Results 41 to 50 of about 137,133 (310)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Insulin prevents fatty acid induced increase of adipocyte size

Adipocyte, 2022
Metabolic disorders related to obesity are largely dependent on adipose tissue hypertrophy, which involves adipocyte hypertrophy and increased adipogenesis.
Emmanuelle Berger, Alain Géloën
doaj   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

PKA regulates autophagy through lipolysis during fasting

Molecules and Cells
: Autophagy is a crucial intracellular degradation process that provides energy and supports nutrient deprivation adaptation. However, the mechanisms by which these cells detect lipid scarcity and regulate autophagy are poorly understood.
Yul Ji, Yong Geun Jeon, Won Taek Lee, Ji Seul Han, Kyung Cheul Shin, Jin Young Huh, Jae Bum Kim   +6 more
doaj   +1 more source

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

Cellular remodeling of lipedema affected subcutaneous adipose tissue

Frontiers in Cell and Developmental Biology
A progressive disease, lipedema is characterized by bilaterally symmetrical and disproportional accumulation of subcutaneous adipose tissue (SAT) in the extremities, leading to severe pain, inflammation, and mobility issues.
Sabrina Gohlke, Francisco Garcia-Carrizo, Francisco Garcia-Carrizo, Robin Upmeyer, Tim J. Schulz, Tim J. Schulz, Tim J. Schulz   +6 more
doaj   +1 more source

Brd4 binds to active enhancers to control cell identity gene induction in adipogenesis and myogenesis

Nature Communications, 2017
Despite being an important cancer drug target, the role of epigenetic reader Brd4 in cell differentiation and development remains unclear. Here, the authors provide evidence that Brd4 plays an important role in adipogenesis and myogenesis by binding to ...
Ji-Eun Lee, Young-Kwon Park, Sarah Park, Younghoon Jang, Nicholas Waring, Anup Dey, Keiko Ozato, Binbin Lai, Weiqun Peng, Kai Ge   +9 more
doaj   +1 more source

Lumican modulates adipocyte function in obesity-associated type 2 diabetes

Adipocyte, 2022
Obesity-associated type 2 diabetes (DM) leads to adipose tissue dysfunction. Lumican is a proteoglycan implicated in obesity, insulin resistance (IR), and adipocyte dysfunction. Using human visceral adipose tissue (VAT) from subjects with and without DM,
Strieder-Barboza, Carmen G. Flesher, Lynn M. Geletka, Tad Eichler, Olukemi Akinleye, Alexander Ky, Anne P. Ehlers, Carey N. Lumeng, Robert W. O’Rourke   +8 more
doaj   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

Telmisartan reverses antiretroviral-induced adipocyte toxicity and insulin resistance in vitro [PDF]

, 2018
Background: Antiretroviral therapy in HIV-positive patients leads to insulin resistance which is central to the pathogenesis of various metabolic abnormalities and cardiovascular disease seen in this patient group. We have investigated the dose–response
David J Back, Adaikalakoteswari, A., Owen, A., Sudeep P Pushpakom, Pushpakom, S.P., Sudhesh Kumar, Andrew Owen, Back, D.J, Tripathi, G, McTernan, P., Owen, Andrew, Pirmohamed, M., Philip McTernan, Pushpakom, S. P., Kumar, S., Tripathi, G., Antonysunil Adaikalakoteswari, Back, D. J., Adaikalakoteswari, A, Pushpakom, S.P, Adaikalakoteswari, Antonysunil, Owen, A, Back, David J, Pirmohamed, Munir, Pushpakom, Sudeep P, Gyanendra Tripathi, McTernan, P, Pirmohamed, M, Back, D.J., Tripathi, Gyanendra, Kumar, Sudhesh, Munir Pirmohamed, McTernan, Philip, McTernan, P. G., Kumar, S   +34 more
core   +1 more source