Results 101 to 110 of about 137,133 (310)

Adverse cardiac events of hypercholesterolemia are enhanced by sitagliptin in sprague dawley rats

Nutrition & Metabolism
Background Cardiovascular disease (CVD) affects millions worldwide and is the leading cause of death among non-communicable diseases. Western diets typically comprise of meat and dairy products, both of which are rich in cholesterol (Cho) and methionine (
Henry A. Palfrey, Avinash Kumar, Rashmi Pathak, Kirsten P. Stone, Thomas W. Gettys, Subramanyam N. Murthy   +5 more
doaj   +1 more source

MiR-455 targeting SOCS3 improve liver lipid disorders in diabetic mice

Adipocyte, 2020
MiR-455 has been verified a key regulator of brown adipose tissue and adipose tissue-specific overexpression of miR-455 (ap2-miR-455) mice could combat high-fat-diet-induced obesity.
Shu Fang, Jie Feng, Hongbin Zhang, Ping Li, Yudan Zhang, Yanmei Zeng, Yingying Cai, Xiaochun Lin, Yaoming Xue, Meiping Guan   +9 more
doaj   +1 more source

Niche‐Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus Organoids

Advanced Science, EarlyView.
Compared to E8, mTeSR1 culture downregulated WNT and TGF‑β signaling, and upregulated neural differentiation pathways, enhancing neural priming. Under skin organoid induction conditions, mTeSR1‑cultured hESCs generated organoids with significantly higher neuroepithelial differentiation.
Zhongliang Chen, Liangxia Jiang, Xianbin Wang, Lili Zhong, Rongcan Luo, Min Su, Liangzhao Chu, Peng Luo   +7 more
wiley   +1 more source

Weighing in on Adipocyte Precursors [PDF]

, 2014
Obesity, defined as an excessive increase in white adipose tissue (WAT), is a global health epidemic. In obesity, WAT expands by increased adipocyte size (hypertrophy) and number (hyperplasia).
Rodeheffer, Matthew S., Jeffery, Elise, Berry, Ryan   +2 more
core   +1 more source

MiR-130a in the adipogenesis of human SGBS preadipocytes and its susceptibility to androgen regulation

Adipocyte, 2020
Objectives: Adipogenesis is the differentiation process generating mature adipocytes from undifferentiated mesenchymal stem cells. The differentiation can be inhibited by androgens, although knowledge about intracellular effectors of this inhibition is ...
Thomas Greither, Carina Wenzel, Julia Jansen, Matthias Kraus, Martin Wabitsch, Hermann M. Behre   +5 more
doaj   +1 more source

Layer‐Specific Dermal and Subcutaneous Delivery via Modular LNP–Hydrogel‐Integrated Threaded Microneedles

Advanced Science, EarlyView.
Guided by spatial transcriptomics and clinical validation, a threaded microneedle platform enables precise layer‐specific delivery across the dermis and subcutaneous tissue. By addressing distinct pathogenic remodeling in different skin layers, this strategy coordinates compartment‐specific intervention, restores tissue architecture, and offers a ...
Fangzhou Xie, Yixiang Zhang, Shifeng Ling, Yuxuan Huang, Yingying Wei, Rao Fu, Jiahao He, Baikun Liu, Lucia Zhou, Kaifeng Huo, Yida Wang, Qingfeng Li, Yawei Du, Wenguo Cui, Yun Xie   +14 more
wiley   +1 more source

A compendium of adipocyte morphologies across different breast pathologies

Adipocytes are abundant in the breast tissue microenvironment. In breast cancer, they can change morphologically according to their proximity to tumour cells, with the closest becoming cancer-associated adipocytes (CAAs).
Rochford, Justin J., Speirs, Valerie, Elsberger, Beatrix, Ibrahim, Hafeez, Dodson, Abigail, Abu-Eid, Rasha, Lip, Gerald, Spence, Nicola, Husain, Ehab, Palmer, Kerri, Kusserow, Katharina, Hanna, Katie, Abu-Eid, Rasha; id_orcid   +12 more
core   +1 more source

Understanding Adipocyte Differentiation

, 1998
Gregoire, Francine M., Cynthia M. Smas, and Hei Sook Sul. Understanding Adipocyte Differentiation. Physiol. Rev. 78: 783–809, 1998. — The adipocyte plays a critical role in energy balance.
FRANCINE M. GREGOIRE, HEI SOOK SUL, CYNTHIA M. SMAS   +2 more
core   +1 more source

Single‐Nucleus Atlas of Spinal Sarcopenia Patients Reveals Disruption of Quiescent and Regenerative Satellite Cell Niches in Fatty‐Infiltrated Muscle

Advanced Science, EarlyView.
Mechanisms of Fatty Infiltration and Muscle Degeneration. Clinical metadata identified intramuscular fat accumulation as an independent driver of muscle mass decline. Single‐nucleus RNA sequencing of spinal sarcopenia muscle revealed adipogenic reprogramming of fibro‐adipogenic progenitors, satellite‐cell niche disruption, and elevated levels of the ...
Wenkai Wu, Renxian Wang, Dingding Wang, Quanzhong Ren, Ling Wang, Fangfang Duan, Guihe Yang, Ruixuan Yu, Yi Wang, Yingyu Zhang, Zetong Zang, Chuqi Li, Weijia Liu, Wenshuang Zhang, Yi Yuan, Zitong Cheng, Xiaoguang Cheng, Junbo Liang, Yajun Liu   +18 more
wiley   +1 more source

An investigation of the early molecular regulation of adipogenesis in human mesenchymal stem cells. [PDF]

, 2006
Human bone marrow-derived mesenchymal stem cells (hMSCs) can differentiate in vitro into various lineages including adipocytes, osteoblasts, and chondrocytes.
Westwood, Claire, Westwood, C.
core