Results 41 to 50 of about 127,948 (310)

An siRNA-based method for efficient silencing of gene expression in mature brown adipocytes [PDF]

, 2016
Brown adipose tissue is a promising therapeutic target for opposing obesity, glucose intolerance and insulin resistance. The ability to modulate gene expression in mature brown adipocytes is important to understand brown adipocyte function and delineate ...
Basse, Astrid Linde, Nedergaard, Jan,, Winther, Sally, Petersen, Marie Christine Helby, Isidor, Marie Sophie, Basse, Astrid L., Cannon, Barbara,, Isidor, Marie S., Cannon, Barbara, Nedergaard, Jan, Hansen, Jacob B., Petersen, M. Christine H.   +11 more
core   +2 more sources

Role of adipocyte-derived lipoprotein lipase in adipocyte hypertrophy [PDF]

Nutrition & Metabolism, 2007
A major portion of available fatty acids for adipocyte uptake is derived from lipoprotein lipase (LPL)-mediated hydrolysis of circulating lipoprotein particles. In vivo studies aimed at identifying the precise role of adipocyte-derived LPL in fat storage function of adipose tissue have been unable to provide conclusive evidence due to compensatory ...
Orlando Robert A, Gonzales Amanda M
openaire   +3 more sources

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Chronic unpredictable stress regulates visceral adipocyte‐mediated glucose metabolism and inflammatory circuits in male rats [PDF]

, 2014
Chronic psychological stress is a prominent risk factor involved in the pathogenesis of many complex diseases, including major depression, obesity, and type II diabetes.
Bakirtzi, Kyriaki, Iliopoulos, Dimitrios, Sideri, Aristea, Bradesi, Sylvie, Polytarchou, Christos, Stavrakis, D, Pothoulakis, Charalabos, Karagiannides, I, Iliopoulos, D, Karagiannides, Iordanes, Golovatscka, V, Sideri, A, Bakirtzi, K, Salas, Martha, Golovatscka, Viktoriya, Stavrakis, Dimitris, Pothoulakis, C, Salas, M, Polytarchou, C, Bradesi, S   +19 more
core   +1 more source

Mechanobiology of Adipocytes

Biology
The growing obesity epidemic necessitates increased research on adipocyte and adipose tissue function and disease mechanisms that progress obesity. Historically, adipocytes were viewed simply as storage for excess energy. However, recent studies have demonstrated that adipocytes play a critical role in whole-body homeostasis, are involved in cell ...
Sean P. Blade, Dylan J. Falkowski, Sarah N. Bachand, Steven J. Pagano, LiKang Chin   +4 more
openaire   +3 more sources

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

willov/comprehensive-adipocyte: v22.12 [PDF]

, 2022
The code used to generate the figures in the first version of the submitted ...
William Lövfors
core   +1 more source

Insulin prevents fatty acid induced increase of adipocyte size

Adipocyte, 2022
Metabolic disorders related to obesity are largely dependent on adipose tissue hypertrophy, which involves adipocyte hypertrophy and increased adipogenesis.
Emmanuelle Berger, Alain Géloën
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Brd4 binds to active enhancers to control cell identity gene induction in adipogenesis and myogenesis

Nature Communications, 2017
Despite being an important cancer drug target, the role of epigenetic reader Brd4 in cell differentiation and development remains unclear. Here, the authors provide evidence that Brd4 plays an important role in adipogenesis and myogenesis by binding to ...
Ji-Eun Lee, Young-Kwon Park, Sarah Park, Younghoon Jang, Nicholas Waring, Anup Dey, Keiko Ozato, Binbin Lai, Weiqun Peng, Kai Ge   +9 more
doaj   +1 more source