Results 41 to 50 of about 1,156,649 (199)
Catch-bond mechanism of the bacterial adhesin FimH [PDF]
Nature Communications, 2016 AbstractLigand–receptor interactions that are reinforced by mechanical stress, so-called catch-bonds, play a major role in cell–cell adhesion. They critically contribute to widespread urinary tract infections by pathogenic Escherichia coli strains. These pathogens attach to host epithelia via the adhesin FimH, a two-domain protein at the tip of type I ...
Sauer, Maximilian M. +9 more
openaire +6 more sources
CEACAM1 recognition by bacterial pathogens is species-specific
BMC Microbiology, 2010 Background Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), an immunoglobulin (Ig)-related glycoprotein, serves as cellular receptor for a variety of Gram-negative bacterial pathogens associated with the human mucosa.
Kammerer Robert +4 more
doaj +1 more source
The Transmembrane Mucin MUC1 Facilitates β1-Integrin-Mediated Bacterial Invasion
mBio, 2021 Bacteria can exploit membrane receptor integrins for cellular invasion, either by direct binding of bacterial adhesins or utilizing extracellular matrix components.
Xinyue Li +4 more
doaj +1 more source
How bacteria hack the matrix and dodge the bullets of immunity
European Respiratory Review, 2018 Haemophilus influenzae, Moraxella catarrhalis and Pseudomonas aeruginosa are common Gram-negative pathogens associated with an array of pulmonary diseases. All three species have multiple adhesins in their outer membrane, i.e.
Magnus Paulsson, Kristian Riesbeck
doaj +1 more source
Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion
FEBS Open Bio, EarlyView.Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng +2 more
wiley +1 more source
An internal thioester in a pathogen surface protein mediates covalent host binding
eLife, 2015 To cause disease and persist in a host, pathogenic and commensal microbes must adhere to tissues. Colonization and infection depend on specific molecular interactions at the host-microbe interface that involve microbial surface proteins, or adhesins.
Miriam Walden +14 more
doaj +1 more source
Structure and Conservation of Amyloid Spines From the Candida albicans Als5 Adhesin
Frontiers in Molecular Biosciences, 2022 Candida Als family adhesins mediate adhesion to biological and abiotic substrates, as well as fungal cell aggregation, fungal-bacterial co-aggregation and biofilm formation.
Nimrod Golan +4 more
doaj +1 more source
Advanced Functional Materials, EarlyView.Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana +2 more
wiley +1 more source
mBio, 2016 The first step in the infection of humans by microbial pathogens is their adherence to host tissue cells, which is frequently based on the binding of carbohydrate-binding proteins (lectin-like adhesins) to human cell receptors that expose glycans.
Francesco S. Ielasi +6 more
doaj +1 more source
Journal of Biological Chemistry, 2012 Background: Collagen adhesins play critical roles in bacterial colonization. Results: Several structural aspects influence binding affinity, binding ratio, and kinetics of binding to type I collagen.
C. Ross +5 more
semanticscholar +1 more source