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Obesity, adipogenesis and insulin resistance
Endocrinología y Nutrición (English Edition), 2011Insulin resistance precedes the development of type 2 diabetes mellitus and is also a common denominator in the so-called metabolic syndrome. Although the cause of insulin resistance has not been fully elucidated, it seems clear that lifestyle changes, including little physical exercise and constant access to food, particularly in developed and ...
Manuel, Ros Pérez, Gema, Medina-Gómez
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Adipogenesis: cellular and molecular aspects
Best Practice & Research Clinical Endocrinology & Metabolism, 2005Obesity and lipoatrophy are major risks for insulin resistance, non-insulin-dependent diabetes and cardiovascular disease. In the past three decades, significant advances have been made in delineating the key transcription factors of adipogenesis, as well as extracellular effectors and intracellular signalling pathways that regulate fat cell formation.
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Oxygen-Dependent Regulation of Adipogenesis
2004Publisher Summary This chapter discusses oxygen-dependent regulation of adipogenesis. Because O 2 sensingplays an important role in energy homeostasis and cell differentiation, O 2 tension can also control adipose tissue function by regulating adipogenesis. Hypoxia inhibits the oxidation of fatty acids in mitochondria, resulting in a relative state
Lillian M, Swiersz +2 more
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Insulin resistance and impaired adipogenesis
Trends in Endocrinology & Metabolism, 2015The adipose tissue is crucial in regulating insulin sensitivity and risk for diabetes through its lipid storage capacity and thermogenic and endocrine functions. Subcutaneous adipose tissue (SAT) stores excess lipids through expansion of adipocytes (hypertrophic obesity) and/or recruitment of new precursor cells (hyperplastic obesity).
Birgit, Gustafson +4 more
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