Results 71 to 80 of about 137,133 (310)

Adipocytes as lipid sensors of oleic acid transport through a functional Caco-2/HT29-MTX intestinal barrier

Adipocyte, 2019
Adipose tissue function in the regulation of lipemia is highly dependent on intestinal absorption of nutrients. Therefore the aim of the present study was the development and validation of an in vitro multiculture model allowing to measure intestinal ...
Emmanuelle Berger, Alain Géloën
doaj   +1 more source

Integrative analyses of biomarkers and pathways for adipose tissue after bariatric surgery

Adipocyte, 2020
We explored potential biomarkers and molecular mechanisms regarding multiple benefits after bariatric surgery. Differentially expressed genes (DEGs) for subcutaneous adipose tissue (AT) after bariatric surgery were identified by analyzing two expression ...
Yingshan Liu, Jing Jin, Yanshan Chen, Chuna Chen, Zhenguo Chen, Lingling Xu   +5 more
doaj   +1 more source

The IRE1‐XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5‐HT Dependent Endogenous Anti‐Autophagy Mechanism

Advanced Science, EarlyView.
A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Pengchao Yang, Binxiang Zhu, Yuzhi He, Yang Tian, Honglei Kang, Shian Hu, Pengju Wang, Yong Xu, Zhuowei Lei, Peijun Qi, Hao Yang, Yang Lin, Yimin Dong, Feng Li, Hanfeng Guan   +14 more
wiley   +1 more source

Ubiquitin ligase RNF20 coordinates sequential adipose thermogenesis with brown and beige fat-specific substrates

Nature Communications
In mammals, brown adipose tissue (BAT) and inguinal white adipose tissue (iWAT) execute sequential thermogenesis to maintain body temperature during cold stimuli.
Yong Geun Jeon, Hahn Nahmgoong, Jiyoung Oh, Dabin Lee, Dong Wook Kim, Jane Eunsoo Kim, Ye Young Kim, Yul Ji, Ji Seul Han, Sung Min Kim, Jee Hyung Sohn, Won Taek Lee, Sun Won Kim, Jeu Park, Jin Young Huh, Kyuri Jo, Je-Yoel Cho, Jiyoung Park, Jae Bum Kim   +18 more
doaj   +1 more source

In vitro transdifferentiation of human adipose tissue-derived stem cells to neural lineage cells - a stage-specific incidence

Adipocyte, 2019
The present Study investigated the intrinsic ability of adipose tissue-derived stem cells (ADSCs) and their neural transdifferentiation in a stage-specific manner.
Subathra Radhakrishnan, Omana Anna Trentz, Mettu Srinivas Reddy, Mohamed Rela, Mahesh Kandasamy, Shanmugaapriya Sellathamby   +5 more
doaj   +1 more source

Adipocyte ADAM17 plays a limited role in metabolic inflammation

Adipocyte, 2020
The role of ADAM17, its substrates, and its natural inhibitor has been well studied in the context of inflammation, including metabolic inflammation, with mixed results.
Joseph C. Lownik, Jared S. Farrar, Janina V. Pearce, Francesco S. Celi, Rebecca K. Martin   +4 more
doaj   +1 more source

Gαi1/3 Are Essential for BMP2‐Induced Osteogenesis by Bridging BMP Receptors to the Gab1 Signaling Complex

Advanced Science, EarlyView.
The Gαi1/3 protein is a crucial connecting protein closely related to the signal transduction process of bone formation‐related cytokines such as BMP2. Gαi1/3 mediates downstream signaling pathways such as Smads and MAPK by binding to adaptor proteins like Gab1, thereby promoting the osteogenic effect of BMSCs.
Huajian Shan, Chaowen Bai, Yifei Zhu, Chenyang Xu, Sonngtao Li, Qize Sun, Chang She, Jinyu Bai, Cong Cao, Yitian Yang, Xiaozhong Zhou   +10 more
wiley   +1 more source

Adipocyte epigenetic alterations and potential therapeutic targets in transgenerationally inherited lean and obese phenotypes following ancestral exposures [PDF]

, 2019
The incidence of obesity has increased dramatically over the past two decades with a prevalence of approximately 40% of the adult population within the United States.
King, Stephanie E., Beck, Daniel, Skinner, Michael K., Nilsson, Eric   +3 more
core   +1 more source

pubCounteR: an R package for interrogating published literature for experimentally-derived gene lists within a user-defined biological context

Frontiers in Bioinformatics
Basic and clinical biomedical research relies heavily on modern large-scale datasets that include genomics, transcriptomics, epigenomics, metabolomics, and proteomics, among other “Omics”. These research tools very often generate lists of candidate genes
Marina Leer, Marina Leer, George A. Soultoukis, George A. Soultoukis, Markus Jähnert, Markus Jähnert, Masoome Oveisi, Masoome Oveisi, Dirk Walther, Tim J. Schulz, Tim J. Schulz, Tim J. Schulz   +11 more
doaj   +1 more source

A MetAP2 inhibitor blocks adipogenesis, yet improves glucose uptake in cells

Adipocyte, 2019
Adipose tissue expansion involves angiogenesis to remodel its capillary network. The enzymemethionine aminopeptidase 2(MetAP2) promotes angiogenesis.MetAP2 inhibitors suppress angiogenesis and have potential anti-obesity effect.
Md Abu Bakkar Siddik, Bhaskar C. Das, Louis Weiss, Nikhil V. Dhurandhar, Vijay Hegde   +4 more
doaj   +1 more source