Results 51 to 60 of about 127,948 (310)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

PKA regulates autophagy through lipolysis during fasting

Molecules and Cells
: Autophagy is a crucial intracellular degradation process that provides energy and supports nutrient deprivation adaptation. However, the mechanisms by which these cells detect lipid scarcity and regulate autophagy are poorly understood.
Yul Ji, Yong Geun Jeon, Won Taek Lee, Ji Seul Han, Kyung Cheul Shin, Jin Young Huh, Jae Bum Kim   +6 more
doaj   +1 more source

Lumican modulates adipocyte function in obesity-associated type 2 diabetes

Adipocyte, 2022
Obesity-associated type 2 diabetes (DM) leads to adipose tissue dysfunction. Lumican is a proteoglycan implicated in obesity, insulin resistance (IR), and adipocyte dysfunction. Using human visceral adipose tissue (VAT) from subjects with and without DM,
Strieder-Barboza, Carmen G. Flesher, Lynn M. Geletka, Tad Eichler, Olukemi Akinleye, Alexander Ky, Anne P. Ehlers, Carey N. Lumeng, Robert W. O’Rourke   +8 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Telmisartan reverses antiretroviral-induced adipocyte toxicity and insulin resistance in vitro [PDF]

, 2018
Background: Antiretroviral therapy in HIV-positive patients leads to insulin resistance which is central to the pathogenesis of various metabolic abnormalities and cardiovascular disease seen in this patient group. We have investigated the dose–response
David J Back, Adaikalakoteswari, A., Owen, A., Sudeep P Pushpakom, Pushpakom, S.P., Sudhesh Kumar, Andrew Owen, Back, D.J, Tripathi, G, McTernan, P., Owen, Andrew, Pirmohamed, M., Philip McTernan, Pushpakom, S. P., Kumar, S., Tripathi, G., Antonysunil Adaikalakoteswari, Back, D. J., Adaikalakoteswari, A, Pushpakom, S.P, Adaikalakoteswari, Antonysunil, Owen, A, Back, David J, Pirmohamed, Munir, Pushpakom, Sudeep P, Gyanendra Tripathi, McTernan, P, Pirmohamed, M, Back, D.J., Tripathi, Gyanendra, Kumar, Sudhesh, Munir Pirmohamed, McTernan, Philip, McTernan, P. G., Back, DJ, Kumar, S, Pushpakom, SP   +36 more
core   +1 more source

H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation

eLife, 2013
Enhancers play a central role in cell-type-specific gene expression and are marked by H3K4me1/2. Active enhancers are further marked by H3K27ac. However, the methyltransferases responsible for H3K4me1/2 on enhancers remain elusive. Furthermore, how these
Ji-Eun Lee, Chaochen Wang, Shiliyang Xu, Young-Wook Cho, Lifeng Wang, Xuesong Feng, Anne Baldridge, Vittorio Sartorelli, Lenan Zhuang, Weiqun Peng, Kai Ge   +10 more
doaj   +1 more source

Differences in fatty acid profiles and desaturation indices of abdominal subcutaneous adipose tissue between pregnant women with and without PCOS

Adipocyte, 2020
The objective was to determine the differences in fatty acid (FA) profiles in subcutaneous adipose tissue (AT) between pregnant women with polycystic ovary syndrome (PCOS) and those without PCOS.
Neda Emami, AliReza Alizadeh, Ashraf Moini, Parichehreh Yaghmaei, Maryam Shahhoseini   +4 more
doaj   +1 more source

CIRCADIAN RHYTHMICITY IN MURINE PRE-ADIPOCYTE AND ADIPOCYTE CELLS

Chronobiology International, 2009
Adipose tissue is central to metabolic homeostasis, signaling in part through the secretion of molecules termed adipokines. Circadian rhythms play an important role in adipose physiology, with plasma adipokine concentration and approximately 20 % of the murine adipose transcriptome undergoing 24 h variation. However, due to the heterogeneity of adipose
Otway, DT, Frost, G, Johnston, JD
openaire   +5 more sources

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

Adipocyte-specific Hnrnpa1 knockout aggravates obesity-induced metabolic dysfunction via upregulating of CCL2 [PDF]

Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) is involved in lipid and glucose metabolism via mRNA processing. However, whether and how HNRNPA1 alters adipocyte function in obesity remain obscure.
Ying Yang (24175), Yuqian Bao (290496), Wenfei Li (1461220), Tingting Hu (233489), Jingjing Sun (543035), Xiaoya Li (2022250), Jian Zhou (28020), Yingying Su (229590), Xuhong Lu (12282998), Yiting Xu (586572), Xiaojing Ma (44943)   +10 more
core   +1 more source