Results 21 to 30 of about 137,133 (310)
, 2022 Genome-wide association studies identified single nucleotide polymorphisms on chromosome 7 upstream of KLF14 to be associated with metabolic syndrome traits and increased risk for Type 2 Diabetes (T2D).
Qianyi Yang (11961517) +9 more
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RIP140 represses the “Brown-in-White” adipocyte program including a futile cycle of triacyclglycerol breakdown and synthesis [PDF]
, 2014 Receptor-interacting protein 140 (RIP140) is a corepressor of nuclear receptors that is highly expressed in adipose tissues. We investigated the role of RIP140 in conditionally immortal preadipocyte cell lines prepared from white or brown fat depots.
Edward Curry +25 more
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Diet-Induced Adipocyte Browning [PDF]
, 2021 The adipocyte browning process is a phenomenon that consists in the molecular and morphological remodeling of preadipocytes or mature white adipocytes into multilocular beige fat cells expressing thermogenesis-associated genes.
Wiśniewski, Oskar Wojciech +3 more
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Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function
Nature Communications, 2018 The epigenetic mechanisms regulating adipose tissue development are poorly understood. Here the authors show that reduction of H3K36 methylation in preadipocytes, both by H3.3K36M expression and depletion of H3K36 methyltransferase Nsd2, impairs ...
Lenan Zhuang +9 more
doaj +1 more source
European Journal of Cell Biology, 2013 Adipocytes are the main constituent of adipose tissue and are considered to be a corner stone in the homeostatic control of whole body metabolism. Their primary function is to control energy balance by storing triacylglycerol in periods of energy excess and mobilizing it during energy deprivation.
Aus Tariq, Ali +3 more
openaire +2 more sources
New insights into adipocyte-specific leptin gene expression [PDF]
, 2013 The adipocyte-derived hormone leptin is a critical regulator of many physiological functions, ranging from satiety to immunity. Surprisingly, very little is known about the transcriptional pathways that regulate adipocyte-specific expression of leptin ...
Wrann, Christiane, Rosen, Evan
core +1 more source
PPAR Research, 2012 Brown fat expresses two PGC-1α isoforms (PGC-1α and NT-PGC-1α) and both play a central role in the regulation of cellular energy metabolism and adaptive thermogenesis by interacting with a wide range of transcription factors including PPARγ, PPARα, ERRα,
Hee-Jin Jun +2 more
doaj +1 more source
Methods for assessing adipocyte thermogenesis
, 2023 Assessing various methods to observe and measure thermal production in mitochondria of brown adipocyte tissue. For the prevention and treatment of obesity and associated metabolic diseases, scientists are studying and discovering how activation of ...
Ezekiel, Blessing
core
Adipocyte Secretome Increases Radioresistance of Malignant Melanocytes by Improving Cell Survival and Decreasing Oxidative Status [PDF]
, 2017 Radiotherapy is a treatment option for the majority of malignancies. However, because melanoma is known to be radioresistant, the use of ionizing radiation as an adjuvant therapy in cutaneous melanoma patients is ineffective.
Vieira, Mónica +17 more
core +1 more source
Adipocyte, 2012 When Ron Landes approached me last summer with the idea to launch a journal dedicated to adipose tissue research, it resonated immediately; I loved the idea. Thus, it is with great pleasure that we launch Adipocyte, the first international peer-reviewed multi-disciplinary journal to focus exclusively on research covering all aspects of adipose tissue ...
openaire +2 more sources