Results 11 to 20 of about 60,035 (184)

Matrix Stiffness Orchestrates Mesenchymal Stem Cell Lineage Commitment Toward Osteogenesis and Adipogenesis Through the PIEZO1/SP1/STC2 Axis. [PDF]

Adv Sci (Weinh)
Matrix stiffness directs mesenchymal stem cell lineage commitment through PIEZO1‐dependent activation of the SP1/STC2 pathway. Stiff matrices favor osteogenesis and suppress adipogenesis, whereas the loss of PIEZO1 function impairs early bone formation. STC2 retains lineage‐regulatory activity even when PIEZO1 is inactive.
Zhang S, Li S, Chen W, Song Q, Zhao H, Wang P, Zhang Y, Liang W, Zheng S, Wang J, Chen W, Zhu Y, Zhang Y.   +12 more
europepmc   +2 more sources

Efecto del ácido valproico, tricostatin A y resveratrol sobre la diferenciación del adipocito

NOVA, 2009
La obesidad es un factor de riesgo de enfermedades coronarias, de cáncer, de accidentes cerebrovasculares y de diabetes tipo II. El propósito de este trabajo es evaluar la capacidad del ácido valproico, tricostatin A y resveratrol como agentes que ...
Johana Brochero, Diana Vargas, Carolina Romero, Luis Gustavo Celis, Fernando Lizcano   +4 more
doaj   +1 more source

The histone methyltransferase Suv39h regulates 3T3-L1 adipogenesis

Adipocyte, 2020
We discovered a unique expression pattern of two histone methyltransferases Suv39h1 and Suv39h2 during 3T3-L1 adipogenesis, both of which preferentially catalyse the formation of H3K9 dimethylation (H3K9me2) and further H3K9 trimethylation (H3K9me3), a ...
Jia Jing, Fenfen Li, Lin Zha, Xiaosong Yang, Rui Wu, Shirong Wang, Bingzhong Xue, Hang Shi   +7 more
doaj   +1 more source

Novel Insights into Adipogenesis from the Perspective of Transcriptional and RNA N6‐Methyladenosine‐Mediated Post‐Transcriptional Regulation

Advanced Science, 2020
Obesity is a critical risk factor causing the development of metabolic diseases and cancers. Its increasing prevalence worldwide has aroused great concerns of the researchers on adipose development and metabolic function.
Tongxing Song, Yang Yang, Siwen Jiang, Jian Peng   +3 more
doaj   +1 more source

Low steady-state oxidative stress inhibits adipogenesis by altering mitochondrial dynamics and decreasing cellular respiration

Redox Biology, 2020
Adipogenesis is a fundamental process of white adipose tissue function, supporting lipid storage and release, while avoiding its spillover and ectopic accumulation in tissues and organs.
Raquel Fernando, Kristina Wardelmann, Stefanie Deubel, Richard Kehm, Tobias Jung, Marco Mariotti, Aphrodite Vasilaki, Vadim N. Gladyshev, André Kleinridders, Tilman Grune, José Pedro Castro   +10 more
doaj   +1 more source

Serum amyloid A3 deficiency impairs in vitro and in vivo adipocyte differentiation

Adipocyte, 2021
Obesity, caused by an excess adipose tissue, is one of the biggest health-threats of the 21st century. Adipose tissue expansion occurs through two processes: (i) hypertrophy, and (ii) hyperplasia, the formation of new adipocytes, also termed adipogenesis.
Ellen Vercalsteren, Christine Vranckx, Ines Vermeire, Max Gooijen, Roger Lijnen, Ilse Scroyen   +5 more
doaj   +1 more source

SIRT6 Is Essential for Adipocyte Differentiation by Regulating Mitotic Clonal Expansion

Cell Reports, 2017
Preadipocytes initiate differentiation into adipocytes through a cascade of events. Mitotic clonal expansion, as one of the earliest events, is essential for adipogenesis.
Qiang Chen, Wenhui Hao, Cuiying Xiao, Ruihong Wang, Xiaoling Xu, Huiyan Lu, Weiping Chen, Chu-Xia Deng   +7 more
doaj   +1 more source

Mouse Embryonic Fibroblast Adipogenic Potential: A Comprehensive Transcriptome Analysis

Adipocyte, 2021
Our understanding of adipose tissue has progressed from an inert tissue for energy storage to be one of the largest endocrine organs regulating metabolic homoeostasis through its ability to synthesize and release various adipokines that regulate a myriad
Mohamed Al-Sayegh, Hamad Ali, Mohammad H Jamal, Mei ElGindi, Tina Chanyong, Khulood Al-Awadi, Mohamed Abu-Farha   +6 more
doaj   +1 more source

POU2AF1 promotes MSCs adipogenesis by inhibiting HDAC1 expression

Adipocyte, 2021
Excessive production of visceral adipose is a major risk factor of many diseases. Inhibiting the adipogenesis of mesenchymal stem cells (MSCs) will be an efficient way to block adipose production. We illuminated POU class 2 homeobox associating factor 1 (
Yaqing Wang, Luyang Wang, Zhongping Su, Wei Sun, Mi Zhang, Chuanxi Yang, Jingxin Zhou, Li Jiang, Xiangqing Kong   +8 more
doaj   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source