Results 71 to 80 of about 183,197 (307)

Unraveling Adipose Tissue Dysfunction: Molecular Mechanisms, Novel Biomarkers, and Therapeutic Targets for Liver Fat Deposition

Cells
Adipose tissue (AT), once considered a mere fat storage organ, is now recognized as a dynamic and complex entity crucial for regulating human physiology, including metabolic processes, energy balance, and immune responses.
Marta Lopez-Yus, Carlos Hörndler, Sofia Borlan, Vanesa Bernal-Monterde, Jose M. Arbones-Mainar   +4 more
doaj   +1 more source

Stimulation of glucose utilization in 3T3 adipocytes and rat diaphragm in vitro by the sulphonylureas, glimepiride and glibenclamide, is correlated with modulations of the cAMP regulatory cascade [PDF]

, 1994
The long-term hypoglycemic activity of sulphonylurea drugs has been attributed, in part at least, to the stimulation of glucose utilization in extra-pancreatic tissues. The novel sulphonylurea, glimepiride, gives rise to a longer lasting reduction in the
Altan, Aoki, Avruch, Bak, Begum, Brown, Caren, Clancy, Cooper, Cushman, Daniels, Davidson, Farese, Feldman, Feldman, Gavin, Geisen, Gould, Guinovart, Hirshman, Honnor, Jacobs, Jacobs, Jacobs, James, James, Karnieli, Kirsch, Klip, Kolterman, Kono, Lane, Larner, Lawrence, Lawson, Lebovitz, Leichter, Maloff, Mandarino, Misek, Moody, Müller, Müller, Müller, Müller, Müller, Okuno, Oron, Osegawa, Panten, Popov, Putnam, Reusch, Rogers, Roskoski, Saltiel, Saltiel, Saltiel, Simonson, Smith, Solomon, Standing, Suissa, Suzuki, Tordjman, Towbin, Van Putten, Vila, Villalba, Wang, Wang, Wieland, Wray, Yalow, Zinman, Zuber   +75 more
core   +1 more source

3D Soft Hydrogels Induce Human Mesenchymal Stem Cells “Deep” Quiescence

Advanced Healthcare Materials, EarlyView.
Three‐dimensional soft hydrogels mimicking the bone marrow niche induce deep quiescence in human mesenchymal stem cells. Unlike 2D culture, 3D matrices halt proliferation, regulate cell‐cycle and quiescence markers, and downregulate mTORC1 signaling, preserving stem cell phenotype and therapeutic potential ex vivo.
David Boaventura Gomes, Timo Rademakers, Ana Filipa Henriques Lourenço, Andrea Calore, Clarissa Tomasina, Denis van Beurden, Jinjie Venema, Bryan Chömpff, Hong Liu, Nicole Bouvy, Sandra Camarero‐Espinosa, Lorenzo Moroni   +11 more
wiley   +1 more source

Adipocytes as lipid sensors of oleic acid transport through a functional Caco-2/HT29-MTX intestinal barrier

Adipocyte, 2019
Adipose tissue function in the regulation of lipemia is highly dependent on intestinal absorption of nutrients. Therefore the aim of the present study was the development and validation of an in vitro multiculture model allowing to measure intestinal ...
Emmanuelle Berger, Alain Géloën
doaj   +1 more source

Integrative analyses of biomarkers and pathways for adipose tissue after bariatric surgery

Adipocyte, 2020
We explored potential biomarkers and molecular mechanisms regarding multiple benefits after bariatric surgery. Differentially expressed genes (DEGs) for subcutaneous adipose tissue (AT) after bariatric surgery were identified by analyzing two expression ...
Yingshan Liu, Jing Jin, Yanshan Chen, Chuna Chen, Zhenguo Chen, Lingling Xu   +5 more
doaj   +1 more source

Recapitulating Endochondral Ossification for Bone Repair: From Development to Engineering Strategy

Advanced Healthcare Materials, EarlyView.
This review summarizes the developmental basis of endochondral ossification (ECO) and its applications in bone tissue engineering (BTE). It first outlines the key biological processes and signaling pathways underlying ECO, then discusses biomaterial‐based engineering strategies derived from these principles, and finally highlights future directions for
Yiqi Su, Zihao He, Qianqian Chen, Long Chen, Caiyi Wei, Zijin Zhou, Jianhao Lin, Hui Li, Dan Xing   +8 more
wiley   +1 more source

Ubiquitin ligase RNF20 coordinates sequential adipose thermogenesis with brown and beige fat-specific substrates

Nature Communications
In mammals, brown adipose tissue (BAT) and inguinal white adipose tissue (iWAT) execute sequential thermogenesis to maintain body temperature during cold stimuli.
Yong Geun Jeon, Hahn Nahmgoong, Jiyoung Oh, Dabin Lee, Dong Wook Kim, Jane Eunsoo Kim, Ye Young Kim, Yul Ji, Ji Seul Han, Sung Min Kim, Jee Hyung Sohn, Won Taek Lee, Sun Won Kim, Jeu Park, Jin Young Huh, Kyuri Jo, Je-Yoel Cho, Jiyoung Park, Jae Bum Kim   +18 more
doaj   +1 more source

In vitro transdifferentiation of human adipose tissue-derived stem cells to neural lineage cells - a stage-specific incidence

Adipocyte, 2019
The present Study investigated the intrinsic ability of adipose tissue-derived stem cells (ADSCs) and their neural transdifferentiation in a stage-specific manner.
Subathra Radhakrishnan, Omana Anna Trentz, Mettu Srinivas Reddy, Mohamed Rela, Mahesh Kandasamy, Shanmugaapriya Sellathamby   +5 more
doaj   +1 more source

Adipocyte ADAM17 plays a limited role in metabolic inflammation

Adipocyte, 2020
The role of ADAM17, its substrates, and its natural inhibitor has been well studied in the context of inflammation, including metabolic inflammation, with mixed results.
Joseph C. Lownik, Jared S. Farrar, Janina V. Pearce, Francesco S. Celi, Rebecca K. Martin   +4 more
doaj   +1 more source

Cellular uptake of soy-derived phytoestrogens in vitro and in human whole blood [PDF]

, 2008
Epidemiological studies comparing typical Western and traditional Eastern lifestyles indicate that dietary intake of soyderived phytoestrogens, including genistein, daidzein, and equol, may have significant health protective effects on hormone-dependent ...
Bracke, Marc, De Keukeleire, Denis, Depypere, Herman, Heyerick, Arne, Maubach, Julie   +4 more
core