Results 1 to 10 of about 1,307,359 (192)

Discovery of fibrillar adhesins across bacterial species [PDF]

BMC Genomics, 2021
Background Fibrillar adhesins are long multidomain proteins that form filamentous structures at the cell surface of bacteria. They are an important yet understudied class of proteins composed of adhesive and stalk domains that mediate interactions of ...
Vivian Monzon, Aleix Lafita, Alex Bateman   +2 more
doaj   +5 more sources

Platelets, Bacterial Adhesins and the Pneumococcus

Cells, 2022
Systemic infections with pathogenic or facultative pathogenic bacteria are associated with activation and aggregation of platelets leading to thrombocytopenia and activation of the clotting system.
Kristin Jahn, Thomas P. Kohler, Lena-Sophie Swiatek, Sergej Wiebe, Sven Hammerschmidt   +4 more
doaj   +4 more sources

Binding Strength of Gram-Positive Bacterial Adhesins [PDF]

Frontiers in Microbiology, 2020
Bacterial pathogens are equipped with specialized surface-exposed proteins that bind strongly to ligands on host tissues and biomaterials. These adhesins play critical roles during infection, especially during the early step of adhesion where the cells ...
Yves F. Dufrêne, Albertus Viljoen
doaj   +5 more sources

Sticking to the Subject: Multifunctionality in Microbial Adhesins

Journal of Fungi, 2023
Bacterial and fungal adhesins mediate microbial aggregation, biofilm formation, and adhesion to host. We divide these proteins into two major classes: professional adhesins and moonlighting adhesins that have a non-adhesive activity that is ...
Peter N. Lipke, Peleg Ragonis-Bachar
doaj   +2 more sources

Vibrio cholerae biofilms use modular adhesins with glycan-targeting and nonspecific surface binding domains for colonization

Nature Communications, 2023
Bacterial biofilms are formed on environmental surfaces and host tissues, and facilitate host colonization and antibiotic resistance by human pathogens.
Xin Huang, Thomas Nero, Ranjuna Weerasekera, Katherine H. Matej, Alex Hinbest, Zhaowei Jiang, Rebecca F. Lee, Longjun Wu, Cecilia Chak, Japinder Nijjer, Isabella Gibaldi, Hang Yang, Nathan Gamble, Wai-Leung Ng, Stacy A. Malaker, Kaelyn Sumigray, Rich Olson, Jing Yan   +17 more
doaj   +2 more sources

Adhesins in the virulence of opportunistic fungal pathogens of human

Mycology, 2021
Aspergillosis, candidiasis, and cryptococcosis are the most common cause of mycoses-related disease and death among immune-compromised patients. Adhesins are cell-surface exposed proteins or glycoproteins of pathogens that bind to the extracellular ...
Amrita Kumari, Ankita H. Tripathi, Poonam Gautam, Rekha Gahtori, Amit Pande, Yogendra Singh, Taruna Madan, Santosh K. Upadhyay   +7 more
doaj   +2 more sources

Helicobacter pylori employs a general protein glycosylation system for the modification of outer membrane adhesins

Gut Microbes, 2022
Helicobacter pylori infection is associated with the development of several gastric diseases including gastric cancer. To reach a long-term colonization in the host stomach, H.
Kai-Wen Teng, Kai-Siang Hsieh, Ji-Shiuan Hung, Chun-Jen Wang, En-Chi Liao, Pei-Chun Chen, Ying-Hsuan Lin, Deng-Chyang Wu, Chun-Hung Lin, Wen-Ching Wang, Hong-Lin Chan, Shau-Ku Huang, Mou-Chieh Kao   +12 more
doaj   +2 more sources

Bacterial adhesins in host-microbe interactions. [PDF]

Cell Host & Microbe, 2009
Most commensal and pathogenic bacteria interacting with eukaryotic hosts express adhesive molecules on their surfaces that promote interaction with host cell receptors or with soluble macromolecules. Even though bacterial attachment to epithelial cells may be beneficial for bacterial colonization, adhesion may come at a cost because bacterial ...
K. Kline, Stefan Fälker, S. Dahlberg, S. Normark, B. Henriques‐Normark   +4 more
semanticscholar   +3 more sources

Stopping Tuberculosis at the Gate: The Role of M. tuberculosis Adhesins in Infection and Intervention [PDF]

Vaccines
The global burden of tuberculosis (TB), exacerbated by the rise of drug-resistant Mycobacterium tuberculosis (M. tuberculosis), underscores the need for alternative intervention strategies. One promising approach is to block the infection at its earliest
Haoyan Yang, Yinuo Ma, Xinkui Lei, Siyu Chai, Sigen Zhang, Guimin Su, Songping Li, Lin Du   +7 more
doaj   +2 more sources

Structural biology of gram‐positive bacterial adhesins [PDF]

Protein Science, 2011
AbstractThe structural biology of Gram‐positive cell surface adhesins is an emerging field of research, whereas Gram‐negative pilus assembly and anchoring have been extensively investigated and are well understood. Gram‐positive surface proteins known as MSCRAMMs (microbial surface components recognizing adhesive matrix molecules) and individual ...
K. Vengadesan, S. Narayana
semanticscholar   +3 more sources