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Mechanotransduction in adipocytes

Journal of Biomechanics, 2012
Obesity is widely recognized as a major public health problem due to its strong association with a number of serious chronic diseases including hyperlipidemia, hypertension, type II diabetes and coronary atherosclerotic heart disease. During the development of obesity, the positive energy balance involves recruitment of new adipocytes from ...
Amit Gefen, Naama Shoham
openaire   +3 more sources

Human White Adipocytes Convert Into “Rainbow” Adipocytes In Vitro

Journal of Cellular Physiology, 2017
White adipocytes are plastic cells able to reversibly transdifferentiate into brown adipocytes and into epithelial glandular cells under physiologic stimuli in vivo. These plastic properties could be used in future for regenerative medicine, but are incompletely explored in their details.
Maurizi G   +17 more
openaire   +6 more sources

The Emergence of Adipocytes

2010
In mammals, the adipose organ is composed of white adipocytes (primary site in energy storage) and of brown adipocytes (specialized in thermogenesis). Adipocytes arise from mesenchymal stem cells (MSCs) by a sequential pathway of differentiation. MSCs develop either from ectoderm or mesoderm and commit into different undifferentiated precursors, which ...
Louis Casteilla, Patrick Laharrague
openaire   +3 more sources

Remodeling on adipocytic physiology of organophosphorus esters in mature adipocytes

Environmental Pollution, 2022
The emerging endocrine disruption chemicals organophosphate esters (OPEs) pose high risk of metabolic disruption. However, limited information is available on physiological disturbance of OPEs on adipose, a major endocrine and metabolic organ. In this study, physiological change was investigated after exposing 3T3-L1fully differentiated adipocytes to ...
Ying Liu   +6 more
openaire   +2 more sources

Adipocytes

2003
There are several preadipocyte cell lines reported, but in this chapter, we will describe mainly the 3T3-L1 cells, which are best characterized and widely used for molecular biological studies. The 3T3-L1 cells were clonally isolated by Green and Kehinde from 3T3-Swiss albino.
S, Gamou, Y, Shimizu, N, Shimizu
openaire   +2 more sources

Adipocyte Mineralocorticoid Receptor

2019
Mineralocorticoid receptor (MR) has been recently identified in adipose tissue, where its excessive activation contributes to several metabolic derangements often observed in obesity and metabolic syndrome. Recent findings support the existence of a bidirectional cross-talk between adipose tissue and adrenal glands, contributing to obesity-related ...
Infante M.   +4 more
openaire   +5 more sources

Pink Adipocytes

Trends in Endocrinology & Metabolism, 2018
Adipocytes are lipid-rich parenchymal cells contained in a very plastic organ, whose composition can undergo striking physiologic changes. In standard conditions the organ contains white and brown adipocytes which play opposite roles: lipid storage to meet metabolic requirements and lipid burning for thermogenesis, respectively.
openaire   +2 more sources

Hormonal Control of Adipocyte Differentiation and Adipocyte Gene Expression

1988
Publisher Summary This chapter presents a summarization of a large number of studies aimed at elucidating the signaling system by which determined cells decide to activate a terminal differentiation program. Using adipogenic cells in culture, it can be documented that the hormonal milieu plays a major role in dictating the decision to trigger ...
Marc Navre   +4 more
openaire   +3 more sources

Complement, adipocytes and the kiney

Nephrology, 1996
Summary: The complement system has traditionally been thought of as a group of circulating proteins predominantly produced in the liver, with functions in both afferent and efferent arms of the immune response, primarily concerned with host defence. In recent years, it has become apparent that many tissues synthesize and secrete complement components ...
Peters, DK, Mathieson, PW
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Adipocyte biology and adipocytokines

Clinics in Laboratory Medicine, 2004
Adipose tissue actively participates in regulation of food intake, energy expenditure, fuel metabolism, and a variety of other physiologic processes through its endocrine, paracrine, and autocrine secretory products (Table 4). Abnormal synthesis of these secretory products may be related to the pathogenesis of insulin resistance and its complications ...
Abhimanyu Garg, Wasim A. Haque
openaire   +3 more sources

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