Results 231 to 240 of about 265,737 (264)

Interplay of Ser273 Phosphorylation and K268 and K293 Acetylation in PPARγ: Implications for PPARγ Activation

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Post‐translational modifications (PTMs) play a critical role in regulating the transcriptional activity of PPARγ, a nuclear receptor central to glucose and lipid homeostasis. Among these, lysine acetylation at K268 and K293 and phosphorylation at S273 are particularly relevant to insulin sensitivity.
Caique Camargo Malospirito, Marieli Mariano Gonçalves Dias, Gabriel Ernesto Jara, Thayná Mendonça Avelino, Giovanna Blazutti Elias, Paulo Sergio Lopes de Oliveira, Ana Carolina Migliorini Figueira   +6 more
wiley   +1 more source

Osteocytes orchestrate browning: emerging signals in bone-fat crosstalk: a systematic review. [PDF]

Front Endocrinol (Lausanne)
Anees H, Jahed V, Sabouri Z, Jamous R, Pennisi CP, Heiss C, El Khassawna T.   +6 more
europepmc   +1 more source

QSP Modeling Shows Pathological Synergism Between Insulin Resistance and Amyloid‐Beta Exposure in Upregulating VCAM1 Expression at the BBB Endothelium

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 561-571, March 2025.
ABSTRACT Type 2 diabetes mellitus (T2DM), characterized by insulin resistance, is closely associated with Alzheimer's disease (AD). Cerebrovascular dysfunction is manifested in both T2DM and AD, and is often considered as a pathological link between the two diseases.
Zengtao Wang, Vaishnavi Veerareddy, Xiaojiao Tang, Kevin J. Thompson, Sunil Krishnan, Krishna R. Kalari, Karunya K. Kandimalla   +6 more
wiley   +1 more source

HIF1α reinforces PPARγ-dependent metabolic rechanneling to support lipid accumulation in adipocytes. [PDF]

Front Mol Med
Zhu C, Wu M, Pham MD, Wang Y, Das AP, Mao Y, Mirtschink P, Yuan T, Krishnan J.   +8 more
europepmc   +1 more source

Curcumin Alleviates the Osteogenesis Inhibition and the Aging Process in BMSCs Induced by Iron Overload Through Activating the NRF2/GPX4 Pathway

Phytotherapy Research, EarlyView.
Under iron overload conditions, curcumin inhibits cellular senescence and promotes osteogenic differentiation by activating the NRF2/GPX4 signaling pathway in bone marrow mesenchymal stem cells (BMSCs), thereby preventing the onset of osteoporosis. ABSTRACT Dysregulated proliferation and differentiation of bone marrow mesenchymal stem cells (BMSCs ...
Jingmin Che, Qing Feng, Zhixia Zhao, Jingying Sun, Weihao Ren, Yangmeng Feng, Cuixiang Xu, Xu‐Hui Li   +7 more
wiley   +1 more source

FGF21 targets pathways which enhance insulin sensitivity in brown adipose but not skeletal muscle in mice.

Endocrinology
Juber MC, King-McAlpin S, Buscaglia P, Sebag JA, Potthoff MJ.   +4 more
europepmc   +1 more source

Fueling or Fighting Cancer? The Thermogenic Paradox of Brown Adipose Tissue. [PDF]

Curr Obes Rep
Guerrero JJG, Encarnacion PC, Wang CH, Del Rosario MAS, Notarte KI, Zhou J, Hsieh YT, Wang WY, Chang CW, Li WC.   +9 more
europepmc   +1 more source

Severity of Hypoxia-Induced Effects on 3T3-L1 Adipocyte Secretory Function Is Attenuated Dose-Dependently by Individual Short-Chain Fatty Acids. [PDF]

Nutrients
Burns JL, Van K, Alzubi A, Cho CE, Monk JM.   +4 more
europepmc   +1 more source

Hypoxia-inducible factor 1αa regulates lipid metabolism to coordinate adipocyte hypertrophy and hyperplasia in grass carp. [PDF]

J Biol Chem
Wei M, Tian Z, Song L, Xue R, Li H, Ji H, Sun J.   +6 more
europepmc   +1 more source