Results 141 to 150 of about 94,652 (323)

Endogenous Trigeminal Neurons Induce Schwann Differentiation of Donor Stem Cells in Dental Pulp Regeneration via Reciprocal Extracellular Vesicles Interplay

Exploration, EarlyView.
Our study demonstrates that the host TG coordinates with heterologously implanted SHED to regenerate functional dental pulp through reciprocal EVs’ interplay. EVs derived from implanted stem cells migrate to the host TG to activate axonal regeneration.
Wanmin Zhao, Wenzhe Wang, Jia Guo, Jiani Liu, Wei Wang, Dihao Tao, Jiayi Dong, Zhonghan Li, Shiyu Liu, Songtao Shi, Tao Chen, Yan Jin, Bei Li   +12 more
wiley   +1 more source

Pivotal contribution of super-enhancer-driven KLF6 expression to the adipogenesis of human adipose-derived stem cells

Inflammation and Regeneration
Background Super-enhancers (SEs), characterized by dense clusters of enhancer elements enriched with transcriptional activator binding sites, are involved in cell differentiation. However, little is known about SE-mediated regulation of adipogenic genes.
Mai-Phuong Nguyen, Kaoru Yamagata, Anh Phuong Nguyen, Tong Zhang, Hidenori Sakai, Uyen Thi Ngo, Yu Shan, Takashi Otsuka, Ngo Thi Dieu Huong, Takafumi Aritomi, Meng Yuan, Shigeaki Kato, Yoshiya Tanaka, Shingo Nakayamada   +13 more
doaj   +1 more source

Neddylation and Its Target Cullin 3 Are Essential for Adipocyte Differentiation

Cells
The ongoing obesity epidemic has raised awareness of the complex physiology of adipose tissue. Abnormal adipocyte differentiation results in the development of systemic metabolic disorders such as insulin resistance and diabetes. The conjugation of NEDD8
Hongyi Zhou, Vijay Patel, Robert Rice, Richard Lee, Ha Won Kim, Neal L. Weintraub, Huabo Su, Weiqin Chen   +7 more
doaj   +1 more source

FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis

Cell Research, 2014
The role of Fat Mass and Obesity-associated protein (FTO) and its substrate N6-methyladenosine (m6A) in mRNA processing and adipogenesis remains largely unknown. We show that FTO expression and m6A levels are inversely correlated during adipogenesis. FTO
Xu Zhao, Ying Yang, Bao-Fa Sun, Yue Shi, Xin Yang, Wen Xiao, Ya-Juan Hao, X. Ping, Yu-Sheng Chen, Wen-Jia Wang, Kang-Xuan Jin, Xing Wang, Chun-Min Huang, Yu Fu, Xiao-Hu Ge, Shu-hui Song, H. Jeong, Hiroyuki Yanagisawa, Y. Niu, G. Jia, Wei Wu, Wei-Min Tong, Akimitsu Okamoto, Chuan He, Jannie M. Rendtlew Danielsen, Xiu-Jie Wang, Yun-Gui Yang   +26 more
semanticscholar   +1 more source

Nutrition and Metabolic Diseases: A Systematic Review of Functional Foods, Medicinal Plants, Phytochemicals, Bioactive Compounds and Nutrients Effective Against Metabolic Diseases

Food Chemistry International, EarlyView.
The study demonstrates how functional foods, medicinal plants, phytochemicals, bioactive compounds and essential nutrients combat metabolic diseases. It highlights their mechanisms, including antioxidant, anti‐inflammatory, insulin‐sensitising, lipid‐regulating, gut microbiota‐modulating and mitochondrial‐enhancing effects, leading to improved ...
Chinaza Godswill Awuchi, Sana Noreen, Sonia Morya   +2 more
wiley   +1 more source

The Application of Duck Embryonic Fibroblasts CCL-141 as a Cell Model for Adipogenesis

Animals
The duck embryo fibroblast cell line CCL-141, which is currently the only commercialized duck cell line, has been underexplored in adipogenesis research.
Dan-Dan Sun, Xiao-Qin Li, Yong-Tong Liu, Meng-Qi Ge, Zhuo-Cheng Hou   +4 more
doaj   +1 more source

Inhibition of ASCT2 is essential in all‐trans retinoic acid‐induced reduction of adipogenesis in 3T3‐L1 cells

FEBS Open Bio, 2015
Vitamin A has preventive effects on obesity. All‐trans retinoic acid (ATRA), the active form of vitamin A, inhibits lipid accumulation in 3T3‐L1 cells in an experimental adipogenesis model.
Katsuhiko Takahashi, Natsumi Uchida, Chisato Kitanaka, Chiaki Sagara, Masahiko Imai, Noriko Takahashi   +5 more
doaj   +1 more source

Adipose tissue regulates insulin sensitivity: role of adipogenesis, de novo lipogenesis and novel lipids

Journal of Internal Medicine, 2016
Obesity, the major cause of the current global epidemic of type 2 diabetes (T2D), induces insulin resistance in peripheral insulin target tissues. Several mechanisms have been identified related to cross‐talk between adipose tissue, skeletal muscle and ...
U. Smith, B. Kahn
semanticscholar   +1 more source

Syncing Health Timing: Exploring the Interplay of Circadian Rhythms, Obesity, and Cardiovascular Diseases

Food Safety and Health, EarlyView.
Circadian rhythm disruption impairs metabolic regulation, appetite control, and vascular function, promoting obesity and cardiovascular diseases. Evidence highlights a bidirectional relationship where metabolic disorders further disturb circadian timing.
Ghizal Fatima, István Dalmadi, Anna Jánosi, Krisztina Takács, Eszter Halmy   +4 more
wiley   +1 more source

Dietary alpha‐ketoglutarate promotes beige adipogenesis and prevents obesity in middle‐aged mice

Aging Cell, 2019
Aging usually involves the progressive development of certain illnesses, including diabetes and obesity. Due to incapacity to form new white adipocytes, adipose expansion in aged mice primarily depends on adipocyte hypertrophy, which induces metabolic ...
Q. Tian, Jun-Xing Zhao, Qiyuan Yang, Bo Wang, J. Deavila, Mei-Jun Zhu, M. Du   +6 more
semanticscholar   +1 more source