Results 281 to 290 of about 267,086 (349)

When Fat Goes Astray: Your Liver and Pancreas Get Into Trouble

Portal Hypertension &Cirrhosis, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) and intrapancreatic fat deposition (IPFD) are both common manifestations of ectopic fat accumulation. Although they share multiple risk factors, they also show notable differences in pathological features, standardization of diagnosis, and research maturity.
Yuying Chen, Li Ding, Shan Zhao, Weihong Wang, Jing Zhong, Qiang Yan   +5 more
wiley   +1 more source

Insulin-stimulated glucose uptake is impaired in senescent human adipocytes. [PDF]

Front Endocrinol (Lausanne)
Alexandersson I, Palmgren H, Uhrbom M, Oscarsson J, Boucher J.   +4 more
europepmc   +1 more source

Molecular and genomic advances in breast cancer: A comprehensive review of predictive and therapeutic innovations

Precision Medical Sciences, EarlyView.
Breast cancer subtypes, estrogen receptor‐positive (ER+), HER2‐enriched, and TNBC, are defined by genomic and epigenetic signatures. Multi‐omics profiling, immunotherapy, liquid biopsy, and AI‐driven radiogenomics enable precision medicine. Tools like Oncotype DX and PAM50 support personalized care.
Samina Malik, Arif Malik, Shahzad Ahmad, Hassan Mohsin, Shazia Iqbal   +4 more
wiley   +1 more source

TREM2 promotes adipogenesis of PDGFR-α⁺ adipose stem cells but is dispensable for adipose remodeling and metabolic health during diet-induced obesity. [PDF]

Front Endocrinol (Lausanne)
Dobrijevic A, Korosec A, Brunner JS, Matejovicova L, Gemza A, Lakovits K, Lam HS, Agirre-Lizaso A, Schabbauer G, Knapp S, Sharif O.   +10 more
europepmc   +1 more source

Interplay of Ser273 Phosphorylation and K268 and K293 Acetylation in PPARγ: Implications for PPARγ Activation

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Post‐translational modifications (PTMs) play a critical role in regulating the transcriptional activity of PPARγ, a nuclear receptor central to glucose and lipid homeostasis. Among these, lysine acetylation at K268 and K293 and phosphorylation at S273 are particularly relevant to insulin sensitivity.
Caique Camargo Malospirito, Marieli Mariano Gonçalves Dias, Gabriel Ernesto Jara, Thayná Mendonça Avelino, Giovanna Blazutti Elias, Paulo Sergio Lopes de Oliveira, Ana Carolina Migliorini Figueira   +6 more
wiley   +1 more source

Advances in research on thermogenic substances. [PDF]

J Physiol Anthropol
Tao M, Gao Y, Chai X, Peng J, Guo C, Yu L, Yao Z.   +6 more
europepmc   +1 more source

QSP Modeling Shows Pathological Synergism Between Insulin Resistance and Amyloid‐Beta Exposure in Upregulating VCAM1 Expression at the BBB Endothelium

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 561-571, March 2025.
ABSTRACT Type 2 diabetes mellitus (T2DM), characterized by insulin resistance, is closely associated with Alzheimer's disease (AD). Cerebrovascular dysfunction is manifested in both T2DM and AD, and is often considered as a pathological link between the two diseases.
Zengtao Wang, Vaishnavi Veerareddy, Xiaojiao Tang, Kevin J. Thompson, Sunil Krishnan, Krishna R. Kalari, Karunya K. Kandimalla   +6 more
wiley   +1 more source

Aerobic glycolysis drives differentiation of unilocular adipocytes. [PDF]

J Lipid Res
Maestri A, Cai M, Schipper R, Backman J, Vannay A, Olsson A, Ehrenborg E, Nilsson R, Hagberg CE.   +8 more
europepmc   +1 more source

Gastric Lipoma in a 10‐Year‐Old Patient: A Case Report and Literature Review

Pediatric Discovery, EarlyView.
Yiwen Huang, Ting Li, Baisha Huang, Peng Li, Xiaochun Zhu, Wuping Ge, Chengwei Chai   +6 more
wiley   +1 more source