Results 131 to 140 of about 94,652 (323)

Cytoskeleton–Membrane Uncoupling in Duchenne Muscular Dystrophy: Implications for Newborn Screening and Early Protection

Cytoskeleton, EarlyView.
ABSTRACT The cytoskeleton of striated muscle integrates force transmission, mechanotransduction, and sarcolemmal stability through coordinated networks of sarcomeres, costameres, and intermediate filaments. Together, these systems establish mechanical continuity between the contractile apparatus, the sarcolemma, and the extracellular matrix.
Houda Cohen, Nora Hosny, Brian R. Thompson, Joseph M. Metzger   +3 more
wiley   +1 more source

Increased Insulin Action, Glucose Metabolism and Muscle Function in Supervillin‐Knockout and Supervillin‐Mutant Mice

Cytoskeleton, EarlyView.
ABSTRACT We here describe mouse models with complementary homozygous Svil mutations. In skeletal muscle, Svil‐Mut mice express the Svil‐encoded N‐terminus fused to the βgal‐neo gene‐trap tag and lack the highly conserved archvillin C‐terminus; Svil‐KO mice lack expression of all known Svil‐encoded proteins; and Svil‐LoxP mice contain loxP sites for ...
Tara C. Smith, Lauren A. Tauer, Randall H. Friedline, Xiaodi Hu, Duy Tran, Yangyi E. Luo, Nacima Hadjout‐Rabi, Elisabeth R. Barton, Jason K. Kim, Elizabeth J. Luna   +9 more
wiley   +1 more source

Nicotinamide mononucleotide promotes osteogenesis and reduces adipogenesis by regulating mesenchymal stromal cells via the SIRT1 pathway in aged bone marrow

Cell Death and Disease, 2019
Mesenchymal stromal cells (MSCs) can differentiate to various cell types including osteoblasts, chondrocytes, and adipocytes. This cellular flexibility contributes to widespread clinical use of MSCs in tissue repair.
Jie Song, Jing Li, Fang-Ji Yang, G. Ning, Limin Zhen, Lina Wu, Yongyuan Zheng, Qi Zhang, Dong-mei Lin, C. Xie, L. Peng   +10 more
semanticscholar   +1 more source

Polypeptide N-acetylgalactosaminyltransferase-15 regulates adipogenesis in human SGBS cells

Scientific Reports
Adipogenesis involves intricate molecular mechanisms regulated by various transcription factors and signaling pathways. In this study, we aimed to identify factors specifically induced during adipogenesis in the human preadipocyte cell line, SGBS, but ...
Asuka Takahashi, Ryo Koike, Shota Watanabe, Kyoko Kuribayashi, Martin Wabitsch, Masahiko Miyamoto, Akihiko Komuro, Mineaki Seki, Masayuki Nashimoto, Akiko Shimizu-Ibuka, Kikuji Yamashita, Takeo Iwata   +11 more
doaj   +1 more source

The Association Between Parental Food Intake and Loss of Control Eating in Children: An Experimental Test Meal Study

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Loss of control (LOC) eating in children is prospectively associated with excessive weight gain and elevated psychopathology. Parental LOC eating and negative mood in children have been linked to child LOC eating; however, objective evidence on parent–child concordance in energy intake and sense of LOC over eating, particularly in ...
Sarah Maria Luise Thorwarth, Ricarda Schmidt, Anja Hilbert   +2 more
wiley   +1 more source

The Circadian Clock Regulates Adipogenesis by a Per3 Crosstalk Pathway to Klf15

Cell Reports, 2017
The generation of new adipocytes from precursor cells (adipogenesis) has implications for systemic metabolism and is a commonly used model for studying the process of cell differentiation in vitro.
Abhishek Aggarwal, Maria José Costa, Belén Rivero-Gutiérrez, Lijuan Ji, Stefanie L. Morgan, Brian J. Feldman   +5 more
doaj   +1 more source

Ciliary Hedgehog signaling restricts injury-induced adipogenesis

Cell, 2017
SUMMARY Injured skeletal muscle regenerates, but with age or in muscular dystrophies, muscle is replaced by fat. Upon injury, muscle-resident fibro/adipogenic progenitors (FAPs) proliferated and gave rise to adipocytes.
Daniel Kopinke, E. Roberson, Jeremy F. Reiter   +2 more
semanticscholar   +1 more source

MicroRNAs in bovine adipogenesis: Genomic context, expression and function

, 2014
Background MicroRNAs (miRNAs) are small non-coding RNAs found to regulate several biological processes including adipogenesis. Understanding adipose tissue regulation is critical for beef cattle as fat is an important determinant of beef quality and ...
Jin, Weiwu, Guan, Leluo, Romao, Josue M., McAllister, Tim, He, Maolong   +4 more
core   +1 more source

TGF‐β effects on adipogenesis of 3T3‐L1 cells differ in 2D and 3D cell culture conditions

FEBS Open Bio
The TGF‐β superfamily plays a pivotal role in the regulation of adipogenesis, but little is known about the potential differential role of the three isoforms of TGF‐β, TGF‐β‐1~3.
Araya Umetsu, Megumi Watanabe, Tatsuya Sato, Megumi Higashide, Nami Nishikiori, Masato Furuhashi, Hiroshi Ohguro   +6 more
doaj   +1 more source

Nuclear MEK1 sequesters PPARγ and bisects MEK1/ERK signaling: a non-canonical pathway of retinoic acid inhibition of adipocyte differentiation.

PLoS ONE, 2014
Uncontrolled adipogenesis and adipocyte proliferation have been connected to human comorbidities. Retinoic acid (RA) is known to inhibit adipocyte differentiation, however the underlying mechanisms have not been adequately understood.
Sandeep Dave, Ravikanth Nanduri, Hedwin Kitdorlang Dkhar, Ella Bhagyaraj, Alka Rao, Pawan Gupta   +5 more
doaj   +1 more source