Results 31 to 40 of about 137,133 (310)

High levels of dietary methionine improves sitagliptin-induced hepatotoxicity by attenuating oxidative stress in hypercholesterolemic rats

Nutrition & Metabolism, 2020
Background Both cholesterol (Cho) and methionine (Met, a precursor for homocysteine) are risk factors for fatty liver disease. Since Western diets are rich in Cho and Met, we investigated the hepatic effects of feeding a diet enriched in Met and Cho ...
Avinash Kumar, Rashmi Pathak, Henry A. Palfrey, Kirsten P. Stone, Thomas W. Gettys, Subramanyam N. Murthy   +5 more
doaj   +1 more source

Free lipid and computerized determination of adipocyte size

, 2018
The size distribution of adipocytes in a suspension, after collagenase digestion of adipose tissue, can be determined by computerized image analysis. Free lipid, forming droplets, in such suspensions implicates a bias since droplets present in the images
Jennische, Eva,, Holmäng, Agneta,, Olausson, Daniel,, Edén, Staffan,, Lönn, Malin,, Svensson, Henrik,   +5 more
core   +1 more source

An siRNA-based method for efficient silencing of gene expression in mature brown adipocytes [PDF]

, 2016
Brown adipose tissue is a promising therapeutic target for opposing obesity, glucose intolerance and insulin resistance. The ability to modulate gene expression in mature brown adipocytes is important to understand brown adipocyte function and delineate ...
Basse, Astrid Linde, Nedergaard, Jan,, Winther, Sally, Petersen, Marie Christine Helby, Isidor, Marie Sophie, Basse, Astrid L., Cannon, Barbara,, Isidor, Marie S., Cannon, Barbara, Nedergaard, Jan, Hansen, Jacob B., Petersen, M. Christine H.   +11 more
core   +1 more source

CABLES1 expression is reduced in human subcutaneous adipose tissue in obesity and type 2 diabetes but may not directly impact adipocyte glucose and lipid metabolism

, 2023
Cdk5 and Abl enzyme substrate 1 (CABLES1) is a cell cycle regulator that has previously been identified as a candidate gene for obesity-related phenotypes, but little is known about its role in adipose tissue metabolism.
Eriksson, Jan, Lundqvist, Martin H., Lundqvist, Martin H.,, Kamble, Prasad G., Pereira, Maria J.,, Hetty, Susanne, Pereira, Maria J., Hetty, Susanne,, Kamble, Prasad G.,, Eriksson, Jan,, Vranic, Milica, Vranic, Milica,   +11 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Role of adipocyte-derived lipoprotein lipase in adipocyte hypertrophy [PDF]

Nutrition & Metabolism, 2007
A major portion of available fatty acids for adipocyte uptake is derived from lipoprotein lipase (LPL)-mediated hydrolysis of circulating lipoprotein particles. In vivo studies aimed at identifying the precise role of adipocyte-derived LPL in fat storage function of adipose tissue have been unable to provide conclusive evidence due to compensatory ...
Orlando Robert A, Gonzales Amanda M
openaire   +3 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis [PDF]

, 2012
Peer ...
Welch, A, Robert Judson (279511), Mirela Delibegović, Louise Grant (181930), Grant Louise, Emma K Lees, Judson, R, Andy Welch (181948), Göransson, Olga, Goransson, O, Barbara B Kahn, George D. Mcilroy (181939), Carl Owen (181917), Mcilroy George D., Kendra K. Bence (149032), Olga Göransson, Mody Nimesh, Benjamin G. Neel (162598), Lees, Emma K, Kahn Barbara B., Louise Grant, Nimesh Mody (181963), Bence, Kendra K., Neel Benjamin G., Bence, KK, Grant, L, Owen, C, Mody, Nimesh, Mcilroy, George D, Neel, BG, Owen, Carl, Welch Andy, Olga Göransson (181943), Agouni, Abdelali, Neel, Benjamin G, Abdelali Agouni, Czopek Alicja, Kahn, Barbara B, Neel, Benjamin G., Bence Kendra K., Agouni, A, Lees, Emma K., McIlroy, George, Bence, Kendra K, Abdelali Agouni (181926), Nimesh Mody, Göransson Olga, Lund University., Judson, Robert, Czopek, Alicja, Mody, N, Czopek, A, Kendra K Bence, Mirela Delibegović (181968), Andy Welch, George D Mcilroy, Alicja Czopek (181921), Grant, Louise, Lees, EK, Benjamin G. Neel, Barbara B. Kahn, Delibegovic, Mirela, Barbara B. Kahn (181955), Agouni Abdelali, Kahn, Barbara B., Judson Robert, Göransson, Olga,, Mcilroy, GD, Welch, Andy, Emma K. Lees (181936), Lees Emma K., Robert Judson, Benjamin G Neel, Delibegovic, M, Kendra K. Bence, Delibegović Mirela, Carl Owen, Owen Carl, Mcilroy, George D., Emma K. Lees, Alicja Czopek, Kahn, BB, George D. Mcilroy, Mcilory, GD   +83 more
core   +2 more sources

Adipocyte-Specific ACKR3 Regulates Lipid Levels in Adipose Tissue [PDF]

, 2021
Dysfunctional adipose tissue (AT) may contribute to the pathology of several metabolic diseases through altered lipid metabolism, insulin resistance, and inflammation.
Doering, Yvonne, Bayasgalan, Soyolmaa, Vorst, Emiel P. C. van der, Gencer, Selin, Peters, Linsey J. F., Müller, Madeleine, Yvonne Jansen, Jansen, Yvonne, van der Vorst, Emiel P. C., Weber, Christian, Soyolmaa Bayasgalan, Selin Gencer, Madeleine Müller, Döring, Yvonne, Mueller, Madeleine, Yvonne Döring, Emiel P. C. van der Vorst, Linsey J. F. Peters, Olga Schengel, Schengel, Olga, Christian Weber   +20 more
core   +2 more sources

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source