tails of E-cadherins bind actin cables through β-catenin and α-catenin. Formin1 is critically important for the formation of actin cables; it binds directly to α-catenin and can even bypass the ...
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Structural Aspects of Adherens Junctions and Desmosomes
2004The cadherin-containing intercellular junctions, adherens junctions and desmosomes share an overall logical organization in which the extracellular regions of the cadherins on opposing cells interact, while their cytoplasmic domains are linked to the cytoskeleton through protein assemblies.
H-J, Choi, W I, Weis
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Adherens junctions in Drosophila retinal morphogenesis
Trends in Cell Biology, 2007Adherens junctions and their core molecular components, classic cadherins, make major contributions to animal morphogenesis. Although the significance of cadherins in development is generally accepted, the mechanisms regulating adherens junction function during morphogenesis remain a subject of intense research.
Ulrich, Tepass, Kathryn P, Harris
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α-catenin mechanosensing for adherens junctions
Nature Cell Biology, 2010The balance of cohesion and remodelling is essential for the integrity and morphogenesis of epithelia. This requires adhesion and transmission of actomyosin tension, both of which are mediated by E-cadherin. The finding that actomyosin tension reinforces mechanical coupling of actin to E-cadherin through alpha-catenin reveals similarities with integrin
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Cadherin–actin interactions at adherens junctions
Current Opinion in Cell Biology, 2011The adherens junction (AJ) is a major cell-cell junction that mediates cell recognition, adhesion, morphogenesis, and tissue integrity. Although AJs transmit forces generated by actomyosin from one cell to another, AJs have long been considered as an area where signal transduction from cadherin ligation takes place through cell adhesion.
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Adherens Junctions During Cell Migration
2012Migration is a key cellular process, involved during morphogenetic movements as well as in the adult where it participates in immune cell trafficking, wound healing or tumour invasion. As they migrate, cells interact with a microenvironment composed of extracellular matrix and neighbouring cells.
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Adherens junctions as molecular regulators of emergent tissue mechanics
Nature Reviews Molecular Cell Biology, 2023Otger Campas +2 more
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