Results 11 to 20 of about 106,595 (265)
The International Journal of Biochemistry & Cell Biology, 2010 Lipolysis in adipocytes, the hydrolysis of triacylglycerol (TAG) to release fatty acids (FAs) and glycerol for use by other organs, is a unique function of white adipose tissue. Lipolysis in adipocytes occurs at the surface of cytosolic lipid droplets, which have recently gained much attention as dynamic organelles integral to lipid metabolism ...
Maryam, Ahmadian +2 more
openaire +2 more sources
STAT5-Interacting Proteins: A Synopsis of Proteins that Regulate STAT5 Activity
Biology, 2017 Signal Transducers and Activators of Transcription (STATs) are key components of the JAK/STAT pathway. Of the seven STATs, STAT5A and STAT5B are of particular interest for their critical roles in cellular differentiation, adipogenesis, oncogenesis, and ...
Ashley A. Able +2 more
doaj +1 more source
Current Biology, 2014 SummaryIn the United States alone, one-third of adults and nearly one-quarter of children are clinically obese. This growing epidemic is of serious concern as obesity confers a significant risk to developing numerous chronic conditions, including cancer, diabetes, and heart disease. The alarming incidence of obesity and the rising costs of treating the
openaire +2 more sources
Nature Communications, 2023 Adipose tissue invariant natural killer T (iNKT) cells are a crucial cell type for adipose tissue homeostasis in obese animals. However, heterogeneity of adipose iNKT cells and their function in adipocyte turnover are not thoroughly understood.
Sang Mun Han +15 more
doaj +1 more source
Adipocytes Are the Control Tower That Manages Adipose Tissue Immunity by Regulating Lipid Metabolism
Frontiers in Immunology, 2021 Accumulating evidence reveals that adipose tissue is an immunologically active organ that exerts multiple impacts on the regulation of systemic energy metabolism.
Jeu Park +20 more
doaj +1 more source
Cardiovascular Diabetology, 2023 Background The assessment of obesity-related health risks has traditionally relied on the Body Mass Index and waist circumference, but their limitations have propelled the need for a more comprehensive approach. The differentiation between visceral (VIS)
Marta Lopez-Yus +13 more
doaj +1 more source
Oncostatin M Modulation of Lipid Storage
Biology, 2015 Oncostatin M (OSM) is a cytokine belonging to the gp130 family, whose members serve pleiotropic functions. However, several actions of OSM are unique from those of other gp130 cytokines, and these actions may have critical roles in inflammatory ...
Carrie M. Elks, Jacqueline M. Stephens
doaj +1 more source
European Journal of Cell Biology, 2013 Adipocytes are the main constituent of adipose tissue and are considered to be a corner stone in the homeostatic control of whole body metabolism. Their primary function is to control energy balance by storing triacylglycerol in periods of energy excess and mobilizing it during energy deprivation.
Aus Tariq, Ali +3 more
openaire +2 more sources
Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function
Nature Communications, 2018 The epigenetic mechanisms regulating adipose tissue development are poorly understood. Here the authors show that reduction of H3K36 methylation in preadipocytes, both by H3.3K36M expression and depletion of H3K36 methyltransferase Nsd2, impairs ...
Lenan Zhuang +9 more
doaj +1 more source
PPAR Research, 2012 Brown fat expresses two PGC-1α isoforms (PGC-1α and NT-PGC-1α) and both play a central role in the regulation of cellular energy metabolism and adaptive thermogenesis by interacting with a wide range of transcription factors including PPARγ, PPARα, ERRα,
Hee-Jin Jun +2 more
doaj +1 more source